Vascular Patterns in Immobilized, Denervated, or Devascularized Rabbit Limbs

Investigations of the Vascular Changes following Amputation on Rabbits

“…detected microangiographically in the amputation stump following myoplasty can be caused by immobilization of the amputated extremity (Ferguson &Akahoshi 1960 andOlerud 1961). detected microangiographically in the amputation stump following myoplasty can be caused by immobilization of the amputated extremity (Ferguson &Akahoshi 1960 andOlerud 1961).…”

“…They concluded that both an increased shunting and a reduced muscle pump function caused a decrease in nutritional blood flow in capillaries and minor vessels, and that this brought about a stagnation in the dilated small vessels. Eichelberger et al (1958) found the same muscular changes after immobilization and denervation, while Ferguson & Akahoshi (1960) reported that muscle atrophy secondary to immobilization is different from the atrophy arising after inactivity. Eichelberger et al (1958) found the same muscular changes after immobilization and denervation, while Ferguson & Akahoshi (1960) reported that muscle atrophy secondary to immobilization is different from the atrophy arising after inactivity.…”

The Vascularization in the Amputation Stumps of Rabbits:A Microangiographic Study

“…After amputation there is an immobilization of the amputated leg as well as a muscular inactivity in the amputation stump, After immobilization of the hind legs of rabbits in plaster casts Ferguson & Akahoshi (1960) and Hulth & Olerud (1961) observed a hypervascularization and a dilation of the larger arteries, whereas increased formation of small vessels was seen after muscular inactivity resulting from tenotomy (Ferguson & Akahoshi 1960). In the present work it was found that the hypervascularization after amputation with myoplasty corresponded to the vascular changes occurring after immobilization, whereas amputation without myoplasty evoked vascular changes corresponding to those described after tenotomy.…”

Phenolsulphonphthalein clearance from the knee joint in normal and pathological states.

“…This increased clearance rate was presumably due to the increased local blood flow, as has been shown in other tissues (Ferguson, Vaughan, and Ward, 1957;Schroder and Seyfarth, 1960;Udagawa, 1964). Ferguson and Akahoshi (1960) reported that the changes in vascular pattern noted in the rabbit after immobilization in plaster are dilatation of the main arteries and increased vascularization about the knee and ankle. Thus, the increased rate of blood flow may be related to the state of the vascular bed and the sympathetic nervous system.…”