Vascular Responses to Dopamine and Dobutamine in the Awake Calf During Constant Aortic Flow or Constant Aortic Pressure

As, Greiner; Tm, Skeehan; Dr, Larach; Hg, Schuler; Ws, Pierce

doi:10.1097/00005344-199003000-00008

Cited by 2 publications

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“…Blood pressure is increased by vasopressor drug application and fluid therapy, which are provided to achieve a perfusion pressure and maintain adequate blood flow [ 8 ]. Intravenously administered dopamine elevates mean arterial blood pressure of calves by increasing vascular resistance [ 16 ]. The use of high-dose dexamethasone has been shown to increase survival rate [ 15 ] by reducing oxidative stress and organ damage [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

Altan

Üney

et al. 2017

The Journal of Veterinary Medical Science

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The aim of this research was to compare plasma pharmacokinetics of ceftiofur sodium (CS) in healthy calves, and in calves with experimentally induced endotoxemia. Six calves received CS (2.2 mg/kg, IM) 2 hr after intravenous administration of 0.9% NaCl (Ceft group). After a washout period, the same 6 calves received CS 2 hr after intravenous injection of lipopolysaccharide (LPS+Ceft group). Another group of 6 calves received a combination of drug therapies that included CS 2 hr after administration of 0.9% NaCl (Comb group). A third group of 6 calves received the same combination therapy regimen 2 hr after intravenous injection of lipopolysaccharide (LPS+Comb group). Plasma concentrations of CS and all desfuroylceftiofur-related metabolites were determined using HPLC, and its pharmacokinetic properties were determined based on a two-compartment model. The peak concentration of CS in the LPS+Comb group occurred the earliest, and the clearance rate of CS was the highest in the Comb and LPS+Comb groups (P<0.05). The elimination half-life of CS in the LPS+Ceft group was longer than that in the Ceft and Comb groups (P<0.05). The results of this study indicate that combined therapies and endotoxemic status may alter the plasma pharmacokinetics of CS in calves.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

Altan

Üney

et al. 2017

The Journal of Veterinary Medical Science

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“…Dobutamine is a sympathomimetics and activates β-adrenergic receptors (β 1 and β 2 mediating cardiac and vascular effects, respectively) as an inodilator [ 12 ] and can be used in cases of congestive heart failure to increase cardiac output and positive inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility. Even though the clear beneficial effect of dobutamine the appropriate role of intravenous inodilator therapy in the management of congestive heart failure has long been a subject of controversy and limitation, mainly because of the side effects such as increased heart rate and O 2 consumption via β-receptor activation [ 13 ], and direct vascular effect and baroreflex feed-back regulation [ 14 ]. So, further investigation is definitely necessary to elucidate the exist electrophysiological mechanism underlying the therapeutic effect of dobutamine, which may in turn benefit for the future clinical application and pharmacological convention of dobutamine.…”

Section: Discussionmentioning

confidence: 99%

Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte

et al. 2015

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BackgroundDobutamine is commonly used for clinical management of heart failure and its pharmacological effects have long been investigated as inotropics via β–receptor activation. However, there is no electrophysiological evidence if dobutamine contributes inotropic action due at least partially to the reverse mode of Na+-Ca2+ exchanger (NCX) activation.MethodsAction potential (AP), voltage-gated Na+ (INa), Ca2+ (ICa), and K+ (Ito and IK1) currents were observed using whole-cell patch technique before and after dobutamine in ventricular cardiomyocytes isolated from adult mouse hearts. Another sets of observation were also performed with Kb-r7943 or in the solution without [Ca2+]o.ResultsDobutamine (0.1–1.0 μM) significantly enhanced the AP depolarization with prolongation of AP duration (APD) in a concentration-dependent fashion. The density of INawas also increased concentration-dependently without alternation of voltage-dependent steady-status of activation and inactivation, reactivation as well. Whereas, the activities for ICa, Ito, and IK1 were not changed by dobutamine. Intriguingly, the dobutamine-mediated changes in AP repolarization were abolished by 3 μM Kb-r7943 pretreatment or by simply removing [Ca2+]o without affecting accelerated depolarization. Additionally, the ratio of APD50/APD90 was not significantly altered in the presence of dobutamine, implying that effective refractory period was remain unchanged.ConclusionThis novel finding provides evidence that dobutamine upregulates of voltage-gated Na+ channel function and Na+ influx-induced activation of the reverse mode of NCX, suggesting that dobutamine may not only accelerate ventricular contraction via fast depolarization but also cause Ca2+ influx, which contributes its positive inotropic effect synergistically with β-receptor activation without increasing the arrhythmogenetic risk.

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Vascular Responses to Dopamine and Dobutamine in the Awake Calf During Constant Aortic Flow or Constant Aortic Pressure

Cited by 2 publications

References 0 publications

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte

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