Vascular Risk Factors and Internal Jugular Venous Flow in Transient Global Amnesia: A Study of 165 Japanese Patients

Himeno, Takahiro; Kuriyama, Masaru; Takemaru, Makoto; Kanaya, Yuhei; Shiga, Yuji; Takeshima, Shinichi; Takamatsu, Kazuhiro; Shimoe, Yutaka; Fukushima, Tomoko; Matsubara, Etsuro

doi:10.1016/j.jstrokecerebrovasdis.2017.05.010

Cited by 12 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current study showed a significant age difference between TGA-patients and AIS-patients. The mean age of our TGA population was in line with the mean age of many other reported study populations ( 14 , 20 , 21 , 31 , 33 , 36 ). Furthermore, the age of our AIS-patients was consistent with other large stroke cohorts ( 37 , 38 ) in previous studies.…”

Section: Other Risk Factorssupporting

confidence: 91%

“…The observation of higher blood pressure values in TIApatients compared to TGA-patients has been described before (21,31) but was never assessed systematically in the acute phase of the syndrome in a representative patient cohort. Several studies investigated the association with chronic hypertension (16,21,31). In contrast, in our study we analyzed blood pressure values in the initial phase after symptom onset.…”

Section: Hypertension and Cerebral Microangiopathymentioning

confidence: 99%

See 1 more Smart Citation

Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension

et al. 2021

View full text Add to dashboard Cite

Objective: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of <24 h. Several studies showed differences in vascular risk factors between TGA compared to transient ischemic attack (TIA) or healthy controls with varying results. This retrospective and cross-sectional study compares the cardiovascular risk profile of TGA patients with that of acute stroke patients.Methods: Cardiovascular risk profile and MR imaging of 277 TGA patients was retrospectively analyzed and compared to 216 acute ischemic stroke patients (26% TIA).Results: TGA patients were significantly younger and predominantly female compared to stroke patients. A total of 90.6% of TGA patients underwent MRI, and 53% of those showed hippocampal diffusion-weighted imaging (DWI) lesions. Scores for cerebral microangiopathy were lower in TGA patients compared to stroke patients. After statistical correction for age, TGA patients had higher systolic and diastolic blood pressure, higher cholesterol levels, lower HbA1c, as well as blood glucose levels, and lower CHA2DS2-VASc scores. Stroke patients initially displayed higher CRP levels than TIA and TGA patients. TGA patients without DWI lesions were older and showed higher CHA2DS2-VASc scores compared to TGA patients with DWI lesions.Conclusion: This study revealed significant differences between TGA and stroke patients in regard to the cardiovascular risk profile. Our main findings show a strong association between acute hypertensive peaks and TGA in patients not adapted to chronic hypertension, indicating a vascular cause of the disease.

show abstract

Section: Other Risk Factorssupporting

confidence: 91%

Section: Hypertension and Cerebral Microangiopathymentioning

confidence: 99%

Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension

et al. 2021

View full text Add to dashboard Cite

show abstract

“… 7 In addition, the higher prevalence of conventional risk factors (DM, hypertension and A-Fib) can be attributed to the development of IS in TGA, although patients with TGA showed a lower prevalence of vascular risk factors than patients with TIA and lacunar cerebral infarction. 29 However, this paradigm shift could potentially bias the TGA diagnosis since it is based on clinical criteria, not on concomitant cardiovascular risk factors. Rather, our conclusion might better be applied to patients with TGA with several risk factors who are already taking antithrombotics (81%) despite our results being extracted from real-world data.…”

Section: Discussionmentioning

confidence: 99%

Risk of ischaemic stroke in patients with transient global amnesia: a propensity-matched cohort study

et al. 2021

View full text Add to dashboard Cite

BackgroundThe exact pathophysiological mechanism of transient global amnesia (TGA) is unknown. It is debatable whether TGA is a risk factor for stroke. Therefore, here we investigated the possibility of TGA as a risk factor for stroke in a real-world setting using large-scale nationwide health claims data.MethodsWe used health claims data from the Korean National Health Insurance Service (NHIS). Patients diagnosed with TGA between 2007 and 2013 were selected. We initially extracted patients without TGA who were preferentially matched for age and sex with the patients with TGA at a ratio of 10:1 from the whole dataset. Further, we performed 1:2 propensity score matching analysis to balance the baseline characteristics between the two groups. In the propensity score-matched dataset, we performed multivariable Cox regression analysis to investigate the association between TGA and stroke type, including ischaemic, haemorrhagic and all stroke types.ResultsPatients with TGA (n=14 673) were selected from the NHIS database. After extracting from the whole database (n=140 486) and propensity score matching their data at a 1:2 ratio, a total of 10 448 and 20 442 patients were finally assigned to the TGA and control groups, respectively. The multivariable Cox regression analysis demonstrated that the TGA group had a higher risk of ischaemic stroke and all types of stroke (adjusted HR=1.194; 95% CI: 1.043 to 1.368; and HR=1.197; 95% CI: 1.056 to 1.357, respectively).ConclusionsAnalysis of the nationwide claims database showed that TGA could be an important risk factor for stroke, especially for ischaemic stroke.

show abstract

“…In previous studies, dyslipidemia was described either more frequently in stroke patients than TGA patients [ 18 , 41 , 42 , 43 ] or there were no differences between the groups [ 44 , 45 , 46 , 47 , 48 ]. In contrast, our study disclosed higher serum cholesterol levels on admission in TGA patients as compared to acute stroke patients [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Transient Global Amnesia (TGA): Sex-Specific Differences in Blood Pressure and Cerebral Microangiopathy in Patients with TGA

Rogalewski

Beyer

Friedrich

et al. 2022

JCM

View full text Add to dashboard Cite

Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear aetiology for a period of less than 24 h. Observed psychological, neuroanatomical and hormonal differences between the sexes in episodic memory suggest sex-specific differences in memory disorders such as TGA. The aim of this study was to determine sex-specific differences in cardiovascular risk profiles, recurrences and magnetic resonance imaging (MRI). In total, 372 hospitalised TGA patients between 01/2011 and 10/2021 were retrospectively analysed. Comparisons were made between female and male TGA patients and compared to 216 patients with acute stroke. In our sample, women were overrepresented (61.8%), especially compared to the general population in the 65–74 age category (χ2 = 10.6, p < 0.02). On admission, female TGA patients had significantly higher systolic blood pressure values and a higher degree of cerebral microangiopathy compared to male TGA patients, whereas acute stroke patients did not. No sex-specific differences were observed with respect to recurrences or hippocampal DWI lesions. Our data demonstrate sex-specific differences in TGA. The higher blood pressure on admission and different degree of cerebral microangiopathy in female TGA patients supports the theory of blood pressure dysregulation as a disease trigger. Distinct precipitating events in female and male patients could lead to differences in the severity and duration of blood pressure abnormalities, possibly explaining the higher incidence in female patients.

show abstract

Vascular Risk Factors and Internal Jugular Venous Flow in Transient Global Amnesia: A Study of 165 Japanese Patients

Cited by 12 publications

References 35 publications

Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension

Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension

Risk of ischaemic stroke in patients with transient global amnesia: a propensity-matched cohort study

Transient Global Amnesia (TGA): Sex-Specific Differences in Blood Pressure and Cerebral Microangiopathy in Patients with TGA

Contact Info

Product

Resources

About