Vascular risk factors in South Asians

Τζιόμαλος, Κωνσταντίνος; Weerasinghe, Charitha; Mikhailidis, Dimitri P.; Seifalian, Alexander M.

doi:10.1016/j.ijcard.2007.11.059

Cited by 48 publications

(41 citation statements)

References 218 publications

(314 reference statements)

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“…Previous studies have observed higher fasting TAG concentrations in South Asians than in White people (1,28) but to our knowledge the present study is the first to report a difference in postprandial TAG concentrations between these two ethnic groups. We are aware of only one other study which has compared postprandial lipemia in South Asians and Europeans and this study did not observe a difference in the lipemic response to high fat meals although postprandial glucose and insulin concentrations were elevated in South Asians (3).…”

Section: Paragraph Number 23contrasting

confidence: 73%

“…These differences suggest a degree of insulin resistance in the South Asian participants and this is consistent with the findings of Cruz and colleagues (3). Insulin resistance is thought to be a major contributor to the increased risk of type 2 diabetes and CHD experienced by those of South Asian descent (23,28). Insulin resistance may also underlie the development of 'early metabolic syndrome' which has been noted in the South Asian pediatric population (7).…”

Section: Paragraph Number 25mentioning

confidence: 99%

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Exercise and Coronary Heart Disease Risk Markers in South Asian and European Men

Arjunan

Bishop

Oliveira

et al. 2013

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Paragraph Number 23contrasting

confidence: 73%

Section: Paragraph Number 25mentioning

confidence: 99%

Exercise and Coronary Heart Disease Risk Markers in South Asian and European Men

Arjunan

Bishop

Oliveira

et al. 2013

Medicine &Amp; Science in Sports &Amp; Exercise

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“…An association between elevated hsCRP levels and increased cardiovascular risk has been reported in European populations (1,3). Although both cFLC and hsCRP are elevated in south Asians with type 2 diabetes (8,9), in this study, we found that cFLC was a better predictor of CVD risk than hsCRP. Healthy south Asians have higher hsCRP levels than white Europeans (9), so the lack of association observed in our study may simply reflect disease-specific and ethnic variations and support the need for more ethnic-specific studies.…”

Section: Discussioncontrasting

confidence: 56%

Elevated Serum Free Light Chains Predict Cardiovascular Events in Type 2 Diabetes

Bellary

Faint²,

Assi³

et al. 2014

Diabetes Care

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OBJECTIVEElevated polyclonal serum immunoglobulin free light chains (FLCs; combined FLCk+FLCl [cFLC]) are associated with adverse clinical outcomes and increased mortality; we investigated cFLC and cardiovascular disease (CVD) events in type 2 diabetes. RESEARCH DESIGN AND METHODSIn a cohort study of 352 south Asian patients with type 2 diabetes, serum cFLC, high-sensitivity C-reactive protein (hsCRP), and standard biochemistry were measured. CVD events over 2 years were recorded and assessed using multiple logistic regression. RESULTScFLC levels were elevated significantly in 29 of 352 (8%) patients with CVD events during 2 years of follow-up (50.7 vs. 42.8 mg/L; P = 0.004). In multivariate analysis, elevated cFLC (>57.2 mg/L) was associated with CVD outcomes (odds ratio 3.3 [95% CI 1.3-8.2]; P = 0.012) and remained significant after adjusting for age, albumin-to-creatinine ratio, diabetes duration, or treatment.CONCLUSIONS cFLC elevation is a novel marker for CVD outcomes in type 2 diabetes that warrants further investigation.Predicting risk of cardiovascular disease (CVD) in type 2 diabetes (1-3) using algorithms achieves only moderate performance particularly in different ethnic populations (3). An association between increased polyclonal combined immunoglobulin free light chain (cFLC, summated FLCk+FLCl) concentrations and increased allcause mortality has been reported (4,5); we assessed the potential of cFLC as a marker of CVD outcomes in south Asian patients with type 2 diabetes. RESEARCH DESIGN AND METHODSThe United Kingdom Asian Diabetes Study was a cluster-randomized controlled trial aimed at reducing cardiovascular risk in south Asian patients with type 2 diabetes (6-8). The current study included 352 south Asian patients whose baseline fasting serum samples were available. Detailed clinical history including treatment, CVD history at baseline and over 2 years of follow-up, plus serum biochemistry at baseline (HbA 1c , lipids, and albumin-to-creatinine ratio [ACR]) were obtained. Serum cFLC (Freelite; The Binding Site Group Ltd, Birmingham, U.K.) and hsCRP (Siemens, München, Germany) levels were measured.

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“…Moreover, the disease occurs on average 5-10 years earlier (7,13,14,41). Among South Asians, insulin resistance probably has more bearing on the development of diabetes than loss of beta-cell function (15).…”

Section: Prevalencementioning

confidence: 99%

Cardiovascular disease and diabetes in patients with African or Asian background

Aambø¹,

Klemsdal²

2017

Tidsskriftet

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Vascular risk factors in South Asians

Cited by 48 publications

References 218 publications

Exercise and Coronary Heart Disease Risk Markers in South Asian and European Men

Exercise and Coronary Heart Disease Risk Markers in South Asian and European Men

Elevated Serum Free Light Chains Predict Cardiovascular Events in Type 2 Diabetes

Cardiovascular disease and diabetes in patients with African or Asian background

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