Vascular Risk Factors of Hippocampal Subfield Volumes in Persons without Dementia: The Medea 7T Study

Blom, Kim; Koek, Huiberdina L.; Zwartbol, Maarten H.T.; Ghaznawi, Rashid; Kuijf, Hugo J.; Witkamp, Theo D.; Hendrikse, Jeroen; Biessels, Geert Jan; Geerlings, Mirjam I.

doi:10.3233/jad-200159

Cited by 7 publications

(10 citation statements)

References 51 publications

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“…Third, psychotropic med-ications prescribed throughout the disease course may have affected clinical and neuroimaging findings of this study. Finally, we did not confirm the smoking history, although it has been reported to be associated with hippocampal subfield volumes in healthy individuals [62]. Our exploratory study should be replicated in further research to overcome these limitations.…”

Section: Discussioncontrasting

confidence: 64%

Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders

et al. 2022

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Introduction: The hippocampus is relevant to cognitive function in schizophrenia (SCZ) and mood disorder patients. Although not anatomically uniform, it is clearly divided into subfields. This study aimed to elucidate the relationship between hippocampal subfield volume and cognitive function in patients with SCZ, bipolar disorder (BP), and major depressive disorder (MDD). Methods: The study included 21 patients with SCZ, 22 with BP, and 21 with MDD and 25 healthy controls (HCs). Neurocognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia. We obtained hippocampal subfield volumes using FreeSurfer 6.0. We compared the volumes of the hippocampal subfield between the 4 groups and ascertained correlation between the cognitive composite score and hippocampal subfield volume in each group. Results: The SCZ group had significantly lower cognitive composite score than the BP, MDD, and HC groups. In the SCZ group, the left and right hippocampus-amygdala transition area and right subiculum and right presubiculum volumes were significantly reduced compared to those in the HC group. The left presubiculum volumes in the SCZ group were significantly reduced compared to those in the MDD group. Subfield volumes did not significantly differ between the BP, MDD, and HC groups. Interestingly, in the SCZ group, volumes of the right CA1, right molecular layer of the hippocampus, and right granule cell and molecular layer of the dentate gyrus were significantly correlated with the cognitive composite score. Conclusion: Patients with SCZ had poorer cognitive function, which is related to their hippocampal pathology, than those with mood disorders.

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Section: Discussioncontrasting

confidence: 64%

Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders

et al. 2022

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“…We performed multiple imputation with 20 datasets to address missing values of studied risk factors, imaging markers of cerebrovascular disease, and cognitive functioning. Data were analyzed by pooling the 20 Modified Poisson regression with robust error variance was used to estimate relative risks (RR) for presence of CMIs, with vascular risk factors and MRI markers of cerebrovascular disease as independent variables, adjusted for age and sex (model 1) and additionally for educational level, history of stroke or TIA, BMI, smoking status, alcohol intake, hypertension, diabetes, and hypercholesterolemia (model 2). We used modified Poisson regression because it has similar flexibility and robustness as log-binomial regression but does not suffer from convergence errors.…”

Section: Discussionmentioning

confidence: 99%

“…A detailed description of the recruitment settings is published elsewhere. 20 1) Recruited general practice patients were !60 years; had no clinical diagnosis of mild cognitive impairment (MCI), dementia or other neurological conditions affecting cognition; had no terminal illness; had no previous medical evaluations for cognitive complaints; and had a Clinical Dementia Rating Scale (CDR) 0. 2) The PREDICT-MR study originated from a multicenter prospective cohort investigating major depressive disorder in adult primary care patients.…”

Section: Study Populationmentioning

confidence: 99%

Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning – The Medea-7T study

Zwartbol

Rissanen

Ghaznawi

et al. 2021

J Cereb Blood Flow Metab

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We determined the occurrence and association of cortical cerebral microinfarcts (CMIs) at 7 T MRI with risk factors, neuroimaging markers of small and large vessel disease, and cognitive functioning. Within the Medea-7T study, a diverse cohort of older persons with normal cognition, patients with vascular disease, and memory clinic patients, we included 386 participants (68 ± 9 years) with available 7 T and 1.5 T/3T brain MRI, and risk factor and neuropsychological data. CMIs were found in 10% of participants and were associated with older age (RR = 1.79 per +10 years, 95%CI 1.28–2.50), history of stroke or TIA (RR = 4.03, 95%CI 2.18–7.43), cortical infarcts (RR = 5.28, 95%CI 2.91–9.55), lacunes (RR = 5.66, 95%CI 2.85–11.27), cerebellar infarcts (RR = 2.73, 95%CI 1.27–5.84) and decreased cerebral blood flow (RR = 1.35 per −100 ml/min, 95%CI 1.00–1.83), after adjustment for age and sex. Furthermore, participants with >2 CMIs had 0.5 SD (95%CI 0.05–0.91) lower global cognitive performance, compared to participants without CMIs. Our results indicate that CMIs on 7 T MRI are observed in vascular and memory clinic patients with similar frequency, and are associated with older age, history of stroke or TIA, other brain infarcts, and poorer global cognitive functioning.

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“…The combination of high-resolution 7T imaging and automatic subfield segmentation of the hippocampus has been applied to investigate AD (83), temporal lobe epilepsy (84,85), major depressive disorder (MDD) (86), and vascular risk factors (87). However, caution is required when using MP2RAGE imaging because its T1 reproducibility and volumetry at 7T is affected by B1+ inhomogeneity (88,89).…”

Section: The Hippocampusmentioning

confidence: 99%

Neuroimaging at 7 Tesla: a pictorial narrative review

Okada¹,

Fujimoto²,

Fushimi³

et al. 2022

Quant Imaging Med Surg

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Neuroimaging using the 7-Tesla (7T) human magnetic resonance (MR) system is rapidly gaining popularity after being approved for clinical use in the European Union and the USA. This trend is the same for functional MR imaging (MRI). The primary advantages of 7T over lower magnetic fields are its higher signal-to-noise and contrast-to-noise ratios, which provide high-resolution acquisitions and better contrast, making it easier to detect lesions and structural changes in brain disorders. Another advantage is the capability to measure a greater number of neurochemicals by virtue of the increased spectral resolution.Many structural and functional studies using 7T have been conducted to visualize details in the white matter and layers of the cortex and hippocampus, the subnucleus or regions of the putamen, the globus pallidus, thalamus and substantia nigra, and in small structures, such as the subthalamic nucleus, habenula, perforating arteries, and the perivascular space, that are difficult to observe at lower magnetic field strengths. The target disorders for 7T neuroimaging range from tumoral diseases to vascular, neurodegenerative, and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, major depressive disorder, and schizophrenia. MR spectroscopy has also been used for research because of its increased chemical shift that separates overlapping peaks and resolves neurochemicals more effectively at 7T than a lower magnetic field. This paper presents a narrative review of these topics and an illustrative presentation of images obtained at 7T. We expect 7T neuroimaging to provide a new imaging biomarker of various brain disorders.

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Vascular Risk Factors of Hippocampal Subfield Volumes in Persons without Dementia: The Medea 7T Study

Cited by 7 publications

References 51 publications

Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders

Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders

Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning – The Medea-7T study

Neuroimaging at 7 Tesla: a pictorial narrative review

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