“…In experimental animals in vivo, it is emphasized that hyperthermia may improve blood supply and therefore influence bone metabolism. (3,17) However, when heat is applied locally to a specific site such as an articular joint, (2) a direct effect on the bone-forming cells, that is, the osteoblasts, is likely. Therefore, the aim of this work was to investigate the direct effects of temperature on the proliferation and differentiation of human bone marrow-derived stromal cells (BMSCs) and the osteoblastlike MG-63 cells in culture conditions.…”