Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity

Lin, Yan‐Hui; Chiba, Shunmei; Suzuki, Akira; Yamaguchi, Satoshi; Nakanishi, Takaya; Matsumoto, Hirofumi; Ikeda, Yoshihiko; Ishibashi‐Ueda, Hatsue; Hirano, Ken‐ichi; Kato, Seiya

doi:10.1016/j.bbrc.2013.03.109

Cited by 12 publications

(12 citation statements)

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“…Furthermore, we have reported that tumor necrosis factor‐α‐induced adhesion molecule expression was enhanced via activation of nuclear factor‐κB in ECs with defective intracellular TG hydrolysis in vitro . More recently, we have reported that TG‐deposit SMCs have a pro‐inflammatory phenotype in vitro . It would be important to know the extent to which such TG‐deposit vascular cells might contribute to the formation of diffuse, narrow atherosclerotic lesions and the pathogenesis of diabetic coronary artery disease …”

Section: Discussionmentioning

confidence: 99%

“…26 More recently, we have reported that TG-deposit SMCs have a proinflammatory phenotype in vitro. 27 It would be important to know the extent to which such TG-deposit vascular cells might contribute to the formation of diffuse, narrow atherosclerotic lesions and the pathogenesis of diabetic coronary artery disease. 8,28 The pathophysiological significance of tissue TG accumulation in the heart can be speculated as follows.…”

Section: Discussionmentioning

confidence: 99%

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Coronary triglyceride deposition in contemporary advanced diabetics

Ikeda

Zaima

Hirano

et al. 2014

Pathology International

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It is of importance to clarify pathophysiology of diabetic heart diseases such as heart failure and coronary artery disease. We reported a novel clinical phenotype called triglyceride deposit cardiomyovasculopathy (TGCV), showing aberrant TG accumulation in both coronary arteries and myocardium, in a cardiac transplant recipient. Here, we examined autopsied diabetics for TG deposition in cardiovasculature. Consecutive series of hearts from advanced diabetes mellitus (DM) subjects (DM group: DMG, n = 20) and those from age-and sex-matched non-diabetic controls (non DM group: NDMG, n = 20) were examined. The diagnostic criteria of 'advanced DM' was made based on 2014 Clinical Practice Recommendations proposed by the American Diabetes Association. The mean duration of DM was 15.8 years. All DMG suffered from heart diseases including coronary artery diseases and 14 subjects had multi-vessel disease. Tissue TG contents were measured biochemically. Coronary arterial TG contents was significantly higher in DMG compared with NDMG. Spatial distribution of TG in transverse sections of coronary arteries showed TG deposition mainly in smooth muscle cells by Imaging Mass Spectrometry. Abundant TG deposition in coronary artery might be associated with advanced DM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Coronary triglyceride deposition in contemporary advanced diabetics

Ikeda

Zaima

Hirano

et al. 2014

Pathology International

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“…In addition, it has no direct relationship with Annals of Nuclear Cardiology J-STAGE Advance published date: August 23, 2017 doi: 10.17996/anc. [17][18][19][20][21][22][23][24][25][26][27][28] plasma TG levels, because regulatory mechanism and responsible enzymes are different intracellularly from those in plasma (7). The probands for TGCV carried genetic mutations in the adipose triglyceride lipase (ATGL), which is the ratelimiting enzyme for hydrolysis of intracellular TG (8).…”

Section: T Riglyceride Deposit Cardiomyovasculopathy (Tgcv) Is Amentioning

confidence: 99%

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Higashi

Ikeda

Miyauchi

et al. 2017

Annals of Nuclear Cardiology

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Triglyceride deposit cardiomyovasculopathy (TGCV) is a novel clinical entity we found in patients withThese results suggest that TGCV might be difficult to diagnose in daily clinics, however be more prevalent than expected, and a possible important cause of cardiac death. This review article focuses on imaging modalities to evaluate cardiomyovascular TG accumulation of this novel disease. Data and images are shown from pathological analyses, imaging mass spectrometry, myocardial scintigraphy with a radioactive analogue for LCFA, iodine-123-β-methyl iodophenyl-pentadecanoic acid, MR spectroscopy, and CT-based TG imagings in primary TGCV patients with genetic ATGL deficiency, which is ultra-rare, but the monogenic model.

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“…The distinct phenotype of ATGL-KO and its deviated gene expressions are corrected by an ectopic transfer of the wild-type Atgl gene. The regulatory mechanism of the ATGL-KO SMC phenotype is still unclear [ 132 ]. In vitro ATGL knockdown in the HAEC endothelial cell line, stimulated with TNFα, up-regulates the expression of the adhesion molecule, intracellular adhesion molecule (ICAM-1), resulting in enhanced monocyte adhesion [ 133 ].…”

Section: Fatty Acid Signaling In Different Tissuesmentioning

confidence: 99%

Fatty Acid Signaling: The New Function of Intracellular Lipases

Papáčková

Cahová

2015

IJMS

115

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Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid droplets have been considered to be only passive “energy conserves”. Nevertheless, degradation of TAG gives rise to a pleiotropic spectrum of bioactive intermediates, which may function as potent co-factors of transcription factors or enzymes and contribute to the regulation of numerous cellular processes. From this point of view, the process of lipolysis not only provides energy-rich equivalents but also acquires a new regulatory function. In this review, we will concentrate on the role that fatty acids liberated from intracellular TAG stores play as signaling molecules. The first part provides an overview of the transcription factors, which are regulated by fatty acids derived from intracellular stores. The second part is devoted to the role of fatty acid signaling in different organs/tissues. The specific contribution of free fatty acids released by particular lipases, hormone-sensitive lipase, adipose triacylglycerol lipase and lysosomal lipase will also be discussed.

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Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity

Cited by 12 publications

References 29 publications

Coronary triglyceride deposition in contemporary advanced diabetics

Coronary triglyceride deposition in contemporary advanced diabetics

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Fatty Acid Signaling: The New Function of Intracellular Lipases

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