2009
DOI: 10.1182/blood-2007-05-090944
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Vascular smooth muscle–derived tissue factor is critical for arterial thrombosis after ferric chloride–induced injury

Abstract: Tissue factor (TF) initiates coagulation, regulates hemostasis, and plays a critical role in mediating arterial thrombosis. TF is up-regulated in vascular smooth muscle cells (VSMCs) in atherosclerosis and arterial injury. To examine the biologic role of VSMC-derived TF, we crossed TF flox/flox mice with SM22␣Cre ؉/؊ mice. TF mRNA and activity were decreased in the aortic media of TF-deficient mice by 96% and 94.8%, respectively. There were no differences in TF activity measured in plasma or concentrated micro… Show more

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Cited by 99 publications
(88 citation statements)
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“…34 Although the relative contributions of arterial wall-bound versus circulating TF to thrombosis remain to be determined, it is clear that TF plays a critical role in mediating arterial thrombosis. 21,35,36 Intriguingly, celecoxib treatment has been shown to increase TF expression in heart and lung and to increase plasma TF activity, 14 suggesting that decreased prostanoid levels may result in TF upregulation.…”
Section: Discussionmentioning
confidence: 99%
“…34 Although the relative contributions of arterial wall-bound versus circulating TF to thrombosis remain to be determined, it is clear that TF plays a critical role in mediating arterial thrombosis. 21,35,36 Intriguingly, celecoxib treatment has been shown to increase TF expression in heart and lung and to increase plasma TF activity, 14 suggesting that decreased prostanoid levels may result in TF upregulation.…”
Section: Discussionmentioning
confidence: 99%
“…11 By genetically reducing either TF in all cells of the vessel wall or knocking out specifically TF in VSMCs, 86 time to thrombotic occlusion was prolonged. Interestingly, selective blockade of TF in circulating cells did not affect thrombosis in the same model, suggesting a pivotal role of vessel wall TF in thrombus formation at least in large conduit arteries.…”
Section: Tf and Thrombosismentioning
confidence: 99%
“…In the current view of thrombus formation, exposure of tissue factor (TF) in the injured vessel wall is a crucial event that initiates thrombosis in high-flow vessels, such as the carotid artery (1,2). In vitro studies demonstrate that TF procoagulant activity is tightly regulated, and TF is switched from a cryptic, nonactive state to a decrypted, active state by a number of cellular agonists or manipulations (3), but the mechanisms of TF decryption and the relevance of these in vitro findings for thrombosis remain a matter of ongoing debate (4)(5)(6)(7)(8)(9)(10).…”
Section: Introductionmentioning
confidence: 99%