1979
DOI: 10.3109/02841867909128223
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Vascular Structure of Experimental Tumours: Appearances in scanning electron microscope

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Cited by 18 publications
(6 citation statements)
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“…Additionally, the carcinoma cell density was signi®cantly lower in the lower central region than in the upper peripheral region. It has been shown that in transplantable experimental tumours in rodents, the relative vascular volume decreased toward the centre of the tumour which became avascular and necrotic [18]. However, the central region in this study showed no massive necrosis histologically, but rather an invasive carcinoma growth with an increased ®brous stroma.…”
Section: Discussioncontrasting
confidence: 50%
“…Additionally, the carcinoma cell density was signi®cantly lower in the lower central region than in the upper peripheral region. It has been shown that in transplantable experimental tumours in rodents, the relative vascular volume decreased toward the centre of the tumour which became avascular and necrotic [18]. However, the central region in this study showed no massive necrosis histologically, but rather an invasive carcinoma growth with an increased ®brous stroma.…”
Section: Discussioncontrasting
confidence: 50%
“…More recently, microangiography (Eddy ]976) and resin casts combined with scanning electron microscopy (Egawa 1979) have allowed the investigation of very small details of the microvasculature. These studies have shown that tumors have a characteristic vascular architecture, which is probably determined by the growth pattern of the tumor cells (Warren 1979a).…”
mentioning
confidence: 99%
“…These studies have shown that tumors have a characteristic vascular architecture, which is probably determined by the growth pattern of the tumor cells (Warren 1979a). Dilated, convoluted, or tapering vessels are common in malignant tumors (Egawa 1979).…”
mentioning
confidence: 99%
“…Similar models were proposed by Burton [1966] who assumed that nutrition was available only by diffusion, but ignored the role of the vascular system; Summers [ 1966] suggested that growth rate depended on the functional area of the capillary bed, but did not consider changes in blood flow during tumor growth. It may be assumed [Egawa et al, 1979;Jain et al, 1979] that specific blood flow (ml/g tumor) decreases with the rapid expansion of the neoplastic tissue or, in other words, blood perfusion and delivery of nutrition to tumor cells and consequently growth rate of the tumor depend on the size of the neoplasm [Brammer et al, 1979], Tumor growth may thus be divided into three phases: (1) the starting period during which delivery of nutrition is sufficient for all neoplastic cells; (2) an intermediate period during which the total blood flow still uniformly supplies the growing tissue but does not completely satisfy all the cell's requirements; (3) the third phase during which the neoplastic mass largely exceeds the possibility of an adequate supply of nutrition.…”
Section: Mathematical Models O F Walker 256jb Growth Kineticsmentioning
confidence: 99%
“…The accumulated evidence [5o«g and Levitt, 1971;Song et al, 1972;Song, 1978;Egawa et al, 1979] on differences in blood circulation in the tumqr capillary system induced us to analyze a 'tumor perfusion' dependent model.…”
Section: Introductionmentioning
confidence: 99%