Vascular supply of the femoral head in sheep—Implications for the ovine femoroacetabular impingement model

Tannast, Moritz; Wolfer, Nadja; Ryan, Michael K.; Nuss, Katja; Rechenberg, Brigitte von; Steppacher, Simon D.

doi:10.1002/jor.23897

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…After an H-shaped capsulotomy, we performed the femoral osteochondroplasty with curved chisels and a high-speed burr (Air Pen Drive; DePuy Synthes) until impingement-free ROM was established [33]. This approach reportedly prevents laceration of the retinacular vessels, which ensure the vascular supply to the femoral head [33,40]. After the second surgery, the sheep were kept in the suspension device for only 2 weeks.…”

Section: Description Of Experimentsmentioning

confidence: 99%

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Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Schmaranzer

Arendt

Liechti

et al. 2018

Clin Orthop Relat Res

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Background Biochemical MRI of hip cartilage such as delayed gadolinium-enhanced MRI of cartilage (dGEM-RIC) and T2 mapping is increasingly used to judge cartilage quality in the assessment of femoroacetabular impingement (FAI). The current evidence is sparse about which of these techniques yields a stronger correlation with histologic cartilage degeneration because of the difficulty in validating biochemical MRI techniques against histology in the clinical setting. Recently, an experimental ovine FAI model was established that induces chondrolabral damage and offers a validated platform to address these limitations. Questions/purposes In a sheep model, we asked: (1) Do dGEMRIC and/or T2 values of acetabular and femoral cartilage correlate with histologic cartilage degeneration as assessed with the Mankin score? (2) Do simultaneously measured dGEMRIC and T2 values correlate in an experimental ovine FAI model? Methods We performed an experimental pilot study on five female Swiss Alpine sheep (10 hips) that underwent postmortem MRI, including biochemical cartilage sequences, after a staged FAI correction had been performed on one side. No surgery was performed on the contralateral side, which The institution of one or more of the authors (BvR) has received, during the study period, funding from the Swiss National Science Foundation. One of the authors certifies that he (FS), or a member of his immediate family, has received or may receive grants, during the study period, in an amount of USD 10,000 to USD 100,000 from the Swiss National Science Foundation (Bern, Switzerland), outside the submitted work. One of the authors certifies that he (MT), or a member of his immediate family, has received or may receive grants, during the study period, in an amount of more than USD 1,000,001 from the Swiss National Science Foundation for the conduct of this work. Clinical Orthopaedics and Related Research® neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA approval status, of any drug or device before clinical use. Each author certifies that his or her institution approved the animal protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.

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Section: Description Of Experimentsmentioning

confidence: 99%

“…1D). Like with FAI in human beings, a cam resection can be performed without impairing the mechanical stability [24,33] and the blood supply [33,40] to the femoral head ( Fig. 1E).…”

Section: Introductionmentioning

confidence: 99%

Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Schmaranzer

Arendt

Liechti

et al. 2018

Clin Orthop Relat Res

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“…This aims to provide a greater understanding of the artery itself and its environment which may aid the design of safer, personalized and patient‐specific PAD therapies (Ansari et al, 2013). This study uses an ovine model to investigate arterial morphology, which are commonly used in pilot research for human stenting as they possess comparable arterial hindlimb anatomy (Byrom et al, 2010; Schleimer et al, 2018; Swartz & Andreadis, 2013; Tannast et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Quantitative and large‐format histochemistry to characterize peripheral artery compositional gradients

Nguyen,

Brooks‐Richards,

Ren

et al. 2023

Microscopy Res & Technique

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The femoropopliteal artery (FPA) is a long, flexible vessel that travels down the anteromedial compartment of the thigh as the femoral artery and then behind the kneecap as the popliteal artery. This artery undergoes various degrees of flexion, extension, and torsion during normal walking movements. The FPA is also the most susceptible peripheral artery to atherosclerosis and is where peripheral artery disease manifests in 80% of cases. The connection between peripheral artery location, its mechanical flexion, and its physiological or pathological biochemistry has been investigated for decades; however, histochemical methods remain poorly leveraged in their ability to spatially correlate normal or abnormal extracellular matrix and cells with regions of mechanical flexion. This study generates new histological image processing pipelines to quantitate tissue composition across high‐resolution FPA regions‐of‐interest or low‐resolution whole‐section cross‐sections in relation to their anatomical locations and flexions during normal movement. Comparing healthy ovine femoral, popliteal, and cranial‐tibial artery sections as a pilot, substantial arterial contortion was observed in the distal popliteal and cranial tibial regions of the FPA which correlated with increased vascular smooth muscle cells and decreased elastin content. These methods aim to aid in the quantitative characterization of the spatial distribution of extracellular matrix and cells in large heterogeneous tissue sections such as the FPA.Research Highlights Large‐format histology preserves artery architecture. Elastin and smooth muscle content is correlated with distance from heart and contortion during flexion. Cell and protein analyses are sensitive to sectioning plane and image magnification.

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Preclinical evaluation of vascular closure devices

Perkins,

2024

Front. Cardiovasc. Med.

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Vascular closure devices (VCDs) are a diverse class of cardiovascular devices intended to achieve hemostasis following arteriotomy in the common femoral artery for diagnostic and therapeutic interventional procedures. While the preclinical evaluation of VCDs parallel that of many other cardiovascular devices, there are device-specific nuances and model-specific technical considerations in assessing in vivo performance and handling, determining safety, and satisfying regulatory requirements. Despite the multi-decade use and continued development of novel VCD technologies, there is a paucity of published literature on their preclinical evaluation. This review intends to help mitigate this gap through a discussion of conventional animal models, their attributes and limitations, and standards in the in vivo assessment of performance and safety of VCDs.

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Vascular supply of the femoral head in sheep—Implications for the ovine femoroacetabular impingement model

Cited by 4 publications

References 30 publications

Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Quantitative and large‐format histochemistry to characterize peripheral artery compositional gradients

Preclinical evaluation of vascular closure devices

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