Vascular-Targeted Photodynamic Therapy (VTP)

Kamarulzaman, Ezatul Ezleen; Benachour, Hamanou; Barberi‐Heyob, Muriel; Frochot, Céline; Wahab, Habibah A.; Guillemin, François; Vanderesse, Régis

doi:10.5772/22935

Cited by 1 publication

(1 citation statement)

References 120 publications

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“…Vascular damage due to VTP results in vessel constriction, blood flow stasis, and thrombus formation, which consequently blocks the supply of oxygen and nutrients, causing tumor necrosis [3]. The advantages of VTP over traditional photodynamic therapy include: (1) the use of hydrophilic PSs, which, due to their short retention time, do not generate adverse photosensitization of a patient; (2) the rapid localization of a PS in endothelium; (3) the availability of molecular oxygen required for a photochemical reaction; (4) the amplified effect on tumor cells resulting from the supply of multiple tumor cells through a single vessel [3,4]. Currently, three vascular-targeted photosensitizers, namely palladium bacteriopheophorbide (TOOKAD ® ), its water-soluble derivative padeliporfin (WST11), and verteporfin (Visudyne ® ), are approved for clinical use [5,6].…”

Section: Introductionmentioning

confidence: 99%

Zinc-Substituted Pheophorbide A Is a Safe and Efficient Antivascular Photodynamic Agent

2022

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The present study focuses on the photodynamic activity of zinc-substituted pheophorbide a against human endothelial cells. Previously, zinc pheophorbide a has been shown to be a very potent photosensitizer but also a strong albumin binder. Binding to albumin significantly reduces its availability to cancer cells, which may necessitate the use of relatively high doses. Here we show that zinc pheophorbide a is very effective against vascular endothelial cells, even in its albumin-complexed form. Albumin complexation increases the lysosomal accumulation of the drug, thus enhancing its efficiency. Zinc pheophorbide a at nanomolar concentrations induces endothelial cell death via apoptosis, which in many cases is considered a desirable cell death mode because of its anti-inflammatory effect. Additionally, we demonstrate that in comparison to tumor cells, endothelial cells are much more susceptible to photodynamic treatment with the use of the investigated compound. Our findings demonstrate that zinc pheophorbide a is a very promising photosensitizer for use in vascular-targeted photodynamic therapy against solid tumors, acting as a vascular shutdown inducer. It can also possibly find application in the treatment of a range of vascular disorders. Numerous properties of zinc pheophorbide a are comparable or even more favorable than those of the well-known photosensitizer of a similar structure, palladium bacteriopheophorbide (TOOKAD®).

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