Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancer

Prickett, Whitney M.; Rite, Brent D. Van; Resasco, Daniel E.; Harrison, Roger G.

doi:10.1088/0957-4484/22/45/455101

Cited by 20 publications

(7 citation statements)

References 26 publications

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“…Having been washed, only NPs bound to the cells can response to the NIR light and induce hyperthermia damage. The tumortargeting of tumor-target molecules conjugated nanostructures has been widely proved [16,17,27] . Consistent with the reports, our data demonstrate that 15P-PPy-NPs can efficiently bind to and ablate the SK-OV-3 cells but not the HL-7702 cells or HepG2 cells.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that anti-Her2 carbon nanotubes can selectively bind to the breast tumor cells which highly expressed Her2 receptors and efficiently induce the hyperthermia ablation of tumor cells primarily bound on the carbon nanotubes [16] . F3 peptide conjugated single-walled carbon nanotubes were also reported to have the ability to selectively target the nucleolin and expressed in the tumor vasculature [17] . The above evidence further warrants the possibility of localized tumor therapy by the tumor-targeted molecule conjugated nanostructures.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of 15P-conjugated PPy-modified gold nanoparticles and their application to photothermal therapy of ovarian cancer

Wang

et al. 2014

Chem. Res. Chin. Univ.

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In this work, we synthesized the polypyrrole(PPy) modified gold nanoparticles and demonstrated their negligible cytotoxicity in vitro. These nanoparticles have also been demonstrated to efficiently ablate different kinds of tumor cells in vitro under the irradiation of the near-infrared laser. When the PPy modified gold nanoparticles were conjugated with the tumor-targeted molecule of 15P(sequence: SHSWHWLPNLRHYAS), these conjugates displayed hyperthermia effects on the human ovarian cancer cell line SK-OV-3 cells in vitro under the irradiation of near-infrared laser, showing great tumor-targeted treatment efficiency. To determine the potential hyperthermia effect of PPy modified gold nanoparticles or 15P-conjugate on tumor cells in vivo, the SK-OV-3 cells were used to induce the subcutaneous tumor-bearing nude mice. The significant inhibition effects of near-infrared laser mediated PPy modified gold nanoparticles or 15P-conjugate on the tumor growth were observed. These composite results suggest that the 15P-conjugated PPy modified gold nanoparticles exhibit great biocompatibility, particularly tumor-targeted effect and the effective photothermal ablation of tumor cells, which warrants the potential therapeutic value of this conjugate for further application to the in vivo localized tumor therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of 15P-conjugated PPy-modified gold nanoparticles and their application to photothermal therapy of ovarian cancer

Wang

et al. 2014

Chem. Res. Chin. Univ.

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“…F3 was also conjugated to carbon nanotubes for near-infrared light therapy of breast cancer. The conjugate was actively internalized in MCF-7 and HAAE-1 endothelial dividing cells resulting in significant cell death further enhanced by near-infrared laser treatment, an effect that was not observed in nondividing confluent endothelial cells [89]. F3 targeted liposomes showed their efficacy to deliver anti-eGFPsiRNA and to down-regulate GFP in MDA-MB-435 cells and angiogenic endothelial cells HMEC-1.…”

Section: F3 Peptide Conjugated Nps Targeting Nclmentioning

confidence: 97%

Nanoparticles Functionalized with Ligands of Cell Surface Nucleolin for Cancer Therapy and Diagnosis

Destouches¹

2015

J Nanomed Nanotechnol

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Conventional cancer chemotherapies are often limited by their non-targeted nature and their inadequate delivery to the tumor affecting the normal tissues and leading to toxic adverse effects. In order to improve the anticancer efficacy and safety of these drugs, as well as the diagnosis capacity of imaging agents, nanoparticles drug delivery system has been developed combining ligands enabling tumor targeting at a cellular level and drug carrier capacity. Nucleolin (NCL) is a multifunctional protein that could shuttle from nucleolus to nucleoplasm, cytoplasm and cell surface. This ribonucleo protein over expressed at the cell surface of cancer cells is involved in many cancer processes supporting tumorigenesis such as cell proliferation and apoptosis. Additionally, NCL expression is enhanced in angiogenic vessels, enabling multi-targeting strategies toward the tumor microenvironment. In this context, several compounds targeting NCL, such as the aptamer AS1411, the peptide F3 and the multivalent pseudopeptide N6L, have been developed and investigated for cancer therapy. Due to their cancer cell targeting capacities, these compounds have been evaluated to mediate highly specific and effective nanoparticles for drug delivery to the tumor. In this report, we present a review of literature focusing on drug-loaded nanoparticles conjugated with these nucleolin ligands, strikingly emphasizing the success of such a strategy.

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“…Nucleolin, another angiogenic marker, is highly expressed on tumor blood vessels relative to normal vasculatures . A 31‐amino acid (F3 peptide) as well as a DNA aptamer (AS1411) that recognize cell surface nucleolin have been utilized for the development of nucleolin‐targeting nanoparticles . These nanoparticles effectively eliminated angiogenesis and blocked tumor growth.…”

Section: Regulating the Tumor Stroma With Nanoparticle Therapeutics Fmentioning

confidence: 99%

Modifying the tumor microenvironment using nanoparticle therapeutics

Roy

2016

WIREs Nanomed Nanobiotechnol

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Treatment of cancer has come a long way from the initial “radical surgeries” to the multi-modality treatments. For the major part of the last century, cancer was considered as a mono-cellular disorder, and treatment strategies were designed according to that hypothesis. However, the mortality rate from cancer continued to be high and a comprehensive treatment remained elusive. Recent progress in research has demonstrated that tumors are a complex network of neoplastic and non-neoplastic cells. The non-neoplastic cells, which are collectively called stroma, assist in tumor survival and progression. It has been shown that disrupting the tumor-stromal balance leads to significant effects on the tumor survival, and effective treatment can be achieved by targeting one or more of the stromal components. In this review, we summarize the roles of various stromal components in promoting tumor progression, and discuss innovative nanoparticle-mediated drug targeting strategies for stromal depletion and the subsequent effects on the tumors. Perspectives and the future directions are also provided.

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Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancer

Cited by 20 publications

References 26 publications

Synthesis of 15P-conjugated PPy-modified gold nanoparticles and their application to photothermal therapy of ovarian cancer

Synthesis of 15P-conjugated PPy-modified gold nanoparticles and their application to photothermal therapy of ovarian cancer

Nanoparticles Functionalized with Ligands of Cell Surface Nucleolin for Cancer Therapy and Diagnosis

Modifying the tumor microenvironment using nanoparticle therapeutics

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