The paper presents the results of application of ozone-oxygen mixture in the comprehensive treatment of 68 elderly patients with ischemic heart disease with stable I-II functional class angina. Ozone synthesis was carried out on the ozone therapeutic installation UOTA-60-01 «Medozon», Moscow. The therapy was carried out in the form of intravenous infusion of ozonized physiological solution with ozone concentration of 2-4 mg/l, 3 times per week, in the amount of 7 procedures in patients receiving nitrates, or beta blockers, or inhibitors of angiotensin converting enzyme. The results of the study indicate a high clinical efficacy of the method of ozone therapy, which is a qualitatively new approach in restorative treatment of elderly patients with ischemic heart disease.