Vascular tumors of infancy and childhood: beyond capillary hemangioma

North, Paula E.; Waner, Milton; Buckmiller, Lisa M.; James, Charles A.; Mihm, Martín C.

doi:10.1016/j.carpath.2006.03.001

Cited by 109 publications

(97 citation statements)

References 59 publications

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“…[1][2][3] The lesions have unique growth characteristics, typically being absent or barely noticeable at birth, followed by a period of rapid growth and subsequent involution. The proliferating phase is characterized by abundant immature endothelial cells and adjacent pericyte-like cells ( Figure 1A), whereas the involuting phase is characterized by fewer and larger capillary-like vessels surrounded by connective tissue ( Figure 1B).…”

mentioning

confidence: 99%

Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

Calicchio

Collins

Kozakewich

2009

The American Journal of Pathology

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Infantile hemangiomas are characterized by rapid capillary growth during the first year of life followed by involution during early childhood. The natural history of these lesions creates a unique opportunity to study the changes in gene expression that occur in the vessels of these tumors as they proliferate and regress. Here we use laser capture microdissection and genome-wide transcriptional profiling of vessels from proliferating and involuting hemangiomas to identify differentially expressed genes. Relative to normal placental vessels, proliferating hemangiomas were characterized by increased expression of genes involved in endothelial-pericyte interactions, such as angiopoietin-2 (ANGPT2), jagged-1 (JAG1), and notch-4 (NOTCH4), as well as genes involved in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing receptor (plexinC1), and an ephrin receptor (EPHB3). Insulin-like growth factor binding protein-3 (IGFBP3) was down-regulated in proliferating hemangiomas. Involuting hemangiomas were characterized by the expression of chronic inflammatory mediators, such as the chemokine, stromal cellderived factor-1 (SDF-1), and factors that may attenuate the angiogenic response, such as a member of the Down syndrome critical region (DSCR) family. The identification of genes differentially expressed in proliferating and involuting hemangiomas in vivo will contribute to our understanding of this vascular lesion, which remains a leading cause of morbidity in newborn children.

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confidence: 99%

Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

Calicchio

Collins

Kozakewich

2009

The American Journal of Pathology

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“…1 Patogenezi tam olarak belirlenememiş olan kapiller hemanjiomların plasenta dokusu ile benzer immünohistokimyasal özellikler göstermesi bu lezyonların plasenta kökenli olduğu görüşünü ortaya atmış olmakla beraber bu henüz tam olarak kesinlik kazanmamıştır. 8,9 Bu iyi huylu ve kendiliğinden gerileme hatta kaybolma eğilimindeki vasküler tümörlerin en önemli ve dikkat edilmesi gereken özelliği %46-%80 oranında bildirilen oftalmik komplikasyonlara neden olabilmeleridir. 3 Perioküler kapiller hemanjiomlar, yüksek astigmatizma, anizometropi ve ambliyopi yanı sıra ekstraoküler kasların tutulması nedeniyle ya da sekonder olarak kaymaya yol açabilirler.…”

Section: Konjenital Kapiller Cilt Hemanjiomlarıunclassified

“…1,2,7,9,14,15 Anjiogenez inhibitörü olan rekombinant interferon alfanın intralezyoner enjeksiyonu denenmiş ve etkin olduğu saptanmış olmasına rağmen irreversibl spastik diplejiye neden olabilmesi nedeniyle sadece hayatı tehdit eden hemanjiomlarda kullanılmalıdır. 16 İmmunmodülatuar bir ajan olan imikomodun (Aldara %5 Krem, Meda Pharma İlaç) topikal kullanımının da kapiller hemanjiomlarda klinik regresyonu tetiklediği bildirilmekle birlikte çocukluk çağında kullanımına ait güvenilirlik verileri kısıtlıdır.…”

Section: Konjenital Kapiller Cilt Hemanjiomlarıunclassified

Perioküler Bölge Hemanjiyomlarının Tedavisinde Güncel Yaklaşımlar

Palamar¹

2014

tjo

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“…11 Capillary hemangiomas were once considered a subtype of infantile hemangiomas but are now considered a separate diagnostic entity, often renamed congenital nonprogressive hemangiomas. 8,20,21 These tumors typically display capillary lobules separated by fibrous tissue instead of the normal tissue that is seen in infantile hemangioma. In addition, these are not GLUT1-positive.…”

Section: 29mentioning

confidence: 99%

“…Infantile hemangiomas are further classified into superficial, deep, or compound categories. 18 Although cutaneous hemangiomas are the most common tumor of infancy, affecting 3%-10% of all children, 20 intradural hemangiomas are much less common. There are multiple reports of spinal extradural 5,10,12 and intradural 8,9,14,15,17,22,23,26 hemangiomas in adults.…”

mentioning

confidence: 99%

Spontaneous resolution of an infantile hemangioma in a dorsal root ganglion

Hervey-Jumper¹,

McKeever²,

Gebarśki

et al. 2011

FOC

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Infantile hemangiomas are tumors commonly seen in children. Few authors have reported infantile hemangiomas affecting the CNS, and there are no prior reports detailing spontaneous resolution of a histologically proven juvenile hemangioma within a dorsal root ganglion. The authors report the case of a newborn boy with a large cutaneous hemangioma in the midline of his back. Spinal MR images were obtained to rule out associated spinal cord tethering, and an intradural spinal lesion was unexpectedly discovered. Biopsy revealed an intradural infantile hemangioma within the dorsal root ganglion, and, based on this diagnosis, no resection was performed. Sixteen months following the biopsy, the cutaneous hemangioma had become involuted and the intradural hemangioma had completely resolved. The behavior of the intradural component in this case follows the natural history of many cutaneous infantile hemangiomas.

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Vascular tumors of infancy and childhood: beyond capillary hemangioma

Cited by 109 publications

References 59 publications

Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

Perioküler Bölge Hemanjiyomlarının Tedavisinde Güncel Yaklaşımlar

Spontaneous resolution of an infantile hemangioma in a dorsal root ganglion

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