Vascularised Fibular Graft Reconstruction Following Resection of First Metatarsal Osteosarcoma: Case Report

Borthakur, Bibhuti Bhusan; Bannoth, Srinivas; Boro, Sumanjit; Purkayastha, Joydeep; Talukdar, Anjan Kumar; Kalita, Deepjyoti

doi:10.1007/s13193-020-01060-3

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…34,35 Few reports exist on the use of autologous vascularized fibula grafts, either free or pedicled, for forefoot reconstruction. Borthakur et al 37 described vascularized free fibula transfer after resection of a first ray osteosarcoma. Toriyama et al 38 reported concomitant first and second metatarsal reconstruction following resection for chondrosarcoma using a free vascularized double-barreled fibula graft, and Toma et al 39 reported a series of 6 cases of metatarsal primary bone tumors resected and reconstructed with a free vascularized fibula graft, including the first and lesser rays.…”

Section: Discussionmentioning

confidence: 99%

Adamantinoma-like Variant of Ewing Sarcoma in the Metatarsal Bone After Chemotherapy: Report of a Case Successfully Treated with Pedicled Osteocutaneous Fibular Transfer

et al. 2021

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Adamantinoma-like Ewing sarcoma is a rare variant of Ewing sarcoma with histologic and immunohistochemical evidence of squamous differentiation. This variant most commonly occurs in the head and neck region with a few cases reported in the long bones of the limbs. It may be associated with poorer clinical outcome and could pose a diagnostic challenge, particularly if it occurs in older patients or as a metastatic lesion. We present a case of Ewing sarcoma in the metatarsal of an 11-year-old boy that manifested adamantinoma-like morphology after neoadjuvant chemotherapy. Chemotherapy has been reported to induce neuronal maturation and rhabdoid morphology in cases of Ewing sarcoma, but no reports of treatment-induced squamous differentiation with P40/P63 expression have been demonstrated. This is also the first documented case treated with a pedicled osteocutaneous fibular transfer in a metatarsal malignancy, which is usually treated by either ray or below-knee amputation.

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Section: Discussionmentioning

confidence: 99%

Adamantinoma-like Variant of Ewing Sarcoma in the Metatarsal Bone After Chemotherapy: Report of a Case Successfully Treated with Pedicled Osteocutaneous Fibular Transfer

et al. 2021

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“…34,35 Few reports exist on the use of autologous vascularized bula grafts, either free or pedicled, for forefoot reconstruction. Borthakur et al 37 described vascularized free bula transfer after resection of a rst ray osteosarcoma. Toriyama et al 38 reported concomitant rst and second metatarsal reconstruction following resection for chondrosarcoma using a free vascularized double-barreled bula graft, and Toma et al 39 reported a series of 6 cases of metatarsal primary bone tumors resected and reconstructed with a free vascularized bula graft, including the rst and lesser rays.…”

Section: Discussionmentioning

confidence: 99%

Adamantinoma-like variant of Ewing sarcoma in the metatarsal bone after chemotherapy: Report of a case successfully treated with a pedicled osteocutaneous fibular transfer

Marais

Saini

Ferreira

et al. 2021

Preprint

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Adamantinoma-like Ewing sarcoma is a rare variant of Ewing sarcoma known to have histologic and immunohistochemical evidence of squamous differentiation. This variant most commonly occurs in the head and neck region with a few cases reported in long bones of the limbs. It may be associated with poorer clinical outcome and could pose a diagnostic challenge(s) particularly if it occurs in older patients or as a metastatic lesion. We present a case of Ewing sarcoma in the metatarsal of an 11 year old boy that manifested adamantinoma-like morphology after neo-adjuvant chemotherapy. Chemotherapy has been reported to induce neuronal maturation and rhabdoid morphology in cases of Ewing sarcoma, but no reports of treatment induced squamous differentiation with P40/P63 expression have been demonstrated. This is also the first documented case to use a pedicled osteocutaneous fibular transfer in a metatarsal malignancy, which is usually treated by either ray or below knee amputation.

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“…Few reports exist on the use of autologous vascularised bula grafts, either free or pedicled, for forefoot reconstruction. Borthakur et al described vascularised free bula transfer post resection of a rst ray osteosarcoma (38). Toriyama et al reported concomitant rst and second metatarsal reconstruction following resection for chondrosarcoma using a free vascularised double-barrelled bula graft (39), and Toma et al reported a series of six cases of metatarsal primary bone tumours resected and reconstructed with free vascularised bula graft, including the rst and lesser rays (40).…”

Section: Discussionmentioning

confidence: 99%

Adamantinoma-like Ewing Sarcoma in a Metatarsal Bone After Chemotherapy Treated with an Osteocutaneous Fibular Transfer: A Case Report.

Marais

Saini

Ferreira

et al. 2020

Preprint

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Background: Adamantinoma-like Ewing sarcoma is a rare variant of Ewing sarcoma known to have cytokeratin expression and squamous differentiation. It occurs more commonly in the head and neck region with only a few cases reported in long bones of the limbs. It also harbours EWSR1-FLI1 gene fusion which is required for the diagnosis of Ewing sarcoma. We present a case of Ewing sarcoma that manifested Adamantinoma-like morphology only post chemotherapy. Chemotherapy has been reported to induce neuronal maturation and rhabdoid morphology in cases of Ewing sarcoma, but no reports of treatment induced squamous differentiation with P40/P63 expression have been demonstrated to date.Case presentation: An 11 year old boy presented with a one year history of an enlarging painless mass over the left first metatarsal. Initial biopsy showed Ewing sarcoma with typical morphological features and EWSR1 rearrangement confirmed on fluorescent in-situ hybridization. The patient underwent neo-adjuvant chemotherapy and a subsequent wide local excision with an ipsilateral pedicled osteocutaneous fibula transfer. Subsequent histological examination showed frank squamous differentiation in the soft tissue component with keratin pearl formation and P40/P63 expression which was not observed in the initial biopsy and is compatible with Adamantinoma-like Ewing sarcoma.Conclusion: This case describes Adamantinoma-like Ewing sarcoma with P40/P63 expression after neo-adjuvant chemotherapy treatment. This immunophenotype was not apparent on the initial biopsy. It remains uncertain as to the reason for this change. This variant carries a poorer clinical outcome compared to the more conventional variant and could pose a diagnostic challenge(s) particularly if it occurs in an older patient or as a metastatic lesion.

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Vascularised Fibular Graft Reconstruction Following Resection of First Metatarsal Osteosarcoma: Case Report

Cited by 3 publications

References 6 publications

Adamantinoma-like Variant of Ewing Sarcoma in the Metatarsal Bone After Chemotherapy: Report of a Case Successfully Treated with Pedicled Osteocutaneous Fibular Transfer

Adamantinoma-like Variant of Ewing Sarcoma in the Metatarsal Bone After Chemotherapy: Report of a Case Successfully Treated with Pedicled Osteocutaneous Fibular Transfer

Adamantinoma-like variant of Ewing sarcoma in the metatarsal bone after chemotherapy: Report of a case successfully treated with a pedicled osteocutaneous fibular transfer

Adamantinoma-like Ewing Sarcoma in a Metatarsal Bone After Chemotherapy Treated with an Osteocutaneous Fibular Transfer: A Case Report.

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