Vascularization of Experimental Tumours

Reinhold, H; Berg-Blok, A. Van Den

doi:10.1002/9780470720813.ch7

Cited by 10 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This hostile microenvironment is largely determined by an abnormal tumor microcirculation. When considering the continuous and indiscriminate formation of a vascular network in growing tumors, the following pathogenetic mechanisms can be involved either alone or in combination: Angiogenesis by endothelial sprouting from pre-existing venules [15,16]. …”

Section: Vessel Formation In Malignant Tumorsmentioning

confidence: 99%

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Multhoff

Radons²,

Vaupel

2014

Cancers

View full text Add to dashboard Cite

Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance.

show abstract

Section: Vessel Formation In Malignant Tumorsmentioning

confidence: 99%

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Multhoff

Radons²,

Vaupel

2014

Cancers

View full text Add to dashboard Cite

show abstract

“…For example, structurally, the vessel wall is incomplete, lack pericytes and biological receptors; the vessels are often elongated and exhibit an arteriovenous shunt; the vascular density is chaotic and the intercapillary space is expanded. Functionally, the vessels are more fragile; the speed and direction of blood flow is unstable; the vascular permeability is increased, which may result in hemoconcentration and high interstitial fluid pressure [7, 14]. When increased vascular permeability is combined with the often malfunctioned lymphatic drainage, it results in the EPR effect, which is used in most antitumor nano systems [15-17].…”

Section: Tumor Vasculature and Angiogenesismentioning

confidence: 99%

Cancer nanomedicines targeting tumor extracellular pH

Tian

Bae

2012

Colloids and Surfaces B: Biointerfaces

113

View full text Add to dashboard Cite

Tumors have been a highlight in the research of nanomedicine for decades. Despite all the efforts in the decoration of the nano systems, tumor specific targeting is still an issue due to the heterogeneous nature of tumors. Hypoxia is frequently observed in solid tumors. The consequent acidification of tumor extracellular matrices may bring new insight to tumor targeting. In this review, we present the polymeric nano systems that target tumor extracellular pH (pHe).

show abstract

The vascular network of tumours — what is it not for?

Sivridis

Giatromanolaki

Koukourakis

2003

The Journal of Pathology

View full text Add to dashboard Cite

It is becoming almost a dogma that tumours cannot grow beyond 1-2 mm(3) unless they are supported by a rich vascular supply 1. It is true that tumours promote angiogenesis and that highly vascularized carcinomas have, in general, a more aggressive clinical course than carcinomas of low vascularization 23. However, a study of intratumoral angiogenesis reveals that the newly formed vessels are commonly deprived of those structural qualities that would allow them to perform an optimal oxygenation function 3. Thus, most tumours, irrespective of their angiogenic status, behave as if they were 'hypoxic', urging (via angiogenic mediators) for, what would look paradoxical at first sight, more defective angiogenesis. It is hypothesized that tumour cells can grow into solid neoplasms by exploiting the host's pre-existing vessels, without the need for new blood vessel formation. Neovascularization, however, may be important for tumours with an exophytic pattern of growth as these, by their very nature, lose the host's sheltering stroma. Shifting to anaerobic glycolysis and activation of anti-apoptotic pathways are complementary mechanisms for tumour cell survival and growth. Besides, continuous and indiscriminate production of a defective vascular network ensures an increased metastatic potential since the newly formed intratumoral vessels, simulating venular-like spaces, are easily permeable to tumour cells, facilitating metastases.

show abstract

Vascularization of Experimental Tumours

Cited by 10 publications

References 22 publications

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Cancer nanomedicines targeting tumor extracellular pH

The vascular network of tumours — what is it not for?

Contact Info

Product

Resources

About