Vascularization of primary central nervous system tumors: detection with contrast-enhanced transcranial color-coded real-time sonography.

Bogdahn, Ulrich; Fröhlich, Thomas; Becker, Georg; Krone, A.; Schlief, Reinhard; J, Schürmann; Jachimczak, Piotr; Hofmann, Erich; Roggendorf, Wolfgang; Roosen, K.

doi:10.1148/radiology.192.1.8208926

Cited by 47 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The saccharide agents, applied for blood-pool echo enhancement (Levovist, Schering, Berlin, Germany), have already proved their value [10,11,12]. The favorable acoustic properties of SHU 563A enable stimulated acoustic emission response during ultrasound exposure and the pharmacokinetic properties of a prolonged blood-pool phase and an RES phase enable new diagnostic applications.…”

Section: Discussionmentioning

confidence: 99%

Liver-specific imaging with SHU 563A: Diagnostic potential of a new class of ultrasound contrast media

Bauer¹,

Blomley

Leen

et al. 1999

Eur Radiol

View full text Add to dashboard Cite

The purpose of this study was to evaluate the imaging properties and diagnostic potential of the novel polymeric ultrasound contrast agent SHU 563 A. After i. v. injection, the agent circulates in the blood pool for about 10 min and is then subsequently sequestered by the RES cells predominantly in the liver. The acoustic emission capabilities enable a very sensitive detection during the blood pool phase and after uptake in the RES cells, contributing to differential diagnosis as well as detection of liver lesions. During a multicenter study, 28 patients with liver lesions were examined. In all patients the results were compared to baseline ultrasound and Contrast enhanced Spiral CT. With respect to lesion size and location, very good agreement between SHU 563 A ultrasound and Spiral CT was achieved. Additional lesions could be shown in the RES phase by SHU 563 A enhanced ultrasound. 26 further patients were examined in other indications. The results in all 54 patients indicate good safety and tolerance of SHU 563 without limitations for diagnostic use. SHU 563 A enhanced ultrasound adds significantly to the detection and delineation of focal liver lesions by improving conspicuity due to RES based contrast after uptake.

show abstract

Section: Discussionmentioning

confidence: 99%

Liver-specific imaging with SHU 563A: Diagnostic potential of a new class of ultrasound contrast media

Bauer¹,

Blomley

Leen

et al. 1999

Eur Radiol

View full text Add to dashboard Cite

show abstract

“…Ultrasound has shown intra-operatively [5,8,11,15,22,26,30,32,48,50,59,61,62,64,66,73,76,79,81] and transcranially [6,9,10,17,69,75,77] to be a reliable real-time method in the delineation of tumour tissue before resection, even superior to contrast-enhanced CT or MRI [35,43,47].…”

Section: Introductionmentioning

confidence: 99%

Correlation of intra-operative ultrasound with histopathologic findings after tumour resection in supratentorial gliomas

et al. 1996

View full text Add to dashboard Cite

The aim of this study was to evaluate whether intra-operative ultrasound (= IOUS) is a suitable tool to detect residual tumour tissue after gross total resection in supratentorial gliomas. During a period of 18 months 45 patients with supratentorial gliomas (38 high-grade and 9 low-grade, according to the WHO-grading system [42]) were operated on. A series of 78 biopsies was taken from the resection cavity under continuous sonographic control at the end of surgery. Gross total tumour resection was intended in 34 patients (= 76%). The biopsy specimens were matched with the sonographic features at each biopsy site. The sonographic appearance of the resection margins were classified into 2 groups: (1) Irregular hyperechoic areas extending from the cavity into the iso-echogenic brain tissue and (2) a dense small (< or = 3 mm in diameter) rather regular hyperechoic rim surrounding the resection cavity. 47 out of 53 biopsies taken from hyperechoic areas (group I) (36 high-grade/11 low-grade) revealed solid tumour tissue (= 89%). 34 (= 72%) of these 47 areas were microscopically assessed as inconspicuous by the surgeon. 6 samples (4 high-grade/2 low-grade) contained tumour infiltration zone. 25 biopsies (23 high-grade/2 low-grade) taken from the hyperechoic rim [group 2] were diagnosed as follows: Normal brain tissue in 11, tumour infiltration zone in 8 and solid tumour tissue in 6 cases. Of 34 cases with "gross total removal" according to the surgeon's assessment 25 showed sonographic signs of residual tumour tissue, which was confirmed histologically as solid tumour tissue in 22 of these cases. It is concluded, that IOUS following resection of supratentorial gliomas can detect residual tumour tissue with high specificity and thus improve gross total resection. However, a thin hyperechoic rim surrounding the resection cavity (less than 3 mm in diameter) is a non-specific finding, which can mask thin residual tumour layers and therefore needs further evaluation of its nature.

show abstract

“…In the literature few studies using bedside transcranial US have been performed to evaluate the role of iCEUS in depicting cerebral tumors [29][30][31]. Harrer et al used bedside transcranial CEUS prior to surgery and had been capable of discriminating brain lesions from the brain parenchyma and of partially describing them.…”

Section: Discussionmentioning

confidence: 99%

201 Intraoperative Cerebral Glioma Characterization With Contrast Enhanced Ultrasound

Prada¹,

Mattei²,

Filippini³

et al. 2014

Neurosurgery

View full text Add to dashboard Cite

Background. Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before. Aim. To perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas. Methods. We performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma. An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging. A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria. Results were related to histopathology. Results. We observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase. HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns. Conclusion. Our study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors' biology. CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.

show abstract

Vascularization of primary central nervous system tumors: detection with contrast-enhanced transcranial color-coded real-time sonography.

Abstract: In addition to depiction of primary CNS tumors in B-mode, contrast-enhanced TCCS enables evaluation of vascularization associated with tumor parenchyma.

Cited by 47 publications

References 0 publications

Liver-specific imaging with SHU 563A: Diagnostic potential of a new class of ultrasound contrast media

Liver-specific imaging with SHU 563A: Diagnostic potential of a new class of ultrasound contrast media

Correlation of intra-operative ultrasound with histopathologic findings after tumour resection in supratentorial gliomas

201 Intraoperative Cerebral Glioma Characterization With Contrast Enhanced Ultrasound

Contact Info

Product

Resources

About