2019
DOI: 10.1002/adhm.201900626
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Vascularized and Innervated Skeletal Muscle Tissue Engineering

Abstract: Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, ti… Show more

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Cited by 133 publications
(76 citation statements)
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“…Immediately upon injury damaged myofibers, blood vessels, and neurons undergo necrosis. This is due to membrane damage which permits an influx of extracellular calcium and triggers autodigestion via calcium-dependent proteases such as calpains [30,[48][49][50]. In addition to cellular damage, disruption of the blood vessels and basement membrane surrounding myofibers also occurs upon injury.…”
Section: Destruction/inflammatory Phasementioning
confidence: 99%
See 1 more Smart Citation
“…Immediately upon injury damaged myofibers, blood vessels, and neurons undergo necrosis. This is due to membrane damage which permits an influx of extracellular calcium and triggers autodigestion via calcium-dependent proteases such as calpains [30,[48][49][50]. In addition to cellular damage, disruption of the blood vessels and basement membrane surrounding myofibers also occurs upon injury.…”
Section: Destruction/inflammatory Phasementioning
confidence: 99%
“…Prolonged in vitro culture times make TEMG clinical scalability, cost-effectiveness, off-the-shelf availability, and regulatory compliance more challenging than in situ and in vivo tissue engineering approaches. Implanted TEMGs have resulted in varied degrees of skeletal muscle regeneration, which is likely due to vast assortment of scaffold biomaterials, cell types, culture time and conditions, construct sizes, stimulation regimes, custom bioreactors, and preclinical models evaluated [49].…”
Section: In Vitro Strategies: Developing Mature Tissue Constructs Primentioning
confidence: 99%
“…A variety of approaches including acellular gels [48], cell sheetderived [49], minced muscle [50] or tissue engineering grafts [29] have been proposed for VML treatment. Among these strategies, as described in a recent excellent review on this topic [20], the use of grafts delivered in combination with a myogenic cell source should be preferred to the other methods. In fact, acellular gels, as ultimately demonstrated in a recent study by Corona [51] do not offer any beneficial effect for VML recovery.…”
Section: Discussionmentioning
confidence: 99%
“…These approaches, while promising, are still far from satisfactorily addressing the second key challenge of SMTE -i.e. the development of macroscopic tissue-equivalents of a size suitable for treating volumetric muscle loss (VML): a condition resulting from large traumatic injury or massive surgical ablation upon tumor removal [20,21]. VML, which is characterized by muscular mass loss, functional deficit and permanent disability, is currently treated by surgical tissue transfer (autologous transplantation).…”
Section: Introductionmentioning
confidence: 99%
“…Neither transplant nor other traditional medicine approaches can solve this problem, at least so far, thus prompting muscle-tissue engineering research as a promising solution for these issues. Moreover, the coordinated regeneration of muscle and nerves is needed because of their complex interconnection, mediating motor co-ordination [4].…”
Section: Introductionmentioning
confidence: 99%