Vascularized nerve grafts: an experimental study

Donzelli, R; Capone, Crescenzo; Sgulò, Francesco Giovanni; Mariniello, Giuseppe; Maiuri, Francesco

doi:10.1080/01616412.2016.1198527

Cited by 28 publications

(29 citation statements)

References 13 publications

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“…Rabbits have several advantages as laboratory species. White New Zealand rabbits are recently being used in a variety of experiments, including neuronal anesthetic block (4) , vascularized nerve grafts (5) , orthopedic surgery (6) , and neuronal lesions (7) . Concomitantly, their popularity as pets is also increasing (8) .…”

Section: Introductionmentioning

confidence: 99%

Origin and Antimeric Distribution of the Obturator Nerves in the New Zealand Rabbits

et al. 2019

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New Zealand rabbits are widely used as experimental models and represent an important casuistic in veterinary practices. The musculoskeletal conformation of rabbits frequently leads to the occurrence of lumbosacral lesions with neural involvement. In order to contribute to the comparative anatomy and the understanding of these lesions, the origin and distribution of the obturator nerves of 30 New Zealand rabbits (15 males and 15 females) previously fixed in 10% formaldehyde were studied by dissection. The obturator nerves were originated from the ventral spinal branches of L6 and L7 in 63.3% of the cases, L5 and L6 in 13.4%, only L7 in 13.4%, L7 and S1 in 6.6 % and of L6, L7 and S1 in 3.3%. The spinal segment that most contributed to the formation of the nerve was L7 (86.6% of the nerves). The obturator nerves emitted in all the specimens, a variable number of branches for the internal obturator, external obturator, pectineum, adductor and gracilis muscles. No significant differences were observed between the frequencies of the origin and muscular branches of the obturator nerves when comparing sex and antimers. ResumoCoelhos da raça Nova Zelândia são amplamente usados como modelos experimentais e representam uma parcela importante dos atendimentos em consultórios veterinários. A conformação músculoesquelética dos coelhos torna frequente a ocorrência de lesões lombossacrais com comprometimento neural. Visando contribuir para a anatomia comparada e no entendimento destas lesões, foram estudadas por dissecção a origem e a distribuição dos nervos obturatórios de 30 cadáveres de coelhos da raça Nova Zelândia (15 machos e 15 fêmeas) fixados previamente em formaldeído a 10%. O nervo obturatório formou-se a partir dos ramos ventrais de L6 e L7 em 63,3% dos casos, de L5 e L6 em 13,4%, apenas de L7 em 13,4%, de L7 e S1 em 6,6% e de L6, L7 e S1 em 3,3%. O segmento espinhal que mais contribuiu para a formação do nervo foi L7 (86,6% dos nervos). Os nervos obturatórios emitiram em todos os animais, número variável de ramos para os músculos obturador interno, Palavras-chave: anatomia animal, lagomorfos, Oryctolagus cuniculus, plexo lombossacral, sistema nervoso.

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Section: Introductionmentioning

confidence: 99%

Origin and Antimeric Distribution of the Obturator Nerves in the New Zealand Rabbits

et al. 2019

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“…Other authors argue that nerve flaps are not necessarily advantageous, as nerve grafts rapidly regain a new blood supply in several experimental models. [ 31 ] Some authors add that, although recovery tends to be faster with CNFs, the end functional results are similar with CNFs and NGs. [ 25 , 31 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 31 ] Some authors add that, although recovery tends to be faster with CNFs, the end functional results are similar with CNFs and NGs. [ 25 , 31 ]…”

Section: Introductionmentioning

confidence: 99%

“…These methodological differences make information synthesis challenging. [ 31 ] Finally, even though there are a few side-to-side comparisons of different gap reconstruction methods in the rat hindlimb, using the sciatic nerve, as far as the authors could determine, there is no similar study using the rat forelimb. [ 11 , 23 , 35 ] This is unfortunate, since clinically most peripheral nerve lesions occur in the upper extremity.…”

Section: Introductionmentioning

confidence: 99%

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Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat

et al. 2018

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The aim of this study was to evaluate in the Wistar rat the efficacy of various autologous nerve conduits with various forms of blood supply in reconstructing a 10-mm-long gap in the median nerve (MN) under conditions of local ischemia. A 10-mm-long median nerve defect was created in the right arm. A loose silicone tube was placed around the nerve gap zone, in order to simulate a local ischemic environment. Rats were divided in the following experimental groups (each with 20 rats): the nerve Graft (NG) group, in which the excised MN segment was reattached; the conventional nerve flap (CNF) and the arterialized neurovenous flap (ANVF) groups in which the gap was bridged with homonymous median nerve flaps; the prefabricated nerve flap (PNF) group in which the gap was reconstructed with a fabricated flap created by leaving an arteriovenous fistula in contact with the sciatic nerve for 5 weeks; and the two control groups, Sham and Excision groups. In the latter group, the proximal stump of the MN nerve was ligated and no repair was performed. The rats were followed for 100 days. During this time, they did physiotherapy. Functional, electroneuromyographic and histological studies were performed. The CNF and ANVF groups presented better results than the NG group in the following assessments: grasping test, nociception, motor stimulation threshold, muscle weight, and histomorphometric evaluation. Radial deviation of the operated forepaw was more common in rats that presented worse results in the other outcome variables. Overall, CNFs and ANVFs produced a faster and more complete recovery than NGs in the reconstruction of a 10-mm-long median nerve gap in an ischemic environment in the Wistar rat. Although, results obtained with CNFs were in most cases were better than ANVFs, these differences were not statistically significant for most of the outcome variables.

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“…Это обусловлено некоторым сходством филогенеза ЦНС кролика и человека, а также сроками процес-са миелинизации нервных волокон, которые у большинства млекопитающих, включая приматов, практически заканчивается к моменту родов, т.е. активно протекают в пренатальном периоде, а у человека и кролика они сохраняются и в постнатальном периоде [3][4][5][6][7][8][9][10].…”

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The effect of cellex on regenerative processes in cerebral parenchymal hemorrhage under experimental condition

Korsunskaya¹,

Vlasenko²,

Davydova³

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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A much more pronounced regression of the neurological deficit was observed in the group of animals which were administered cellex. There was a significant increase in volume of active movements in the limbs. No connective tissue changes were observed macroscopically in rabbits of the first group. Besides, the area of destruction decreased in size in comparison with initially diagnosed one. A decline in the rate of the formation of connective tissue was observed in damaged parts of the brain. The microscopic study of the first group showed that the degree of inflammatory and hemodynamic disturbances was much lower and necrosis foci were not detected, however small foci of neoangiogenesis were found.

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Vascularized nerve grafts: an experimental study

Cited by 28 publications

References 13 publications

Origin and Antimeric Distribution of the Obturator Nerves in the New Zealand Rabbits

Origin and Antimeric Distribution of the Obturator Nerves in the New Zealand Rabbits

Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat

The effect of cellex on regenerative processes in cerebral parenchymal hemorrhage under experimental condition

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