Vasculitic polyradiculopathy in systemic lupus erythematosus

Stefurak, Taresa L.; Midroni, Gyl; Bilbao, Juan M.

doi:10.1136/jnnp.66.5.658

Cited by 20 publications

(9 citation statements)

References 10 publications

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“…Nevertheless, the fact that muscle biopsy often reveals vasculitic changes indicates that the underlying pathology is not confined to peripheral nerve. Vasculitis causes peripheral nerve involvement in an acute, subacute or chronic pattern [70,86,128,138]. Recognition of vasculitis as the cause of peripheral neuropathy is important since the disorder is treatable.…”

Section: ■ Neuropathies Associated With Systemic Disorders With Artermentioning

confidence: 99%

Diagnosis of acute neuropathies

Crone

Krarup

2007

J Neurol

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Acute and subacute polyneuropathies present diagnostic challenges since many require prompt initiation of treatment in order to limit axonal degeneration and since an exact and detailed diagnosis is a prerequisite for making the correct choice of treatment. It is for instance of utmost importance to recognize whether the underlying pathological changes are due to demyelination or to axonal degeneration and electrodiagnostic tests can thus in most cases contribute considerably to the securing of an exact diagnosis. The specific and characteristic electrophysiological findings in the different types of acute and subacute neuropathies are discussed, and the various electrophysiological pitfalls and technical problems, which are met in these patients, are mentioned.

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Section: ■ Neuropathies Associated With Systemic Disorders With Artermentioning

confidence: 99%

Diagnosis of acute neuropathies

Crone

Krarup

2007

J Neurol

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“…This may help refine therapy in HIV-uninfected patients with pure immune-mediated motor polyradiculopathy, for example paraneoplastic and other immune ventral root radiculopathies. 5,6,7,26,27,28…”

Section: Resultsmentioning

confidence: 99%

Motor lumbosacral radiculopathy in HIV-infected patients

Moodley

Bill

Patel

2019

South. Afr. j. HIV med.

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BackgroundThis study is a review of the clinical findings and treatment outcome of 11 HIV-infected patients with motor lumbosacral radiculopathy.ObjectivesTo describe the clinical, laboratory, electrophysiological features and treatment outcome in HIV-infected motor lumbosacral radiculopathy which is a rare manifestation of HIV.MethodA retrospective review of HIV-infected patients with motor lumbosacral radiculopathy was performed at Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa between 2010 and 2015.ResultsEleven black African patients met the inclusion criteria. There were six women. The median age was 29 years, the interquartile range (IQR) was 23–41 years, the median duration of symptom progression was 6.5 months (IQR 3–7.5 months). The median CD4 count was 327 cells/µL (IQR 146–457). The cerebrospinal fluid (CSF) median polymorphocyte count was 0 cells/µL (IQR 0 cells/µL – 2 cells/µL), lymphocyte count was 16 cells/µL (IQR 1 cells/µL – 18 cells/µL), glucose level was 3.1 mmol/L (IQR 2.8 mmol/L – 3.4 mmol/L) and protein level was 1.02 g/dL (IQR 0.98 g/dL – 3.4 g/dL). All patients were treated with corticosteroid therapy. Ninety-one per cent recovered fully within 6 months of treatment, the median time for recovery was 3.4 months (IQR 1.8–5.6 months). There were no relapses during the 18-month follow-up.ConclusionHIV-infected patients with motor lumbosacral radiculopathy responded to corticosteroids, with no relapses during the 18-month follow-up period.

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“…Most of the SLE patients reported to date have AIDP. 3,[10][11][12] Rarely, AIDP may be the first manifestation of SLE.…”

Section: Discussionmentioning

confidence: 99%

Acute lumbosacral polyradiculoneuropathy heralding transformation to systemic lupus erythematosus in a patient with discoid lupus

Yıldız

Balaban

Şenel

et al. 2011

Lupus

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Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with which a variety of neuropathic disorders have been associated. Among these, the acute inflammatory demyelinating polyradiculoneuropathy variant of Guillain-Barré syndrome has been well established. However, acute axonal lumbosacral polyradiculoneuropathy accompanied by albuminocytological dissociation in the cerebrospinal fluid has been extremely rarely reported in SLE. We report on a 47-year-old woman with discoid lupus presenting with acute onset of flaccid paraplegia. Extensive investigations suggested the diagnoses of axonal lumbosacral polyradiculoneuropathy and SLE. Treatment with intravenous methylprednisolone and cyclophosphamide resulted in clinical recovery. Development of immune-mediated polyneuropathy in a patient with discoid lupus should forewarn the clinician regarding transformation into the systemic form of the disease.

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Vasculitic polyradiculopathy in systemic lupus erythematosus

Cited by 20 publications

References 10 publications

Diagnosis of acute neuropathies

Diagnosis of acute neuropathies

Motor lumbosacral radiculopathy in HIV-infected patients

Acute lumbosacral polyradiculoneuropathy heralding transformation to systemic lupus erythematosus in a patient with discoid lupus

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