Vasculitis asociadas a anticuerpos anti-citoplasma de neutrófilos: avances en patogenia y tratamiento

Current Treatment of ANCA Vasculitis

“…The etiology of AAV remains poorly understood, and research on their pathogenesis focuses on the role of ANCAs themselves [4].…”

“…Non-treated, they were considered as fatal or life-threatening illnesses. In the last two decades, better knowledge of pathogenic mechanisms and progression in classification criteria improved therapeutic management [3][4][5]. Treatment is usually aggressive, with high-dose corticosteroid therapy combined with immunosuppressive drugs in the major part of cases.…”

“…Treatment is usually aggressive, with high-dose corticosteroid therapy combined with immunosuppressive drugs in the major part of cases. New biologic drugs have been introduced such as rituximab [4]. In this chapter, we will present the update and recent advances in the treatment of AAV.…”