Vasculitis

Travis, William D.

doi:10.1007/978-0-387-68792-6_29

Cited by 5 publications

(1 citation statement)

References 415 publications

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“…Behçet’s syndrome and Wegener’s granulomatosis cause both pulmonary macrovascular and microvascular compromise. However, Churg-Straus syndrome and microscopic polyangiitis appear to be restricted in their impact; where Churg-Strauss syndrome targets medium-sized arteries and veins of the macrocirculation, and microscopic polyaniitis only compromises arterioles, capillaries and venules of the microcirculation 27. Identical results are found in other vasculitides that uncommonly impact the pulmonary circulation: whereas necrotizing sarcoid granulomatosis, Takayasu’s arteritis, and giant cell arteritis cause macrovascular compromise; crytoglobulinemic vasculitis causes microvascular demise.…”

Section: Heterogeneity In the Stimulated Secretion Of Von Willebrand mentioning

confidence: 99%

New Developments in Lung Endothelial Heterogeneity: von Willebrand Factor, P-Selectin, and the Weibel-Palade Body

Ochoa

Stevens

2010

Semin Thromb Hemost

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Quiescent pulmonary endothelium establishes an anti-thrombotic, anti-inflammatory surface that promotes blood flow. However, the endothelium rapidly responds to injury and inflammation by promoting thrombosis and enabling the directed transmigration of inflammatory cells, such as neutrophils, into the alveolar airspace. While the endothelial cell signals responsible for establishing a pro-thrombotic surface are distinct from those responsible for recognizing circulating neutrophils, these processes are highly inter-related. Von Willebrand factor stimulated secretion plays an important role in thrombus formation, while P-selectin surface expression plays a key role in neutrophil binding necessary for transmigration. Both von Willebrand factor and Pselectin are located within Weibel-Palade bodies in pulmonary arteries and arterioles, yet WeibelPalade bodies are absent in capillaries. Despite the absence of the Weibel-Palade bodies, pulmonary capillaries express both von Willebrand factor and P-selectin. The physiological and pathophysiological significance of these observations is unclear. In this review, we address some anatomic and physiologic features that distinguish pulmonary artery, capillary, and vein endothelium. In addition, we review our current understanding regarding the stimulated secretion of von Willebrand factor and P-selectin in pulmonary artery and capillary endothelium. This information is considered in the context of vasculitis and pneumonia, two pathophysiological processes to which the stimulated secretion of von Willebrand factor and P-selectin contribute.

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Section: Heterogeneity In the Stimulated Secretion Of Von Willebrand mentioning

confidence: 99%

New Developments in Lung Endothelial Heterogeneity: von Willebrand Factor, P-Selectin, and the Weibel-Palade Body

Ochoa

Stevens

2010

Semin Thromb Hemost

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Wegener’s Granulomatosis, Pulmonary

O’Hare¹,

Cagle²

2018

Encyclopedia of Pathology

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The Pathologist's Approach to Acute Lung Injury

Beasley¹

2010

Archives of Pathology &Amp; Laboratory Medicine

115

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Context.—Acute lung injury and acute respiratory distress syndrome are significant causes of pulmonary morbidity and are frequently fatal. These 2 entities have precise definitions from a clinical standpoint. Histologically, cases from patients with clinical acute lung injury typically exhibit diffuse alveolar damage, but other histologic patterns may occasionally be encountered such as acute fibrinous and organizing pneumonia, acute eosinophilic pneumonia, and diffuse hemorrhage with capillaritis. Objective.—To review the diagnostic criteria for various histologic patterns associated with a clinical presentation of acute lung injury and to provide diagnostic aids and discuss the differential diagnosis. Data sources.—The review is drawn from pertinent peer-reviewed literature and the author's personal experience. Conclusions.—Acute lung injury remains a significant cause of morbidity and mortality. The pathologist should be aware of histologic patterns of lung disease other than diffuse alveolar damage, which are associated with a clinical presentation of acute lung injury. Identification of these alternative histologic findings, as well as identification of potential etiologic agents, especially infection, may impact patient treatment and disease outcome.

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Vasculitis

Cited by 5 publications

References 415 publications

New Developments in Lung Endothelial Heterogeneity: von Willebrand Factor, P-Selectin, and the Weibel-Palade Body

New Developments in Lung Endothelial Heterogeneity: von Willebrand Factor, P-Selectin, and the Weibel-Palade Body

Wegener’s Granulomatosis, Pulmonary

The Pathologist's Approach to Acute Lung Injury

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