Vasculitis leucocitoclástica inducida por cotrimoxazol

Trimethoprim-Sulfamethoxazole–Induced Type 2 Cryoglobulinemia and Leukocytoclastic Vasculitis

“…6,8 A review of existing literature revealed 3 previously reported cases of an association between trimethoprimsulfamethoxazole and leukocytoclastic vasculitis, of which one had underlying ANCA-positive vasculitis, whereas no other underlying condition was found in the other 2 cases. [9][10][11] Our patient developed mixed cryoglobulinemia (type 2) that was triggered by exposure to trimethoprim-sulfamethoxazole, and the complete investigative workup for type II cryoglobulinemia was unremarkable. Our patient had only cutaneous manifestation presenting as leukocytoclastic vasculitis without systemic involvement.…”