Introduction: Systemic Lupus Erythematous is an autoimmune connective disease that has vascular involvement and can manifest as acute/subacute inflammation as antiphospholipid syndrome. It can result in a predisposition for vascular thromboses and pregnancy complications.Clinical manifestation: 20 years old female presented with fever for two weeks with bluish discoloration of the fingertips while her lower limbs swelled and gained a violaceous rash in a netlike pattern. On examination, she was vitally unstable. Bluish discoloration of the fingertips and lower limbs had bilateral retiform purport and lived racemose. The histopathological examination of the lesions showed both small and medium vessels vasculitis with perivascular inflammation and panniculitis. The patient was treated with analgesics, immunosuppressant (Rituximab), and steroid.
Conclusion:The histopathology examination is the key to make the diagnosis and the mainstay treatment is immunosuppressant.