Vasculitis-related stroke in young as a presenting feature of novel coronavirus disease (COVID19) – Case report

Sousa, Gustavo Celeira de; Sousa, Thiago Celeira de; Sakiyama, Marcelo Akira Kobayashi; Silva, Jeanne Seabra Negrão Lima da; Sousa, Emanuel de Jesus Soares de

doi:10.1016/j.jocn.2020.07.034

Cited by 9 publications

(6 citation statements)

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“…Full-texts of the remaining 222 references were retrieved and screened for eligibility, and this process excluded an additional 115 references as the inclusion criteria was not met. This exclusion included articles with no access 28 , 29 , RT-PCR not clearly stated in the text 30 - 45 , case reports 46 - 97 , case seriess 98 - 113 , repeated datasetss 114 - 118 , and studies in specific groups 119 - 130 . A complete assessment was conducted for 107 references.…”

Section: Resultsmentioning

confidence: 99%

Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis

et al. 2021

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Background: The present study aimed to determine the global prevalence of anosmia and dysgeusia in coronavirus disease 2019 (COVID-19) patients and to assess their association with severity and mortality of COVID-19. Moreover, this study aimed to discuss the possible pathobiological mechanisms of anosmia and dysgeusia in COVID-19. Methods: Available articles from PubMed, Scopus, Web of Science, and preprint databases (MedRxiv, BioRxiv, and Researchsquare) were searched on November 10th, 2020. Data on the characteristics of the study (anosmia, dysgeusia, and COVID-19) were extracted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Newcastle–Ottawa scale was used to assess research quality. Moreover, the pooled prevalence of anosmia and dysgeusia were calculated, and the association between anosmia and dysgeusia in presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was assessed using the Z test. Results: Out of 32,142 COVID-19 patients from 107 studies, anosmia was reported in 12,038 patients with a prevalence of 38.2% (95% CI: 36.5%, 47.2%); whereas, dysgeusia was reported in 11,337 patients out of 30,901 COVID-19 patients from 101 studies, with prevalence of 36.6% (95% CI: 35.2%, 45.2%), worldwide. Furthermore, the prevalence of anosmia was 10.2-fold higher (OR: 10.21; 95% CI: 6.53, 15.96, p < 0.001) and that of dysgeusia was 8.6-fold higher (OR: 8.61; 95% CI: 5.26, 14.11, p < 0.001) in COVID-19 patients compared to those with other respiratory infections or COVID-19 like illness. To date, no study has assessed the association of anosmia and dysgeusia with severity and mortality of COVID-19. Conclusion: Anosmia and dysgeusia are prevalent in COVID-19 patients compared to those with the other non-COVID-19 respiratory infections. Several possible mechanisms have been hypothesized; however, future studies are warranted to elucidate the definitive mechanisms of anosmia and dysgeusia in COVID-19. Protocol registration: PROSPERO CRD42020223204.

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Section: Resultsmentioning

confidence: 99%

Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis

et al. 2021

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“…De Sousa et al reported a 28-year-old male (SARS-CoV-2 IgM positive) presenting with intense headache, dysarthria and deviation of lip having MRI findings of cerebral vasculitis [ 112 ]. Bilateral trochlear nerve palsy due to cerebral vasculitis related to COVID-19 infection presenting with headache is also reported [ 113 ].…”

Section: Resultsmentioning

confidence: 99%

Rheumatological complications of Covid 19

Zacharias

Dubey

Koduri

et al. 2021

Autoimmunity Reviews

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Introduction COVID-19 has caused unprecedented hardships in the 21st century with more than 150 million infections. Various immunological phenomena have been described during the course of the infection, and this infection has also triggered autoimmunity. Rheumatological illnesses have been described following resolution of the acute infection; hence we sought to conduct a review of the rheumatological complications of COVID-19. Methods We conducted a literature search for articles relating to sequelae of COVID-19 from Jan 2020 to 30th April 2021. Results We found a number of reports of inflammatory arthritis after SARS-CoV-2 infection. SLE and renal disease have been described, and vasculitis also appears to be a common complication. Rhabdomyolysis and myositis has also been reported in a number of patients. We also found some evidence of large vessel vasculitis in ‘long COVID’ patients. Conclusions This review highlights a number of important complications such as inflammatory arthritis, lupus-like disease, myostis and vasculitis following SARS-CoV-2 infection.

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“…Cerebrovascular diseases 2 (28.6) (Xiong et al, 2020;Tiwari et al, 2021) 3 (13.6) (Asif and O' Mahony, 2020;Gulko et al, 2020;Dakay et al, 2021) 3 (15.8) (Cavalcanti et al, 2020;de Sousa et al, 2020;Dakay et al, 2021) 19 (31.7) (Al Saiegh et al, 2020;Cavalcanti et al, 2020;Cezar-Junior et al, 2020;Chia et al, 2020;Diaz-Segarra et al, 2020;Fara et al, 2020;Kantonen et al, 2020;Oxley et al, 2020;Pisano et al, 2020;Trifan et al, 2020a,b;Vu et al, 2020;Wang et al, 2020;Al-Mufti et al, 2021;Sabayan et al, 2021;Shah et al, 2021) 31 (43.1) (Agarwal et al, 2020;Anzalone et al, 2020;Cavalcanti et al, 2020;de Almeida Lima et al, 2020;Fabbri et al, 2021;Gupta et al, 2020;Heman-Ackah et al, 2020;Lapergue et al, 2020;Nicholson et al, 2020;Oxley et al, 2020;Patel et al, 2020;…”

Section: Age-associated Neurological Complications Of Covid-19unclassified

Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis

Sullivan

Fischer

2021

Front. Aging Neurosci.

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The outbreak of the novel and highly infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in hundreds of millions of infections and millions of deaths globally. Infected individuals that progress to coronavirus disease-19 (COVID-19) experience upper and lower respiratory complications that range in severity and may lead to wide-spread inflammation and generalized hypoxia or hypoxemia that impacts multiple organ systems, including the central and peripheral nervous systems. Since the SARS-CoV-2 outbreak, multiple reports continue to emerge that detail neurological symptoms, ranging from relatively mild (e.g., impaired taste and/or smell) to severe (e.g., stroke), suggesting SARS-CoV-2 may be neurotropic and/or contribute to nervous system injury through direct and/or indirect mechanisms. To gain insight into the types of neurological complications associated with SARS-CoV-2 infection and their possible relationship with age, sex, COVID-19 severity, and comorbidities, we performed a systematic review of case reports and series published in 2020 – April 4, 2021 of infected patients with neurological manifestations. Meta-analyses were conducted using individual patient data from reports where these data could be extracted. Here, we report neurological injury occurs across the lifespan in the context of infection, with and without known comorbidities, and with all disease severities, including asymptomatic patients. Older individuals, however, are more susceptible to developing life-threatening COVID-19 and cerebrovascular disease (CVD), such as stroke. A mild but inverse correlation with age was seen with CNS inflammatory diseases, such as encephalitis, as well as taste and/or smell disorders. When reported, increased age was also associated with comorbid cardiovascular risk factors, including hypertension, diabetes mellitus, and lipid disorders, but not with obesity. Obesity did correlate with development of critical COVID-19. Discussion into potential pathophysiological mechanisms by which neurological symptoms arise and long-term consequences of infection to the nervous system is also provided.

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Vasculitis-related stroke in young as a presenting feature of novel coronavirus disease (COVID19) – Case report

Cited by 9 publications

References 4 publications

Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis

Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis

Rheumatological complications of Covid 19

Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis

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