Vasculometabolic effects in patients with congenital growth hormone deficiency with and without GH replacement therapy during adulthood

Biscotto, Isabela Peixoto; Hong, Valéria; Batista, Rafael Loch; Mendonça, Berenice Bilharinho; Arnhold, Ivo Jorge Prado; Bortolotto, Luiz Aparecido; Carvalho, Luciani R.

doi:10.1007/s11102-020-01099-z

Cited by 6 publications

(2 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of a Brazilian kindred with congenital isolated GHD due to a homozygous mutation in the GH-releasing hormone (GHRH) receptor gene showed no serious deleterious effect of congenital isolated GHD on risks of vascular events and survival (114). However, this finding should not be extended to patients with hypopituitarism and AGHD, who present a distinct phenotype (115). Unfortunately, randomized clinical trials evaluating the effect of GH therapy on mortality in AGHD are unavailable.…”

Section: Gh Deficiency (Ghd) In Adultsmentioning

confidence: 99%

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

Garmes

Boguszewski

Miranda

et al. 2021

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.

show abstract

Section: Gh Deficiency (Ghd) In Adultsmentioning

confidence: 99%

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

Garmes

Boguszewski

Miranda

et al. 2021

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Although historical studies suggest cardio or cerebrovascular vascular damage in acquired GH deficiency (GHD) [ 12 , 13 ], more recent articles do not support this association, suggesting that vascular damage in acquired GHD may be linked to associated gonadal, thyroid, or cortisol deficits, their replacements and/or radiotherapy [ 14 , 15 ]. We have described a large cohort of individuals residing in Itabaianinha, in the Brazilian state of Sergipe, with severe short stature, but near normal ocular axial length [ 16 ], due to a congenital isolated GHD (IGHD), caused by the c.57 + 1G > A mutation in the GH releasing hormone receptor (GHRHR) gene ( GHRHR OMIM n.618157) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative measures of the vascular and neural components of the retina in adult individuals with congenital and untreated growth hormone deficiency

et al. 2022

View full text Add to dashboard Cite

Background The somatotrophic axis, including hypothalamic growth hormone (GH)-releasing hormone (GHRH), pituitary GH and circulating IGF-I, is critical for body size. However, the local production of GH/IGF-I (and IGF-II) and other peptides is relevant for other body functions, such as vascular, brain, and retinal function. The consequences of GH deficiency (GHD) on the retinal structure are still unclear, possibly reflecting the heterogeneity of patients and the different types of assessment in previous publications. Our purpose was to assess quantitative measures of the vascular and neural components of the retina in subjects with severe congenital isolated GHD (IGHD). Methods A cross-sectional study was carried out in 25 adult IGHD subjects and 25 age- and gender-matched controls. Interview, physical examination, laboratory data, optical coherence tomography (OCT) and OCT angiography (OCTA) were performed. Results OCT revealed no difference in the areas of the nerve fiber layer average, nor in the areas of superior, inferior, or nasal quadrants, between the two groups. However, areas of the temporal quadrant (p = 0.041), the optical disc (p = 0.042), the cup (p < 0.0001), as well as the cup/disc ratio (p < 0.0001), were higher in IGHD subjects than controls. The rim area was smaller (p = 0.002), although still normal. In OCTA, there was no difference in the minimum foveal thickness, central fovea, foveal avascular zone, and retinal density in any assessed area. Conclusions In conclusion, congenital IGHD does not affect quantitative measures of the vascular and neural retina, and it is associated with increased optical disc in this genetically homogeneous cohort.

show abstract

Special features on insulin resistance, metabolic syndrome and vascular complications in hypopituitary patients

Garmes

2024

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Vasculometabolic effects in patients with congenital growth hormone deficiency with and without GH replacement therapy during adulthood

Cited by 6 publications

References 68 publications

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

Quantitative measures of the vascular and neural components of the retina in adult individuals with congenital and untreated growth hormone deficiency

Special features on insulin resistance, metabolic syndrome and vascular complications in hypopituitary patients

Contact Info

Product

Resources

About