Vaskuläres Altern, Hypertonie und körperliche Aktivität

Schmidt‐Trucksäss, Arno; Weisser, B

doi:10.1055/s-0031-1292053

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Кроме того, увеличение физической активности было связано с более низким 5-летним прогрессированием СРПВ (на 0,16 м/с). По результатам исследования более активный образ жизни вели пациенты с супернормальным сосудистым старением, в то время как участники с преждевременным сосудистым старением более длительное время проводили в положении сидя, что согласуется с имеющимися данными о благоприятном влиянии физических упражнений на сосудистую стенку [29]. По результатам другого исследования авторы также продемонстрировали, что регулярные аэробные упражнения умеренной интенсивности, которые могут быть доступны большинству пациентов, способны снижать артериальную жесткость [30].…”

Section: материал и методыunclassified

Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants

Rotar

Бояринова

Tolkunova

et al. 2021

Cardiovasc Ther Prev

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Aim. To assess the association of cardiovascular risk factors with various vascular aging phenotypes using the St. Petersburg population sample as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study.Material and methods. The current analysis, performed within the ESSE-RF multicenter observational study, included 1600 St. Petersburg residents. The participants filled out a questionnaire to assess risk factors. In addition, blood biochemical parameters, anthropometric characteristics, and blood pressure were evaluated. Pulse wave velocity (PWV) was assessed by applanation tonometry using the SphygmoCor device (AtCor, Australia) in 524 people. For analysis, 485 participants without prior cardiovascular events were selected. PWV ≤10 percentile of PWV for healthy individuals in each age group was considered as the criterion for supernormal vascular aging (SUPERNOVA) phenotype, the PWV ≥90 percentile — early vascular aging (EVA), the PWV of 10-90 percentile — normal vascular aging (NVA).Results. The prevalence of SUPERNOVA phenotype was 9,7%, EVA — 18,8%, NVA — 71,5%. Patients with EVA phenotype were more likely to have HTN (60,4%) in comparison with those with SUPERNOVA phenotype (17%) and, less likely — high physical activity (39,6 vs 53,2%). Obesity, hyperglycemia, insulin resistance, hypercholesterolemia, dyslipoproteinemia, and excessive alcohol consumption were significantly less common in participants with SUPERNOVA phenotype compared with those with EVA phenotype.Conclusion. In addition to HTN and dyslipoproteinemia, a significant predictor of premature aging was the cumulative effect of obesity, insulin resistance and hypertriglyceridemia. Among behavioral risk factors, higher physical activity and adequate alcohol consumption were factors associated with supernormal aging.

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Section: материал и методыunclassified

Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants

Rotar

Бояринова

Tolkunova

et al. 2021

Cardiovasc Ther Prev

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“… 20 Regular aerobic physical activity of moderate intensity has been shown in adults to be associated with lower arterial stiffness and lower carotid intima-media thickness (IMT). 21 22 In contrast, in sedentary healthy adults, ageing is associated with increased stiffness of the large elastic arteries and with poorer vascular endothelial function and increased mortality. 22 23 The EVIDENT study found an association of physical activity with better vascular structure and function and sedentary time (hours spent watching television) with greater arterial stiffness.…”

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confidence: 99%

Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study

et al. 2016

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IntroductionThe process of population ageing that is occurring in developed societies represents a major challenge for the health system. The aim of this study is to analyse factors that have an influence on early vascular ageing (EVA), estimated by carotid-femoral pulse wave velocity (cf-PWV) and Cardio Ankle Vascular Index (CAVI), and to determine differences by gender in a Spanish population.Methods and analysisAn observational, descriptive, cross-sectional study.Study populationFrom the population assigned to the participating healthcare centres, a cluster random sampling stratified by age and gender will be performed to obtain 500 participants aged between 35 and 75. Those who meet the inclusion criteria and give written informed consent will be included in the study.MeasurementsMain dependent variables: cf-PWV determined using the SphygmoCor System and CAVI estimated using VASERA. Secondary dependent variables: telomere length, carotid intima-media thickness, central and peripheral augmentation index, ankle-brachial pulse wave velocity, ankle-brachial index, retinal arteriovenous index, and renal and cardiac organ damage. Independent variables: lifestyles (physical activity, adherence to the Mediterranean diet, alcohol and tobacco consumption); psychological factors (depression, anxiety and chronic stress); inflammatory factors and oxidative stress.Ethics and disseminationThe study has been approved by the clinical research ethics committee of the healthcare area of Salamanca. All study participants will sign an informed consent form agreeing to participate in the study in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow the understanding of the relationship of the different influencing factors and their relative weight in the development of EVA. At least 5 publications in first-quartile scientific journals are planned.Trial registration numberNCT02623894; Pre-results.

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Marathon run: cardiovascular adaptation and cardiovascular risk

Predel¹

2014

European Heart Journal

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The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the main motives for these amateur marathon runners is the expectation that endurance exercise (EE) delivers profound beneficial health effects. However, with respect to the cardiovascular system, a controversial debate has emerged whether the marathon run itself is healthy or potentially harmful to the cardiovascular system, especially in middle-aged non-elite male amateur runners. In this cohort, exercise-induced increases in cardiac biomarkers-troponin and brain natriuretic peptide-and acute functional cardiac alterations have been observed and interpreted as potential cardiac damage. Furthermore, in the cohort of 40- to 65-year-old males engaged in intensive EE, a significant risk for the development of atrial fibrillation has been identified. Fortunately, recent studies demonstrated a normalization of the cardiac biomarkers and the functional alterations within a short time frame. Therefore, these alterations may be perceived as physiological myocardial reactions to the strenuous exercise and the term 'cardiac fatigue' has been coined. This interpretation is supported by a recent analysis of 10.9 million marathon runners demonstrating that there was no significantly increased overall risk of cardiac arrest during long-distance running races. In conclusion, intensive and long-lasting EE, e.g. running a full-distance Marathon, results in high cardiovascular strain whose clinical relevance especially for middle-aged and older athletes is unclear and remains a matter of controversy. Furthermore, there is a need for evidence-based recommendations with respect to medical screening and training strategies especially in male amateur runners over the age of 35 years engaged in regular and intensive EE.

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Vaskuläres Altern, Hypertonie und körperliche Aktivität

Cited by 3 publications

References 33 publications

Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants

Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants

Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study

Marathon run: cardiovascular adaptation and cardiovascular risk

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