Vasoactive Intestinal Peptide and Nerve Regeneration

Rayan, Ghazi M.; Said, Sami I.; Cahill, S.L.; Duke, James C.

doi:10.1016/0266-7681(91)90106-x

Cited by 17 publications

(23 citation statements)

References 15 publications

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“…For example, these factors affect neurotransmitter release and survival of hippocampal neurons as well as controlling cerebellar maturation (Arimura, 1998;Basille et al, 1993;Bluet-Pajot et al, 1998;Otto et al, 2001;Rayan et al, 1991;Vaudry et al, 2002;Zhou et al, 2002). These PACAP and VIP functions are mediated by three PACAP receptors, PAC1, VPAC1, and VPAC2 (Christophe, 1993;Muller et al, 1995;Tatsuno et al, 1994;Zhou et al, 2002).…”

Section: Introductionmentioning

confidence: 95%

PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells

Nishimoto

Furuta

Aoki

et al. 2006

Glia

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The Pituitary adenylate cyclase-activating peptide (PACAP) ligand/type 1 receptor (PAC1) system regulates neurogenesis and gliogenesis. It has been well established that the PACAP/PAC1 system induces differentiation of neural progenitor cells (NPCs) through the Gs-mediated cAMP-dependent signaling pathway. However, it is unknown whether this ligand/receptor system has a function in proliferation of NPCs. In this study, we identified that PACAP and PAC1 were highly expressed and co-localized in NPCs of mouse cortex at embryonic day 14.5 (E14.5) and found that the PACAP/PAC1 system potentiated growth factor-induced proliferation of mouse cortical NPCs at E14.5 via Gq-, but not Gs-, mediated PLC/IP3-dependent signaling pathway in an autocrine manner. Moreover, PAC1 activation induced elongation of cellular processes and a stellate morphology in astrocytes that had the bromodeoxyuridine (BrdU)-incorporating ability of NPCs. Consistent with this notion, we determined that the most BrdU positive NPCs differentiated to astrocytes through PAC1 signaling. These results suggest that the PACAP/PAC1 system may play a dual role in neural/glial progenitor cells not only differentiation but also proliferation in the cortical astrocyte lineage via Ca2+-dependent signaling pathways through PAC1.

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Section: Introductionmentioning

confidence: 95%

PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells

Nishimoto

Furuta

Aoki

et al. 2006

Glia

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“…VIP has been shown to act as a growth factor for proliferation of keratinocytes and as a modulator of their migration (61) as well as inducing histamine release by mast cells causing vasodilatation (62). VIP may be involved in the re-innervation of wounded tissue as it has been shown to promote sciatic nerve regeneration in rat sciatic nerve after transection (63). PACAP is found in sensory cutaneous nerves (64).…”

Section: Proliferative Phasementioning

confidence: 99%

The Role of Neuromediators and Innervation in Cutaneous Wound Healing

Ashrafi¹,

Baguneid²,

Bayat³

2016

Acta Derm Venerol

101

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The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the overlapping stages of cutaneous wound healing. Numerous neuropeptides that are secreted by the sensory and autonomic nerve fibres play an essential part during the distinct phases of wound healing. Delayed wound healing in diabetes and fetal cutaneous regeneration following wounding further highlights the pivotal role skin innervation and its associated neuromediators play in wound healing. Understanding the mechanisms via which cutaneous innervation modulates wound healing in both the adult and fetus will provide opportunities to develop therapeutic devices which could manipulate skin innervation to aid wound healing.

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“…The amino acid sequence of GIP (Tseng et al, 1993) substantiates the idea that this polypeptide is member of a structurally related family of hormones including secretin, glucagon, glucagon-like peptides 1 and 2 (GLP-1, GLP-2), vasoactive intestinal peptide (VIP), growth hormone-releasing factor (GHRF), and pituitary adenylyl cyclase-activating polypeptide (PACAP). Interestingly, recent studies described important roles of these intestinal peptides, e.g., in nerve development, regeneration, and/or neuronal survival (Rayan et al, 1995;Waschek, 1995;Klimaschewski, 1997;Lioudyno et al, 1998;Zhang et al, 2002;Martin et al, 2005;Pavelock et al, 2007).…”

mentioning

confidence: 99%

Glucose‐dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): Cellular localization, lesion‐affected expression, and impaired regenerative axonal growth

Buhren

Gasis

Thorens

et al. 2009

J of Neuroscience Research

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Glucose-dependent insulinotropic polypeptide (GIP) was initially described to be rapidly regulated by endocrine cells in response to nutrient ingestion, with stimulatory effects on insulin synthesis and release. Previously, we demonstrated a significant up-regulation of GIP mRNA in the rat subiculum after fornix injury. To gain more insight into the lesion-induced expression of GIP and its receptor (GIPR), expression profiles of the mRNAs were studied after rat sciatic nerve crush injury in 1) affected lumbar dorsal root ganglia (DRG), 2) spinal cord segments, and 3) proximal and distal nerve fragments by means of quantitative RT-PCR. Our results clearly identified lesion-induced as well as tissue type-specific mRNA regulation of GIP and its receptor. Furthermore, comprehensive immunohistochemical stainings not only confirmed and exceeded the previous observation of neuronal GIP expression but also revealed corresponding GIPR expression, implying putative modulatory functions of GIP/GIPR signaling in adult neurons. In complement, we also observed expression of GIP and its receptor in myelinating Schwann cells and oligodendrocytes. Polarized localization of GIPR in the abaxonal Schwann cell membranes, plasma membrane-associated GIPR expression of satellite cells, and ependymal GIPR expression strongly suggests complex cell type-specific functions of GIP and GIPR in the adult nervous system that are presumably mediated by autocrine and paracrine interactions, respectively. Notably, in vivo analyses with GIPR-deficient mice suggest a critical role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush, insofar as traumatic injury of GIPR-deficient mouse sciatic nerve revealed impaired axonal regeneration compared with wild-type mice.

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Vasoactive Intestinal Peptide and Nerve Regeneration

Cited by 17 publications

References 15 publications

PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells

PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells

The Role of Neuromediators and Innervation in Cutaneous Wound Healing

Glucose‐dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): Cellular localization, lesion‐affected expression, and impaired regenerative axonal growth

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