Vasoactive intestinal peptide inhibits degranulation and changes granular content of mast cells: a potential therapeutic strategy in controlling septic shock

Tunçel, Neşe; Töre, Fatma; Şahıntürk, Varol; Ak, Dilek; Tunçel, Muzaffer

doi:10.1016/s0196-9781(99)00177-1

Cited by 48 publications

(46 citation statements)

References 48 publications

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“…Treatment with VIP, PACAP, UCN, AM, CST or GHR delays the onset, increases survival and reduces the severity of various experimental models of sepsis [34,35,36,37,38], collagen-induced arthritis [39,40,41,42], inflammatory bowel disease [43,44,45,46], multiple sclerosis [47,48,49], type I diabetes mellitus [50], Sjögren’s syndrome [51], pancreatitis [52,53] and uveoretinitis [54,55] (table 1). The therapeutic effect of these neuropeptides is associated with the reduction of the two main phases of these diseases.…”

Section: Endogenous Anti-inflammatory Neuropeptides With An Immunomodmentioning

confidence: 99%

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Neuropeptides as Pleiotropic Modulators of the Immune Response

et al. 2011

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Although necessary to eliminate pathogens, inflammation can lead to serious deleterious effects in the host if left unchecked. During the inflammatory response, further damage may arise from potential autoimmune responses occurring when the immune cells and molecules that respond to pathogen-derived antigens also react to self-antigens. In this sense, the identification of endogenous factors that control exacerbated immune responses is a key goal for the development of new therapeutic approaches for inflammatory and autoimmune diseases. Some neuropeptides that are produced during the ongoing inflammatory response have emerged as endogenous anti-inflammatory agents that could collaborate in tuning the balanced steady state of the immune system. These neuropeptides participate in maintaining immune tolerance through two distinct mechanisms: by regulating the balance between pro-inflammatory and anti-inflammatory factors, and by inducing the emergence of regulatory T cells with suppressive activity against autoreactive T cell effectors. Indeed, a functioning neuropeptide system contributes to general health, and alterations in the levels of these neuropeptides and/or their receptors lead to changes in susceptibility to inflammatory and autoimmune diseases. Recently, we found that some neuropeptides also have antimicrobial and antiparasitic actions, suggesting that they could act as primary mediators of innate defense, even in the most primitive organisms. In this review, we use the vasoactive intestinal peptide as example of an immunomodulatory neuropeptide to summarize the most relevant data found for other neuropeptides with similar characteristics, including adrenomedullin, urocortin, cortistatin and ghrelin.

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Section: Endogenous Anti-inflammatory Neuropeptides With An Immunomodmentioning

confidence: 99%

“…Neuropeptides also modulate inflammatory responses through the regulation of different functions of mast cells, such as degranulation [38,67,68,69]. …”

Section: Endogenous Anti-inflammatory Neuropeptides With An Immunomodmentioning

confidence: 99%

Neuropeptides as Pleiotropic Modulators of the Immune Response

et al. 2011

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“…Recently, from the large number of soluble inflammatory mediators and different cellular effector populations implicated in the onset of arthritis, mast cells have been proven to be the cellular link between soluble factors and inflammatory arthritis (Lee et al, 2002). In general, VIP and PACAP cause histamine release from mast cells (Lowman et al, 1988;Benyon et al, 1989;Mousli et al, 1994;Ottosson and Edvinsson, 1997;Odum et al, 1998), but other effects have been also reported (Tuncel et al, 2000), probably reflecting the functional heterogeneity of mast cells.…”

Section: B Biochemical Pharmacological and Signaling Key Features mentioning

confidence: 99%

“…Furthermore, additional mechanisms could be participating in the therapeutic effect of VIP on endotoxemia. Indeed, other studies (Tuncel and Tore, 1998;Tuncel et al, 2000) suggested that the protective effect of VIP on septic shock syndrome is mediated through the regulation of serum levels of hormones, such as adrenaline and cortisol, which control hemodynamic constants, important events in the pathology of sepsis.…”

Section: A Septic Shockmentioning

confidence: 99%

The Significance of Vasoactive Intestinal Peptide in Immunomodulation

Delgado

Pozo²,

Ganea³

2004

Pharmacol Rev

372

319

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“…Both reside in the gastrointestinal tract and central nervous system. Also, SP [6] and VIP [7] are interactive signaling molecules between the nervous system and the immune system. SP and VIP could regulate the function of intestinal mucosal mast cells by regulating neurosecretion and paracrine secretion.…”

Section: Introductionmentioning

confidence: 99%

Regulatory Mechanism of Electroacupuncture in Irritable Bowel Syndrome: Preventing MC Activation and Decreasing SP VIP Secretion

Jiang

Zhou

et al. 2007

Dig Dis Sci

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The efficacy of electroacupuncture (EA) for treating patients with diarrhea-predominant IBS has been confirmed in the authors' former research, but the regulatory mechanism of EA in IBS is still unknown. The aim of this study was to explore the relationship between the effect of EA on treating IBS rats and the activation and proliferation of mast cell (MC), the secretion of substance P(SP), and vasoactive intestinal polypeptide (VIP). The IBS rat model was set up with stress of binding limbs and colorectal distention. All rats were randomly assigned to four groups (Normal, Model, Tegaserod and EA). Hematoxylin and eosin staining has been used to observe the pathological change in the rats' colonic mucosa and an AWR scoring system has been applied to evaluate improvement of visceral hypersensitivity in various methods of the different groups. Toluidine blue improved method (TBI) and immunohistochemistry have also been involved in observations of mucous mast cells in the colon, change of c-fos positive cells, and secretion of SP, SPR, VIP, VIPR in the local colon. Firstly, the threshold of visceral sensitivity in the rats model with IBS was remarkably reduced (P < 0.01). The MC count in colonic mucosa and c-fos positive cells count increased significantly (P < 0.01) with positive correlation within each. Secondly, EA on ST-25 and Tegaserod pouring into the stomach can inhibit the proliferation and activation of MC in the colon and regulate secretion of SP, SPR, VIP, VIPR (P < 0.01, P < 0.05), while the effect of EA is obviously superior to Tegaserod. We concluded, firstly, that the abnormal proliferation and activation of mucous mast cells in the colon, and oversecretion of neuropeptides such as SP, VIP and their receptors could be one of key mechanisms of etiology of IBS. Secondly, the inhibition of activation and proliferation and the secretion of SP, VIP could be major effects of EA when treating rats with IBS.

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Vasoactive intestinal peptide inhibits degranulation and changes granular content of mast cells: a potential therapeutic strategy in controlling septic shock

Cited by 48 publications

References 48 publications

Neuropeptides as Pleiotropic Modulators of the Immune Response

Neuropeptides as Pleiotropic Modulators of the Immune Response

The Significance of Vasoactive Intestinal Peptide in Immunomodulation

Regulatory Mechanism of Electroacupuncture in Irritable Bowel Syndrome: Preventing MC Activation and Decreasing SP VIP Secretion

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