Vasoactive intestinal peptide inhibits liver pathology in acute murine schistosomiasis mansoni and modulates IL-10, IL-12 and TNF-α production

Allam, Gamal

doi:10.1016/j.imbio.2007.05.006

Cited by 13 publications

(14 citation statements)

References 78 publications

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“…In consistent with several studies, the present study showed that the inflammatory reactions induced in livers of S. mansoni infected mice are ensured by marked increase in serum GGT and ALT levels and a decrease in albumin level [29,55]. The increase of such enzymes in serum may be due to the destruction of hepatocytes by the action of toxins of the parasite eggs leading to their release into the circulation [56].…”

Section: Discussionsupporting

confidence: 88%

Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice

Farrag¹

2015

AJLS

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Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin-10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.

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Section: Discussionsupporting

confidence: 88%

Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice

Farrag¹

2015

AJLS

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“…This depletion in liver enzymes activities could be due to leakage of these enzymes from necrotic tissue and the replacement of normal liver tissue by granulomatous lesions and fibrosis (Allam and Ahmed, 2005;Allam, 2007). However, infected mice treated with curcumin restore the hepatic ALT, AST, g-GT, and LDH activities that it was decreased by S. mansoni infection.…”

Section: Article In Pressmentioning

confidence: 99%

Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni

Allam¹

2009

Immunobiology

136

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“…The production of IL-10 during this latter period seems to have an important role in hepatic granuloma formation and in the regulation of CD4 + T cell responses in schistosomiasis, as well as in the transition from acute to chronic disease state [ 17 , 23 – 25 ]. In the mouse model, both Th1 and Th2 cytokines can orchestrate granuloma development [ 16 , 25 , 26 ]. Th2–type responses are typically characterized by increases in the levels of interleukin-4 (IL-4) and other cytokines (including IL-5, IL-6, IL-9, and IL-13), activation and expansion of CD4 + Th2 cells, plasma cells secreting IgE, eosinophils, mast cells and basophils [ 16 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel

et al. 2015

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BackgroundSchistosomiasis is the third most devastating tropical disease worldwide caused by blood flukes of the genus Schistosoma. This parasitic disease is due to immunologic reactions to Schistosoma eggs trapped in tissues. Egg-released antigens stimulate tissue-destructive inflammatory and granulomatous reactions, involving different immune cell populations, including T cells and granulocytes. Granulomas lead to collagen fibers deposition and fibrosis, resulting in organ damage. Praziquantel (PZQ) is the drug of choice for treating all species of schistosomes. However, PZQ kills only adult Schistosoma worms, not immature stages. The inability of PZQ to abort early infection or prevent re-infection, and the lack of prophylactic effect prompt the need for novel drugs and strategies for the prevention of schistosomiasis.Methodology/Principal FindingsUsing in vitro and in vivo approaches, we have found that the alkylphospholipid analog edelfosine kills schistosomula, and displays anti-inflammatory activity. The combined treatment of PZQ and edelfosine during a few days before and after cercariae infection in a schistosomiasis mouse model, simulating a prophylactic treatment, led to seven major effects: a) killing of Schistosoma parasites at early and late development stages; b) reduction of hepatomegaly; c) granuloma size reduction; d) down-regulation of Th1, Th2 and Th17 responses at late post-infection times, thus inhibiting granuloma formation; e) upregulation of IL-10 at early post-infection times, thus potentiating anti-inflammatory actions; f) down-regulation of IL-10 at late post-infection times, thus favoring resistance to re-infection; g) reduction in the number of blood granulocytes in late post-infection times as compared to infected untreated animals.Conclusions/SignificanceTaken together, these data suggest that the combined treatment of PZQ and edelfosine promotes a high decrease in granuloma formation, as well as in the cellular immune response that underlies granuloma development, with changes in the cytokine patterns, and may provide a promising and effective strategy for a prophylactic treatment of schistosomiasis.

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Vasoactive intestinal peptide inhibits liver pathology in acute murine schistosomiasis mansoni and modulates IL-10, IL-12 and TNF-α production

Cited by 13 publications

References 78 publications

Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice

Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice

Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni

Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel

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