Vasoactive Intestinal Peptide Promotes Immune Escape of MKN45 Cells by Inhibiting Antigen-Presenting Molecules of Dendritic Cells In Vitro

Zhou, Xijin; Wu, Fang; Jiang, Lili; Huang, Lifang; Li, Guohua

doi:10.1007/s10989-016-9513-0

Cited by 1 publication

(1 citation statement)

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“…The invariant chain (Ii chain) also known as CD74 is type Ⅱ transmembrane glycoprotein. The Ii chain associated with MHC Ⅱ a chains and b chains could be involved in immune escape by inhibiting the expression of MHC Ⅱ molecule and endogenous antigens (Zhou et al., 2016). LIGHT (lymphotoxin‐related inducible ligand that competes with herpes simplex virus glycoprotein D for herpesvirus entry mediator on T cells) is a member of the tumour necrosis factor ligand superfamily, which plays important roles in inflammatory and immune responses (Li et al., 2013).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of turbot (Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection

Song

Dong

2022

Journal of Fish Diseases

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The diseases triggered by Vibrio anguillarum infection have created huge economic losses to the turbot (Scophthalmus maximus) farming industry. However, the immune mechanism of turbot to V. anguillarum infection has not been deeply investigated. To better understand the immune response of turbot to V. anguillarum infection, transcriptome analysis of the head kidney and liver of turbot was performed. A total of 15,948 and 11,494 differentially expressed genes (DEGs) were obtained from the turbot head kidney and liver, respectively. Transcriptome analysis revealed that the head kidney and liver of turbot have some differences in the gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the DEGs for the different functions of these two organs. Although there are many uncertain factors in this immune process, such as the occurrence of alternative splicing (AS) events and the differences in the protein structure of the DEGs, the NFκB signalling pathway, MKK‐dependent AP‐1 activation, JAK‐STAT signalling pathway, the signal transmission of MHC Ⅰ and a series of DEGs including HSP90 driving NLRP3 to produce inflammatory factors (IL‐1β, IL‐8, TNFα, etc.) were possible important immune response pathways for turbot to V. anguillarum infection. Overall, our research has conducted a preliminary exploration of the immune mechanism of turbot in response to V. anguillarum infection.

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Section: Discussionmentioning

confidence: 99%