Vasoactive mediators and retinopathy during type 1 diabetic pregnancy

Loukovaara, Sirpa; Immonen, Ilkka; Yandle, Tim G.; Nicholls, Gary; Hiilesmaa, Vilho; Kaaja, Risto

doi:10.1111/j.1600-0420.2005.00384.x

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…also found that AM levels were not changed in the maternal circulation, but found higher AM levels in the amniotic fluid of pregnant diabetic women [54]. Plasma AM was found to be unchanged in pregnant women with type I diabetes mellitus (T1DM) [55], and in a subsequent study AM was found to be unchanged in the plasma of women with gestational diabetes [56]. These data suggest that circulating AM may not be altered in pregnant women with gestational diabetes, but fetal or placental AM production may be elevated, potentially resulting in the observed increased amniotic fluid AM concentration.…”

Section: Adrenomedullin In Pregnancy Complicationsmentioning

confidence: 99%

Adrenomedullin and pregnancy: perspectives from animal models to humans

Lenhart¹,

Caron²

2012

Trends in Endocrinology & Metabolism

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A healthy pregnancy requires strict coordination of genetic, physiologic, and environmental factors. The relatively common incidence of infertility and pregnancy complications has resulted in increased interest in understanding the mechanisms that underlie normal versus abnormal pregnancy. The peptide hormone adrenomedullin has recently been the focus of some exciting breakthroughs in the pregnancy field. Supported by mechanistic studies in genetic animal models, there continues to be a growing body of evidence demonstrating the importance of adrenomedullin protein levels in a variety of human pregnancy complications. With more extensive mechanistic studies and improved consistency in clinical measurements of adrenomedullin, there is great potential for the development of adrenomedullin as a clinically-relevant biomarker in pregnancy and pregnancy complications.

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Section: Adrenomedullin In Pregnancy Complicationsmentioning

confidence: 99%

Adrenomedullin and pregnancy: perspectives from animal models to humans

Lenhart¹,

Caron²

2012

Trends in Endocrinology & Metabolism

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“…Therefore, markers of the renin-angiotensin system (RAS) plasma renin activity (PRA), angiotensin II (AngII), aldosterone, natriuretic peptides (ANP, BNP, CNP) and adrenomedullin (AM) were measured during pregnancy and postpartum [128]. The women with diabetes were grouped according to progression of retinopathy during pregnancy and postpartum.…”

Section: Hypervolaemia and Hyperperfusionmentioning

confidence: 99%

Progression of Retinopathy in Type 1 Diabetic Women During Pregnancy

Kaaja¹,

Loukovaara

2007

CDR

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Progression of diabetic retinopathy (DR) occurs at least temporarily during pregnancy and postpartum. The pathogenetic mechanisms of DR progression during pregnancy are not fully understood. Several factors related to metabolic changes (hyperglycaemia), diabetes itself (duration of diabetes before conception, baseline status of DR), pregnancy physiology (hypervolaemia and hypercoagulation, impaired retinal autoregulation) and pregnancy complications (pre-eclampsia) seem to play important roles in the progression of DR during pregnancy. On the other hand, systemic angiopoietic and vasoactive factors seem to have minor role in the deterioration of DR during that time period. Good glycaemic control, normotension, lack of nephropathy as well as lack of pre-proliferative/proliferative changes of DR are good prognostic factors as regards the progression of DR during pregnancy. However, pregnancy seems to have no long-term detrimental effects as regards the progression of DR unless it has proceeded to pre-proliferative and proliferative phases.

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“…Di Iorio et al also found that ADM levels were not changed in the maternal circulation, but found higher ADM levels in the amniotic fluid of pregnant diabetic women (Di Iorio et al, 2001). Plasma ADM was found to be unchanged in pregnant women with type I diabetes mellitus (T1DM) (Loukovaara et al, 2005), and in a subsequent study ADM was found to be unchanged in the plasma of women with gestational diabetes (Pöyhönen-Alho et al, 2010). These data suggest that circulating ADM may not be altered in pregnant women with gestational diabetes, but fetal or placental ADM production may be elevated, potentially resulting in the observed increased amniotic fluid ADM concentration.…”

Section: Adm In Gestational Diabetesmentioning

confidence: 86%

Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses

Paudel

Liu

Cummings

et al. 2021

Biology of Reproduction

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Adrenomedullin (ADM) is an evolutionarily conserved multi-functional peptide hormone that regulates implantation, embryo spacing and placentation in humans and rodents. However, the potential roles of ADM in implantation and placentation in pigs, as a litter-bearing species, are not known. This study determined abundances of ADM in uterine luminal fluid, and the patterns of expression of ADM and its receptor components (CALCRL, RAMP2, RAMP3, and ACKR3) in uteri from cyclic and pregnant gilts, as well as conceptuses (embryonic/fetus and its extra-embryonic membranes) during the peri-implantation period of pregnancy. Total recoverable ADM was greater in the uterine fluid of pregnant compared with cyclic gilts between Days 10 and 16 post-estrus, and was from uterine luminal epithelial (LE) and conceptus trophectoderm (Tr) cells. Uterine expression of CALCRL, RAMP2, and ACKR3 were affected by day (P < 0.05), pregnant status (P < 0.01) and/or day x status (P < 0.05). Within porcine conceptuses, expression of CALCRL, RAMP2 and ACKR3 increased between Days 10 and 16 of pregnancy. Using an established porcine trophectoderm (pTr1) cell line, it was determined that 10−7 M ADM stimulated proliferation of pTr1 cells (P < 0.05) at 48 h, and increased phosphorylated mechanistic target of rapamycin (p-MTOR) and 4E binding protein 1 (p-4EBP1) by 6.1- and 4.9-fold (P < 0.0001), respectively. These novel results indicate a significant role for ADM in uterine receptivity for implantation and conceptus growth and development in pigs. They also provide a framework for future studies of ADM signaling to affect proliferation and migration of Tr cells, spacing of blastocysts, implantation and placentation in pigs.

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Vasoactive mediators and retinopathy during type 1 diabetic pregnancy

Cited by 10 publications

References 42 publications

Adrenomedullin and pregnancy: perspectives from animal models to humans

Adrenomedullin and pregnancy: perspectives from animal models to humans

Progression of Retinopathy in Type 1 Diabetic Women During Pregnancy

Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses

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