Vasoactive peptides in experimental renal hypertension

Johnston, Colin I.; Pullan, P. T.; Walter, Noel

doi:10.1007/bf01477457

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Since the early development of renal hypertension is generally believed to be mediated by increased activity of the renin-angiotensin system (liard et al, 1974;Mohring et al, 1975;Carretero and Romero, 1977;Davis, 1977;Johnston et al, 1978), a vasoconstrictor component associated with high circulating levels of angiotension II is one likely candidate for producing the similarity in the overall time waveform of the hindquarters resistance response in protected and unprotected hindquarters. There is also evidence to suggest that sympathetic activity is inappropriately elevated during renal hypertension (Ferrario and McCubbin, 1974;.…”

Section: Possible Mechanisms and Implicationsmentioning

confidence: 99%

Hemodynamic and microvascular responses in the hindquarters during the development of renal hypertension in rats. Evidence for the involvement of an autoregulatory component.

Meininger¹,

Lubrano²,

Granger³

1984

Circulation Research

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SUMMARY. Microvascular responses in the cremaster muscle were compared with changes in mean arterial pressure and hindquarters vascular resistance during the development (initial 3 hours) of two-kidney one-clip renal hypertension in rats, to examine the possibility that an autoregulatory mechanism may contribute to the development of hypertension. Rats were anesthetized with urethane and chloralose and implanted with Doppler flow probes on the renal artery and abdominal aorta. Acute hypertension was produced by inflation of a balloon occluder on the renal artery to reduce renal flow by 50%. The cremaster muscle was isolated with intact innervation and circulation for measurement of microvessel diameters. To determine whether increased pressure contributed to the changes in hindquarters vascular resistance or in microvascular diameters during acute hypertension, arterial pressure was prevented from increasing in the hindquarters region after renal artery stenosis by servo-controlled inflation of a balloon occluder around the sacral aorta to maintain hindquarters pressure at normotensive levels. In hypertensive rats with unprotected hindquarters, mean arterial pressure and hindquarters vascular resistance increased 26% and 20%, respectively, after renal artery stenosis. In comparison, hypertensive rats with protected hindquarters exhibited a similar increase in mean arterial pressure, but hindquarters vascular resistance was significantly reduced compared to that in hypertensive rats with unprotected hindquarters. In the cremaster microcirculation, vasoconstriction was observed only in the small third-(mean ± SEM: 29 ± 4 ^m) and fourth-(12 ± 2 fim) order arterioles in rats with unprotected hindquarters. In general, microvessel diameters in rats with protected hindquarters that had lower hindquarters vascular resistance than those with unprotected hindquarters were larger for the second-(82 ± 5 ^m), third-, and fourth-order arterioles, suggesting less vasoconstrictor tone. Our data indicate that the increase in hindquarters resistance during the development of renal hypertension is, in part, dependent on the presence of a pressure-dependent autoregulatory process. (Circ Res 55: 609-622, 1984)

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Section: Possible Mechanisms and Implicationsmentioning

confidence: 99%

Hemodynamic and microvascular responses in the hindquarters during the development of renal hypertension in rats. Evidence for the involvement of an autoregulatory component.

Meininger¹,

Lubrano²,

Granger³

1984

Circulation Research

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show abstract

“…Several studies have demonstrated elevation of plasma AVP in the benign phase of DOC-salt hyperten sion [39], Elevated plasma AVP levels have been re ported in benign renovascular hypertension in rats [39,40] and in dogs [41], spontaneously hypertensive rats (SHR) [39. 42] and in stroke-prone SHR [43].…”

Section: Is Plasma Vasopressin Elevated In Hypertension?mentioning

confidence: 99%