Vasoactive properties of antihypertensive lactoferrin-derived peptides in resistance vessels: Effects in small mesenteric arteries from SHR rats

García-Tejedor, Aurora; Manzanares, Paloma; Castelló-Ruiz, María; Moscardó, Antonio; Marcos, José F.; Salom, Juan B.

doi:10.1016/j.lfs.2017.07.036

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…Based on this timeline, the natural course of the SHR model can be divided into the following categories: prehypertensive (Ͻ6 wk of age), developing hypertension (7-12 wk of age), and established hypertension (Ͼ12 wk old) (71,639). The characteristics of this model resemble essential hypertension in humans, and the SHR model has been extensively used in studies involving stroke (9,256,621), myocardial hypertrophy (319,390), changes in vascular resistances (45,184,728), and hypertension and sex hormones (425,426,751,753), among many others.…”

Section: Spontaneously Hypertensive Ratmentioning

confidence: 99%

Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

Gonzalez‐Vicente

Sáez

Monzón

et al. 2019

Physiological Reviews

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The thick ascending limb plays a key role in maintaining water and electrolyte balance. The importance of this segment in regulating blood pressure is evidenced by the effect of loop diuretics or local genetic defects on this parameter. Hormones and factors produced by thick ascending limbs have both autocrine and paracrine effects, which can extend prohypertensive signaling to other structures of the nephron. In this review, we discuss the role of the thick ascending limb in the development of hypertension, not as a sole participant, but one that works within the rich biological context of the renal medulla. We first provide an overview of the basic physiology of the segment and the anatomical considerations necessary to understand its relationship with other renal structures. We explore the physiopathological changes in thick ascending limbs occurring in both genetic and induced animal models of hypertension. We then discuss the racial differences and genetic defects that affect blood pressure in humans through changes in thick ascending limb transport rates. Throughout the text, we scrutinize methodologies and discuss the limitations of research techniques that, when overlooked, can lead investigators to make erroneous conclusions. Thus, in addition to advancing an understanding of the basic mechanisms of physiology, the ultimate goal of this work is to understand our research tools, to make better use of them, and to contextualize research data. Future advances in renal hypertension research will require not only collection of new experimental data, but also integration of our current knowledge.

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Section: Spontaneously Hypertensive Ratmentioning

confidence: 99%

Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

Gonzalez‐Vicente

Sáez

Monzón

et al. 2019

Physiological Reviews

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“…This indicates that the high‐dose SPH‐T treatment could enhance endothelial NO‐dependent vasodilation without triggering a direct vasodilatory effect. Previous studies involving NO‐dependent vasodilatory mechanisms often contributed to direct changes in vasodilation, whereas our study provided a new mechanism of antihypertensive peptides on vascular function (García‐Tejedor et al., 2017; Jahandideh et al., 2016; Majumder et al., 2013; Miguel et al., 2007). Despite an insignificant improvement in vasodilation in young SHRs, it may be interesting to test SPH‐T in aged animals, which show a progressive decline of NO production and bioavailability (Cau et al., 2012; Smith et al., 2006).…”

Section: Resultsmentioning

confidence: 59%

“…This indicates that the high-dose SPH-T treatment could enhance endothelial NO-dependent vasodilation without triggering a direct vasodilatory effect. Previous studies involving NO-dependent vasodilatory mechanisms often contributed to direct changes in vasodilation, whereas our study provided a new mechanism of antihypertensive peptides on vascular function (García-Tejedor et al, 2017;Jahandideh et al, 2016; ) on nitrotyrosine level in aorta. The expression of nitrotyrosine was normalized to that of GAPDH.…”

Section: Discussionmentioning

confidence: 61%

Chicken muscle hydrolysate reduces blood pressure in spontaneously hypertensive rats, upregulates ACE2, and ameliorates vascular inflammation, fibrosis, and oxidative stress

Fan

Liao

Spaans

et al. 2022

Journal of Food Science

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Spent hens are egg‐laying chicken reaching the end of their egg‐laying cycle and are seen as a by‐product to the egg industry. A spent hen muscle protein hydrolysate prepared by food‐grade thermoase PC10F (SPH‐T) has previously shown antihypertensive potential. In the present work, we further investigated its antihypertensive effect and underlying mechanisms in spontaneously hypertensive rats. There are three groups: untreated, low dose (250 mg SPH‐T/kg/day body weight), and high dose (1,000 mg SPH‐T/kg/day body weight). Oral administration of SPH‐T over a period of 20 days reduced systolic blood pressure by 25.7 mm Hg (p < 0.001) and 11.9 mm Hg (p < 0.05), respectively, for the high‐ and low‐dose groups. The high‐dose treatment decreased the circulating level of angiotensin II (from 25.0 to 5.7 pg/ml) while increased angiotensin‐converting enzyme 2 (ACE2) (from 1.3 to 3.3 IU/ml) and angiotensin (1–7) (from 37.0 to 70.1 pg/ml) significantly (p < 0.05). Furthermore, the high‐dose group doubled the aortic expression of ACE2 while reduced the expression of angiotensin (Ang) II type 1 receptor (by 35%). Circulating inflammatory cytokines including tumor necrosis factor alpha and monocyte chemoattractant protein‐1 as well as vascular inflammatory proteins including inducible nitric oxide synthase and vascular cell adhesion molecule‐1 were attenuated by ∼15%–50% by the treatment; nitrosative stress (35%) and type I collagen synthesis (50%) in the aorta were also attenuated significantly (p < 0.05). Moreover, SPH‐T possessed an umami taste (no obvious bitter taste) as analyzed by electronic tongue. Practical Application Hypertension is a global health concern, afflicting more than 20% of adults worldwide. Uncovering the antihypertensive effect of spent hen protein hydrolysate underpinned its functional food nutraceutical applications for the prevention and treatment of hypertension.

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“…The activity of LF, released systematically upon infection, is evidently anti-inflammatory and, in theory, should counteract the proteolytic performance of CatG. Although both CatG and LF cause vasodilatation mediated by nitric oxide ( Glusa and Adam, 2001 ; Garcia-Tejedor et al, 2017 ), in pathological conditions LF strongly inhibits nitric oxide production ( Kruzel et al, 2002 ) leading to suppression of vasodilation. In general, CatG activates platelets, which can be further enhanced by the combined action of LF and CatG as was determined by an increase of the platelet activation marker CD62P ( Eipper et al, 2016 ).…”

Section: General Aspects Of Neutrophil Serine Proteases In Inflammationmentioning

confidence: 99%

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

et al. 2021

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During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.

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Vasoactive properties of antihypertensive lactoferrin-derived peptides in resistance vessels: Effects in small mesenteric arteries from SHR rats

Abstract: In conclusion, LF-derived peptides show ex vivodirect and indirect relaxing effects in small mesenteric arteries from SHRs. These vasoactive effects would reduce vascular peripheral resistance in vivo, and thus contribute to their antihypertensive effects.

Cited by 9 publications

References 43 publications

Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

Chicken muscle hydrolysate reduces blood pressure in spontaneously hypertensive rats, upregulates ACE2, and ameliorates vascular inflammation, fibrosis, and oxidative stress

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

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