1993
DOI: 10.2527/1993.71102708x
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Vasoconstriction in bovine vasculature induced by the tall fescue alkaloid lysergamide2

Abstract: Treatment of bovine lateral saphenous vein (cranial branch) and dorsal metatarsal artery with lysergamide (lysergic acid amide), an alkaloid in abundance in tall fescue, resulted in vasoconstriction similar to that previously shown for the ergot alkaloids ergonovine and ergotamine. Preincubation of tissues with lysergamide resulted in partial inhibition of the contractile response induced by the selective adrenergic agents phenylephrine and BHT-920 (P < .05), indicating partial agonist or antagonist activity o… Show more

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Cited by 76 publications
(50 citation statements)
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“…Ergot alkaloids share structural similarity with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) (Klotz and Nicol, 2016) and exhibit dopaminergic, adrenergic, and serotonergic activities (Berde and Stürmer, 1978;Müller-Schweinitzer and Weidmann, 1978;Pertz and Eich, 1999) that influence numerous physiological functions (Dyer, 1993;Dyer, 2000;Klotz, 2015;Larson et al, 1995;Larson et al, 1994;Oliver, 1997Oliver, , 2005Oliver and Abney, 1989;Oliver et al, 1993;Vanhoutte and Luscher, 1986). Thus, EA can potentially decrease appetite and food intake through modulation of the hypothalamic serotonergic tone (Rossi-Fanelli and Cangiano, 1991).…”
Section: A N U S C R I P Tmentioning
confidence: 96%
See 1 more Smart Citation
“…Ergot alkaloids share structural similarity with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) (Klotz and Nicol, 2016) and exhibit dopaminergic, adrenergic, and serotonergic activities (Berde and Stürmer, 1978;Müller-Schweinitzer and Weidmann, 1978;Pertz and Eich, 1999) that influence numerous physiological functions (Dyer, 1993;Dyer, 2000;Klotz, 2015;Larson et al, 1995;Larson et al, 1994;Oliver, 1997Oliver, , 2005Oliver and Abney, 1989;Oliver et al, 1993;Vanhoutte and Luscher, 1986). Thus, EA can potentially decrease appetite and food intake through modulation of the hypothalamic serotonergic tone (Rossi-Fanelli and Cangiano, 1991).…”
Section: A N U S C R I P Tmentioning
confidence: 96%
“…Vasoconstrictive responses (Klotz et al, 2008;Oliver et al, 1993;Oliver et al, 1998;Rhodes et al, 1991) inducing perturbed nutrient absorption and metabolism (Egert et al, 2014a;Pesqueira et al, 2014) occur concurrently with altered circulating prolactin and cholesterol levels, which together with and intra-and extrahepatic enzyme activity changes, may play a role in the etiology of FT (Bacon, 1995;Rosenkrans and Ezell, 2015;Settivari et al, 2008;Thompson and Stuedemann, 1993;Zbib et al, 2014Zbib et al, , 2015. Foote et al (2013) suggested impaired weight gain might be attributed to a decrease in volatile fatty acid (VFA) absorption or production caused by increased ruminal EA concentration.…”
Section: A N U S C R I P Tmentioning
confidence: 98%
“…Vasoconstriction induced by PSCs or other toxins can hinder the ability to dissipate heat under warm conditions, sometimes dangerously so (e.g., fescue toxicosis; Oliver et al 1993), and other species of juniper contain PSCs that are vasoactive (Gardner et al 1998). McLister et al (2004) found that the thermoregulatory effect of juniper on N. albigula was most likely attributable to reduced heat dissipation (i.e., lower conductance), and the elevated T b observed for N. albigula that ate juniper in this study is also consistent with reduced heat dissipation.…”
Section: Pscs and Thermoregulationmentioning
confidence: 99%
“…1 The presence of endophyte in the plant results in the production of ergot alkaloids, which are toxic metabolites of N. coen-loids from endophyte-infected tall fescue affect the vascular tissues and blood of grazing organisms by acting on ␣-adrenergic, serotonin, and dopamine receptors to cause a vasoconstrictive response. 8,9 As ␣-adrenergic agonists, ergot alkaloids may decrease respiratory rates in sheep and cattle. The ergopeptides also suppress prolactin secretion by binding to dopamine receptors; prolactin concentration is, therefore, often used as an indicator of fescue toxicosis in livestock.…”
mentioning
confidence: 99%