Vasoconstriction in the hand during electrical stimulation of the lumbar sympathetic chain in man

Cooper, K. E.; Kerslake, D. McK.

doi:10.1113/jphysiol.1955.sp005243

Cited by 12 publications

(8 citation statements)

References 4 publications

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“…There is also evidence that stimulation of Circulation Research, Volume XXIII, December 1968 cutaneous thermal receptors initiates reflexes to control heat transfer from (and heat production by) the body (15)(16)(17). Measurements of the total thermal and metabolic responses of the unanesthetized dog to localized heating and cooling of the hypothalamus at various environmental temperatures led Fusco and co-workers (18) to conclude that the thermoregulatory responses were due to a summing of the central and peripheral thermal drives.…”

Section: Discussionmentioning

confidence: 99%

Response of Dogs' Cutaneous Veins to Local and Central Temperature Changes

Webb-Peploe

Shepherd

1968

Circulation Research

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To study the separate actions of peripheral and central temperaturesensitive systems on the cutaneous veins of the dog, a cross-circulation preparation was made in which hindleg and central temperatures could be varied independently. The lateral saphenous vein of a vascularly isolated hindleg was cross-perfused at constant flow; the difference between perfusion and femoral vein pressures was a measure of venomotor activity. With central temperature constant, local cooling of one leg from 47° to 17°C caused the lateral saphenous vein to constrict; sensitivity to cooling was maximal between 42° and 27°C. With leg temperature constant, central cooling caused the lateral saphenous vein to constrict; over the range of 40° to 33°C, the constriction was linearly related to the decrease in temperature. Central heating reduced the response to local cooling, whereas central cooling had the opposite effect. Thus a decrease in central temperature from 38° to 34°C increased the venoconstrictor response to local cooling from 42° to 22°C by a factor of ten or more. SHEPHERD MICHAEL M. WEBB-PEPLOE and JOHN T.

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Section: Discussionmentioning

confidence: 99%

Response of Dogs' Cutaneous Veins to Local and Central Temperature Changes

Webb-Peploe

Shepherd

1968

Circulation Research

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“…The afferent fibers did not run with other sensory fibers, because cutting the appropriate dorsal spinal roots did not abolish the temperature response. Cooper and Kerslake (4,5) have suggested that afferent fibers from temperature receptors run in the lumbar sympathetic nerve chains in man. However, in the present experiments in the dog, section of the upper lumbar dorsal roots in the region of the sympathetic outflow to the hindlegs failed to abolish the response (3).…”

Section: Discussionmentioning

confidence: 99%

Peripheral Mechanism Involved in Response of Dogs' Cutaneous Veins to Local Temperature Change

Webb-Peploe

Shepherd

1968

Circulation Research

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The cutaneous veins of the dog constrict and dilate with local cooling and warming, respectively. This response, which is dependent on the integrity of the adrenergic nerves, might be explained by an altered response of the smooth muscle to a given frequency of sympathetic nerve impulses or by local temperature receptors that initiate alterations in sympathetic nerve activity. In the lateral saphenous vein perfused at 42°, 27°, and 17°C, the constriction caused by stimulation of lumbar sympathetic nerves was 40%, 160%, and 200%, respectively, of that at 37°C; the constriction caused by norepinephrine at the same temperatures was 70%, 187%, and 318% of that at 37°C. Division of the dorsal spinal roots from L-l to S-l made no difference to the venoconstrictor response to local cooling. It is concluded that an alteration in the sensitivity of the smooth muscle to arriving sympathetic nerve impulses accounts for the venous responses to local temperature changes seen in the intact dog.ADDITIONAL KEY WORDS norepinephrine and temperature veins and temperature local temperature and veins temperature and sympathetic impulses veins and norepinephrine posterior nerve roots and veins venomotor reflexes• Previous studies (1, 2) have shown that the superficial limb veins of the dog constrict in response to either a decrease in central temperature or to a cooling of the blood perfusing the vein. Whereas central cooling causes constriction of the cutaneous veins in all the limbs, the constriction with local cooling is confined to the cooled limb. The magnitude of the response to a fixed local cold stimulus is governed by the central temperature; with a decrease in central""temperature of -a few degrees -the Te= sponse is much greater, whereas after central warming it is much less. The response to changes in both local and central tempera-

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“…Studies of the anaesthetized cat suggest that stimulation of splanchnic nerves can be conducted up the paravertebral sympathetic chain and enter the spinal cord via the posterior roots from T3 to LI (Bain, Irving, and McSwiney, 1935). Cooper and Kerslake (1955) have also shown in anaesthetized human subjects that vasoconstriction in the hand can be evoked by stimulating the lumbar sympathetic chain. Furthermore, clinical observations of paraplegic patients indicate that a substantial proportion of these individuals complain of diffuse, sometimes painful sensations in the lower body which are associated with distension of the bladderor bowels (Foerster, 1936; Davis and Martin, 1947;Guttmann and Whitteridge, 1947;Kuhn, 1950;Bene §, 1968).…”

Section: Discussionmentioning

confidence: 99%

Analysis of electrodermal evidence for a paramedullary afferent tract in patients with a transection of the thoracic spinal cord

Fuhrer

1971

Journal of Neurology, Neurosurgery & Psychiatry

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Vasoconstriction in the hand during electrical stimulation of the lumbar sympathetic chain in man

Cited by 12 publications

References 4 publications

Response of Dogs' Cutaneous Veins to Local and Central Temperature Changes

Response of Dogs' Cutaneous Veins to Local and Central Temperature Changes

Peripheral Mechanism Involved in Response of Dogs' Cutaneous Veins to Local Temperature Change

Analysis of electrodermal evidence for a paramedullary afferent tract in patients with a transection of the thoracic spinal cord

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