Vasoconstrictive action of neuropeptide Y in Bone: The porcine tibia perfused in vivo

Lindblad, Bent Erling; Nielsen, Lars Bo; Jespersen, Stig; Bjurholm, Anders; Bünger, Cody; Hansen, Ebbe Stender

doi:10.3109/17453679408994619

Cited by 24 publications

(12 citation statements)

References 14 publications

(13 reference statements)

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“…SP is a potent mediator of increased microvascular permeability, leading to inflammatory swelling, through its action on NK 1 receptors on postcapillary endothelial cells [63]. In addition, the autonomic neuropeptide NPY causes vasoconstriction of peripheral blood vessels, which has also been confirmed in bone [64].…”

Section: Discussionmentioning

confidence: 99%

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

Wang

et al. 2010

Osteoporos Int

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Section: Discussionmentioning

confidence: 99%

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

Wang

et al. 2010

Osteoporos Int

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“…However, the vascular bed is difficult to approach, and only very little is known about the vasoregulating mechanisms in bone tissue. Hitherto, the regulatory processes of bone perfusion have mainly been studied in perturbation studies in intact animals [21] and in the artificially perfused tibia [ 13,14,25]. In humans, bone perfusion has been assessed in studies with radioactive labeled tracers [34,39].…”

Section: Introductionmentioning

confidence: 99%

Adrenergic responses in human small arteries isolated from the femoral neck

Lundgaard

Aalkjær

Bünger

et al. 2001

Journal Orthopaedic Research

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Many pathological bone conditions are accompanied by changes in bone perfusion. However, no method has yet allowed investigation of vascular reactivity in human bone tissue. In the present study, arterial segments (diameter = 0.25 mm) were isolated from human bone biopsies and mounted as ring preparations in vitro. The viability of the arteries and the effects of adrenoceptor stimulations were investigated. Combined a-and 0-adrenoceptor stimulation (noradrenaline 10-8-10-5 M) and specific cyIadrenoceptor stimulation (phenylephrine, 10-8-10-4.5 M ) induced ' concentration-dependent contractions in all arteries. Selective stimulation of a2-receptors (B-HT 933, 1 O-R-10-'.5 M) only induced contraction in three of eight arteries. Stimulation of 0-receptors with isoprenaline ( M ) resulted in vasorelaxation in 3 of 10 arteries. In all arteries, acetylcholine ( 10-'0-10-5 M ) induced vasorelaxation, demonstrating preserved function of the endothelium. The results suggest that primarily a1 -receptors are responsible for adrenoceptor induced vasoconstriction in human bone while functional a?-and 0-receptors may not be consistently expressed. The model is the first to allow investigations on vascular reactivity in human bone tissue and may become valuable for assessment of both normal and pathological bone physiology.

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“…The reason of enhancing the vascularization by implanting the sensory nerve fiber may be related with the capillary network distributed in the sensory nerve fiber. These neuropeptides of CGRP and NPY secreted from the sensory nerve are also associated with the dilation and the constriction of blood vessels through interaction with neuropeptide receptors present on both endothelial cells and vascular smooth muscle cells via endothelium-dependent or endothelium-independent mechanisms, depending on the vessel type and species [33–38]. …”

Section: Discussionmentioning

confidence: 99%

Different Effects of Implanting Sensory Nerve or Blood Vessel on the Vascularization, Neurotization, and Osteogenesis of Tissue-Engineered Bone In Vivo

Fan

Qin

et al. 2014

BioMed Research International

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To compare the different effects of implanting sensory nerve tracts or blood vessel on the osteogenesis, vascularization, and neurotization of the tissue-engineered bone in vivo, we constructed the tissue engineered bone and implanted the sensory nerve tracts (group SN), blood vessel (group VB), or nothing (group Blank) to the side channel of the bone graft to repair the femur defect in the rabbit. Better osteogenesis was observed in groups SN and VB than in group Blank, and no significant difference was found between groups SN and VB at 4, 8, and 12 weeks postoperatively. The neuropeptides expression and the number of new blood vessels in the bone tissues were increased at 8 weeks and then decreased at 12 weeks in all groups and were highest in group VB and lowest in group Blank at all three time points. We conclude that implanting either blood vessel or sensory nerve tract into the tissue-engineered bone can significantly enhance both the vascularization and neurotization simultaneously to get a better osteogenesis effect than TEB alone, and the method of implanting blood vessel has a little better effect of vascularization and neurotization but almost the same osteogenesis effect as implanting sensory nerve.

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Vasoconstrictive action of neuropeptide Y in Bone: The porcine tibia perfused in vivo

Cited by 24 publications

References 14 publications

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

Adrenergic responses in human small arteries isolated from the femoral neck

Different Effects of Implanting Sensory Nerve or Blood Vessel on the Vascularization, Neurotization, and Osteogenesis of Tissue-Engineered Bone In Vivo

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