Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2α on human umbilical vein

Daray, Federico Manuel; Minvielle, Ana Itatí; Puppo, Soledad; Rothlin, Rodolfo Pedro

doi:10.1016/j.ejphar.2004.07.100

Cited by 14 publications

(7 citation statements)

References 32 publications

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“…Once released from cell membranes by phospholipases, isoprostanes circulate in the plasma in free forms and are therefore susceptible to activate membrane receptors. The available data strongly suggest that the effects of 15-F 2t -IsoP on blood vessels are mediated by the activation of the TP receptors (thromboxane A 2 /prostaglandin H 2 receptors), acting as a full or partial agonist [24,25], although some responses including mitogenesis appear to be at least in part TP receptor independent. 15-F 2t -IsoP is a vasoconstrictor in most species and vascular beds, both in vitro and in vivo, following intravenous administration (see [21,22] for full reviews).…”

Section: A S C U L a R P H A R M A C O L O G Y O F T H E I S O P R mentioning

confidence: 99%

“…In addition, it stimulates mitogenesis in uterine vascular smooth muscle cells [23]. The available data strongly suggest that the effects of 15-F 2t -IsoP on blood vessels are mediated by the activation of the TP receptors (thromboxane A 2 /prostaglandin H 2 receptors), acting as a full or partial agonist [24,25], although some responses including mitogenesis appear to be at least in part TP receptor independent. The existence of a specific isoprostane receptor has been suggested but remains to be elucidated [26].…”

Section: A S C U L a R P H A R M A C O L O G Y O F T H E I S O P R mentioning

confidence: 99%

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Cardiovascular pharmacology and physiology of the isoprostanes

Cracowski¹

2006

Fundamemntal Clinical Pharma

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F(2)-isoprostanes are a complex family of compounds produced from arachidonic acid via a free radical-catalyzed mechanism. Their quantification as a pathophysiological biomarker provides a unique opportunity to investigate lipid peroxidation in vascular diseases. Their measurement also provides an interesting biomarker for the rational dose selection of antioxidants in vascular diseases where oxidative stress might be involved. In addition to their use as biomarkers, some isoprostanes possess a biological activity. The 15-series F(2)- and E(2)-isoprostanes mediate vasoconstriction in different vascular beds and species. In addition, 15-F(2t)-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. The data available supports but does not prove the hypothesis that isoprostanes are involved in vascular physiology and pathogenesis.

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Section: A S C U L a R P H A R M A C O L O G Y O F T H E I S O P R mentioning

confidence: 99%

Section: A S C U L a R P H A R M A C O L O G Y O F T H E I S O P R mentioning

confidence: 99%

Cardiovascular pharmacology and physiology of the isoprostanes

Cracowski¹

2006

Fundamemntal Clinical Pharma

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“…These ex vivo studies were consistent with studies in humans (27) and other animals (34) demonstrating that inhalation of U-46619 results in rapid bronchoconstriction (12). Furthermore, some studies have even suggested that other constricting prostanoids, such as PGF 2 and PGD 2 , may mediate constriction by binding the TP receptor (10,14).…”

mentioning

confidence: 97%

Thromboxane A₂induces airway constriction through an M₃muscarinic acetylcholine receptor-dependent mechanism

Allen

Hartney²,

Coffman

et al. 2006

American Journal of Physiology-Lung Cellular and Molecular Phys

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Thromboxane A2 (TXA2) is a potent lipid mediator released by platelets and inflammatory cells and is capable of inducing vasoconstriction and bronchoconstriction. In the airways, it has been postulated that TXA2 causes airway constriction by direct activation of thromboxane prostanoid (TP) receptors on airway smooth muscle cells. Here we demonstrate that although TXA2 can mediate a dramatic increase in airway smooth muscle constriction and lung resistance, this response is largely dependent on vagal innervation of the airways and is highly sensitive to muscarinic acetylcholine receptor (mAChR) antagonists. Further analyses employing pharmacological and genetic strategies demonstrate that TP-dependent changes in lung resistance and airway smooth muscle tension require expression of the M2 mAChR subtype. These results raise the possibility that some of the beneficial actions of anticholinergic agents used in the treatment of asthma and chronic obstructive pulmonary disease result from limiting physiological changes mediated through the TP receptor. Furthermore, these findings demonstrate a unique pathway for TP regulation of homeostatic mechanisms in the airway and suggest a paradigm for the role of TXA2 in other organ systems.

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“…Previous cell-culture studies found an increase of isoprostane synthesis in mesangial and endothelial glomerular cells in a high glucose state [ 33 ]. 8-iso-PGF 2 α is known to have biological activity as a strong vasoconstrictor [ 14 , 34 ]. Increasing synthesis of 8-iso-PGF 2 α in the kidneys was reported as increasing the activation of kidney TGF-β in rats with type 1 diabetes [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Role of urinary H2O2, 8-iso-PGF2α, and serum oxLDL/β2GP1 complex in the diabetic kidney disease

et al. 2022

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Oxidant species is reported as a major determinant in the pathophysiology of diabetic kidney disease. However, reactive oxygen species (ROS) formation in the initial phase and progressing phase of diabetic kidney disease remains unclear. Therefore, we conducted this study to find out what ROS and their modified product are associated with eGFR in type 2 diabetes mellitus (T2DM) patients. A cross-sectional study was performed on 227 T2DM patients. The study subjects were divided into three groups based on their eGFR stage (Group 1, eGFR > 89 ml/min/1.73 m2; Group 2, eGFR = 60–89 ml/min/1.73 m2; and Group 3, eGFR < 60 ml/min/1.73 m2). Enzyme-linked immunosorbent assay (ELISA) was used to measure serum oxLDL/β2GPI complex and urinary 8-iso-PGF2α, while ferrous ion oxidation xylenol orange method 1 (FOX-1) was used to measure urinary hydrogen peroxide (H2O2). H2O2 significantly decreased across the groups, whereas OxLDL/β2GPI complex increased, but not significant, and there was no trend for 8-iso-PGF2α. Consistently, in the total study population, only H2O2 showed correlation with eGFR (r = 0.161, p = 0.015). Multiple linear regression analysis showed that significant factors for increased eGFR were H2O2, diastolic blood pressure, and female. Whereas increased systolic blood pressure and age were significant factors affecting the decrease of eGFR. We also found that urinary H2O2 had correlation with serum oxLDL/β2GPI complex in total population. This finding could lead to further research on urinary H2O2 for early detection and research on novel therapies of diabetic kidney disease.

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Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2α on human umbilical vein

Cited by 14 publications

References 32 publications

Cardiovascular pharmacology and physiology of the isoprostanes

Cardiovascular pharmacology and physiology of the isoprostanes

Thromboxane A₂induces airway constriction through an M₃muscarinic acetylcholine receptor-dependent mechanism

Role of urinary H2O2, 8-iso-PGF2α, and serum oxLDL/β2GP1 complex in the diabetic kidney disease

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Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2α on human umbilical vein

Cited by 14 publications

References 32 publications

Cardiovascular pharmacology and physiology of the isoprostanes

Cardiovascular pharmacology and physiology of the isoprostanes

Thromboxane A2induces airway constriction through an M3muscarinic acetylcholine receptor-dependent mechanism

Role of urinary H2O2, 8-iso-PGF2α, and serum oxLDL/β2GP1 complex in the diabetic kidney disease

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Thromboxane A₂induces airway constriction through an M₃muscarinic acetylcholine receptor-dependent mechanism