Vasoconstrictor reactions in spontaneously hypertensive rats versus Wistar Kyoto can be increased or decreased depending on the conditions of perfusion

Rodionov, I. M.; Tarasova, O. S.; Vakulina, T. P.; Koshelev, V. B.; Pinelis, Vsevolod; Markov, C

doi:10.1111/j.1748-1716.1992.tb09407.x

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…An opposite relationship was observed at constant pressure perfusion: the vasoconstrictor response to noradrenaline being more prominent in the WKY vessel. These data are in agreement with earlier results (Rodionov et al 1992) obtained on hindquarters of SHR and WKY.…”

Section: Discussionsupporting

confidence: 94%

“…At high values of wall tension the difference in the response to extrinsic stimulation should be determined mainly by the media thickness: the greater the media thickness the greater the narrowing of the lumen. Actually, at high constant perfusion pressure (200 mmHg) the ef®ciency of vasoconstrictor stimulation in SHR became greater than in WKY (Rodionov et al 1992). Results of the experiments with constant¯ow perfusion support this point of view.…”

Section: Discussionmentioning

confidence: 65%

“…In contrast to the above-quoted data it was shown that under constant pressure perfusion at a moderate pressure level vasoconstrictor responses in SHR are weaker than those of WKY (Rodionov et al 1992). An analysis of these phenomena is expedient on the entire organic vasculature where vessels with a different order of branching exhibit different reactivity to vasoconstrictor agents and to changes in intraluminal pressure (Marshall et al 1987, Maspers et al 1990).…”

mentioning

confidence: 62%

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Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure

Machkov

Tarasova

Timin

et al. 1997

Acta Physiologica Scandinavica

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Vasoconstrictor effects of noradrenaline were compared in 6- to 7-month-old spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. A cylindrical segment was dissected from the proximal part of tail artery, cannulated at both ends and perfused alternately either at constant flow or constant pressure. Two series of experiments were performed. In the first series, vessels were perfused/superfused with Krebs-Henseleit solution. In the second one a modified salt solution was used, in which NaCl was totally replaced by an equimolar amount of KCI. Under constant flow conditions noradrenaline evoked a more prominent resistance increase in SHR compared with WKY independently of the composition of solution (normal or high-K+) used. At constant pressure perfusion with normal solution, the vasoconstrictor response to noradrenaline was more prominent in WKY. Under application of high-K+ solution, vasoconstriction at constant pressure in SHR became more pronounced than that in WKY. We suggest that there is greater wall thickness:lumen diameter ratio in SHR vessels and thus different contribution of distension-activated myogenic response is of primary importance for the data obtained.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 65%

mentioning

confidence: 62%

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Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure

Machkov

Tarasova

Timin

et al. 1997

Acta Physiologica Scandinavica

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“…It was shown that the myogenic response ampli®es the vasoconstriction induced by extrinsic stimulation (Meininger & Trzeciakowski 1988, Meininger & Faber 1991. Recently we have studied this phenomenon in perfused vessels from SHR and WKY rats (Rodionov et al 1992, Machkov et al 1997. In accordance with others (Folkow et al 1970, Cassis et al 1985, in these experiments vasoconstriction induced by noradrenaline or nerve stimulation under constant±¯ow perfusion in SHR was greater compared to WKY.…”

supporting

confidence: 78%

Responses to noradrenaline of tail arteries in hypertensive, hypotensive and normotensive rats under different regimens of perfusion: role of the myogenic response

et al. 1998

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The vasoconstrictor effects of noradrenaline were studied in spontaneously hypertensive rats (SHR) compared with Wistar Kyoto rats (WKY), and in Wistar rats with regional hypotension (WH) compared to control Wistar rats (WC). The abdominal aorta was ligated in WH distal to the renal arteries, lowering blood pressure in the hindquarters by 41% and tail artery wall cross-sectional area by 35% compared with WC. A cylindrical segment was dissected from the proximal part of the tail artery, cannulated at both ends and perfused with Krebs-Henseleit solution either at constant flow starting from a pressure of 120 mmHg or at a constant pressure of 120 mmHg. The cumulative dose± response relationships for noradrenaline were determined in control conditions and subsequently in the presence of gadolinium (100 lM), a non-speci®c blocker of mechanosensitive channels. Under constant-¯ow perfusion noradrenaline evoked a more prominent resistance increase in SHR compared with WKY and in WC compared with WH. Similar relations were seen in the presence of gadolinium, although responses were reduced. At constant pressure perfusion the vasoconstrictor response to noradrenaline was lower in SHR compared with WKY and in WC compared with WH. Application of gadolinium under constant-pressure perfusion reduced responses in WKY and WH, so that vasoconstriction in SHR became more pronounced than that in WKY and in WC than that in WH. It is suggested that the results can be explained by the difference in wall thickness causing different degrees of activation of the myogenic response to distension.

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“…In contrast to the above‐quoted data it was shown that under constant pressure perfusion at a moderate pressure level, vasoconstrictor responses in SHR are weaker than those of WKYR (Rodionov et al ., 1992). An analysis of these phenomena is expedient on the entire organic vasculature where vessels with a different order of branching exhibit different reactivity to vasoconstrictor agents and to changes in intraluminal pressure (Maarshall, 1982; Maspers, Bjomberg, Grand & Mellander, 1990).…”

Section: Introductionmentioning

confidence: 83%

Comparison of catecholamine release in the isolated adrenal glands of SHR and WKY rats

Lim¹,

Jang

Park³

2002

Auton Autocoid Pharmacol

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1 The present study was designed to investigate the secretion of catecholamines (CA) evoked by stimulation of cholinergic receptors and membrane depolarization from the isolated perfused adrenal gland of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKYR) at adult age. 2 The wet weight of adrenal gland in SHR was greater than that in WKYR. The CA releasing responses evoked by acetylcholine (5.32 x 10-3 m), and high potassium (5.6 x 10-2 m), a membrane depolarizer, were significantly lower in WKYR than in SHR. 3 The secretory responses of CA evoked by DMPP (10-4 m for 2 min), a selective agonist of neuronal nicotinic receptors, and McN-A-343 (10-4 m for 2 min), a selective agonist of neuronal muscarinic receptors, were also significantly lower in WKYR than in SHR. 4 The CA release evoked by Bay-K-8644 (10-5 m), a dihydropyridine-sensitive Ca2+ channel activator, and cyclopiazonic acid (10-5 m), a selective inhibitor of Ca2+-ATPase in the endoplasmic reticulum, were also significantly greater in SHR than WKYR. 5 Taken together, these experimental results demonstrate that the CA secretion evoked by stimulation of cholinergic (nicotinic and muscarinic) receptors as well as membrane depolarization is enhanced more greatly in the perfused adrenal glands of SHR than in those of WKYR. It is suggested that the augmented CA release in SHR compared with WKYR was involved in essential hypertensive pathogenesis.

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Vasoconstrictor reactions in spontaneously hypertensive rats versus Wistar Kyoto can be increased or decreased depending on the conditions of perfusion

Cited by 6 publications

References 18 publications

Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure

Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure

Responses to noradrenaline of tail arteries in hypertensive, hypotensive and normotensive rats under different regimens of perfusion: role of the myogenic response

Comparison of catecholamine release in the isolated adrenal glands of SHR and WKY rats

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