Vasoconstrictor responses of isolated pig coronary arteries.

Ikenoue, Kouichi; Kawakita, Seiichi; Toda, Noboru

doi:10.1254/fpj.87.281

Cited by 6 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4). These are in agreement with earlier work (12). However, in this experiment, 3 X 10-5 M and 104 M histamine-induced contractions were potentiated by cimetidine (Fig.…”

Section: Discussionsupporting

confidence: 94%

“…5 and Table 3). These results are in agreement with those of Ikenoue et al (12). They also have reported that the pretreatment of indomethacin (10-6 M) did not affect the histamine-induced contraction in pig coronary arteries with endothelium.…”

Section: Discussionsupporting

confidence: 93%

“…These results suggest that the endothelium of the pig coronary artery has H1-receptors that may stimulate the release of EDRF. This is in agreement with the previous suggestion (12). In the cattle coronary arteries, the slope value of the Schild plot was less than unity even after the removal of endothelium, but the slope value was significantly increased and become unity in the presence of 10-5 M cimetidine (Fig.…”

Section: Discussionsupporting

confidence: 93%

“…2, the isolated pig and cattle coronary arteries were contracted by histamine. These results were similar to previous reports in pigs (12,13) and cattle (3,14). In pig coronary arteries, removal of the endothelium increased the maximal response and pD2 value of the histamine-induced contraction ( Fig.…”

Section: Discussionsupporting

confidence: 92%

“…Histamine has been reported to contract pig and cattle coronary arteries in vitro (3,4,12,13), but there are few data about the subtypes of histamine receptors and whether vascular responses to histamine are endothelium-dependent or not in these species (12,13). As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

View full text Add to dashboard Cite

ABSTRACT-Vasomotor effects of histamine were examined in isolated coronary arteries from pigs and cattle. Histamine produced a concentration-dependent contraction in these arteries. These contractile responses were dose-dependently inhibited by diphenhydramine. The slopes of the Schild plots, however, were significantly lower than unity in both species. Cimetidine potentiated the histamine-induced contractions at relatively high doses of histamine (larger than 10-5 M) in pig coronary arteries, but did not show a significant effect in cattle arteries. After the removal of endothelium, the Schild plot of diphenhydramine against histamine gave a straight line with a pA2 value of 7.80 and slope of 1.00 in pigs, confirming the competitive nature of the antagonism. In cattle, the slope was significantly lower than unity; however, in the presence of cimetidine, it was not significantly different from unity. Dimaprit did not contract the cattle coronary arteries with endothelium, but contracted them after the removal of endothelium. These results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the Hi-receptors in the smooth muscle cells, and that H1-and H2-receptors in the endothelial cells of pigs and H2-receptors in the smooth muscle cells of cattle modify the histamine-induced vasoconstrictions. Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10

show abstract

“…4). These are in agreement with earlier work (12). However, in this experiment, 3 X 10-5 M and 104 M histamine-induced contractions were potentiated by cimetidine (Fig.…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%