Vasodilator and hypotensive effects of the spider peptide Lycosin-I in vitro and in vivo

Ma, Binbin; Xi, Zhouhuan; Li, Jiahui; Gao, Tianqi; Liao, Runzhi; Wang, Shuhang; Li, Xianyao; Tang, Yaqin; Wang, Zheng; Hou, Shengjie; Jiang, Jialiang; Deng, Mei; Duan, Zhigui; Xing, Tao; Jiang, Liping

doi:10.1016/j.peptides.2017.12.011

Cited by 13 publications

(5 citation statements)

References 47 publications

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“…NO is a messenger molecular medium that provides multiple functions in biological tissues [ 52 ]. Previous studies have shown that the production of NO is one of the potential mechanisms for the prevention and treatment of hypertension [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Wu¹,

Luo

Zhang

et al. 2023

Nutrients

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Torreya grandis meal has a high protein content and an appropriate amino acid ratio, making it an excellent protein source for producing ACE inhibitory peptides. To promote its application in food, medicine, and other fields, an alkaline protease hydrolysate of Torreya grandis was used in this study to isolate and identify a novel angiotensin-converting enzyme inhibitory peptide, VNDYLNW (VW-7), using ultrafiltration, gel chromatography purification, LC-MS/MS, and in silico prediction. The results show that the IC50 value of VW-7 was 205.98 µM. The Lineweaver–Burk plot showed that VW-7 had a mixed-type inhibitory effect on ACE. Meanwhile, according to the results of molecular docking, VW-7 demonstrated a strong affinity for ACE (binding energy −10 kcal/mol). VW-7 was bound to ACE through multiple binding sites. In addition, VW-7 could remain active during gastrointestinal digestion in vitro. Nitric oxide (NO) generation in human endothelial cells could rise after receiving a pretreatment with VW-7. These results indicated that Torreya grandis meal protein can be developed into products with antihypertensive function, and VW-7 has broad application prospects in the field of antihypertensive.

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Section: Resultsmentioning

confidence: 99%

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Wu¹,

Luo

Zhang

et al. 2023

Nutrients

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“…In addition to its anti-cancer activity, Lycosin-I (discussed above in 'Anti-cancer peptides', and below in 'Modulators of NF-κB signaling' and 'Anti-pathogenic peptides') has also been implicated as a potential treatment for hypertension due to its recently-characterised effects on the endothelial nitric oxide signaling pathway (Ma et al, 2018).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Versatile spider venom peptides and their medical and agricultural applications

Saez

Herzig

2019

Toxicon

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Spiders belonging to the Theraphosidae family, also known as tarantulas, produce venoms composed mainly of peptide toxins that target ion channels of the nervous system ( Escoubas and Rash, 2004 ; Klint et al, 2012 ). However, some studies suggest that spider venoms also contain vasodilator compounds, most of them acting by endothelium-dependent mechanisms that involve activation of nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) as the primary pathway ( Weinberg et al, 2002 ; Lee et al, 2007 ; Rattmann et al, 2008 ; Horta et al, 2013 ; Ma et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Vasodilator activity of Poecilotheria ornata venom involves activation of the NO/cGMP pathway and inhibition of calcium influx to vascular smooth muscle cells

de Jesus-López,

Cuéllar-Balleza,

Díaz-Peña

et al. 2023

Toxicon: X

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Vasodilator and hypotensive effects of the spider peptide Lycosin-I in vitro and in vivo

Cited by 13 publications

References 47 publications

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Versatile spider venom peptides and their medical and agricultural applications

Vasodilator activity of Poecilotheria ornata venom involves activation of the NO/cGMP pathway and inhibition of calcium influx to vascular smooth muscle cells

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