Vasodilator effects of dopaminomimetics in the perfused rat kidney

Schmidt, M; Jl, Imbs; Giesen, Eva Maria; Schwartz, Jean

doi:10.1016/0014-2999(82)90157-1

Cited by 20 publications

(6 citation statements)

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“…On the other hand. SKF 38393 in duced a partial agonist activity, which is in agreement with other data reported [Schmidt et al, 1982]. Vasoconstriction, or lack of effects were not observed, as in other prepa rations [Urquilla, 1976;Edvinsson et al, 1978;Goldberg, 1978;Oudart et al.…”

Section: Discussionsupporting

confidence: 82%

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Rodriguez-Mendez¹,

Feria²,

Boada³

1986

Pharmacology

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The effects of two dopamine agonists, dopamine itself and SKF 38393, alone and in the presence of several dopamine antagonists, have been studied in the partially contracted, isolated and perfused renal artery of the rat. In this preparation, earlier used by other authors in vascular pharmacological experiments, the dopaminergic agents produced clear vasodilator effects which were inhibited by all antagonists used. Due to its low cost and simplicity, such a preparation would be of practical value in testing dopaminergic drugs.

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Section: Discussionsupporting

confidence: 82%

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Rodriguez-Mendez¹,

Feria²,

Boada³

1986

Pharmacology

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“…Therefore, an alteration in renal flow regulation seems also involved. This could be due to an a-receptor-mediated vasoconstriction, second ary to the blockade of beta-2-receptors present in renal vasculature [ 15], or to nonspecific factors involved in the control of renal hemodynamics, such as dopamine or the prostaglandin/kallikrcin system [16][17][18],…”

Section: Discussionmentioning

confidence: 99%

Renal Hemodynamic Effects of Tertatolol Compared with Those of Propranolol in the Conscious Dog

Laubie

Prost²,

Rochat³

1986

Am J Nephrol

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Experiments were performed in which the effects of two β-blockers, tertatolol [dl-(hydroxy-2’-t-butyl-amino-3’-propyloxy)-8-thiochroman hydrochloride] and propranolol, on mean arterial pressure (MAP), heart rate (HR), and renal function were studied in the conscious sodium-replete dog. In all experiments renal function was evaluated from the effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) assessed respectively by measurement of p-aminohippurate and creatinine clearances. These parameters were measured during two 30-min control periods, after which two further measurements were performed over a similar time period, after intravenous administration of either propranolol (0.5 mg·kg^-1; n = 8) or tertatolol (0.05 mg·kg^-1; n = 8), these two doses being of equivalent β-adrenoceptor antagonist activity. Administration of propranolol and tertatolol did not change MAP but induced a significant and comparable decrease in HR. After propranolol a significant decrease in ERPF was observed, without any change in GFR or sodium excretion. In contrast, administration of tertatolol resulted in no modification of ERPF, a slight but significant increase in GFR, and a significant increase in sodium and potassium excretion. These results suggest that tertatolol and propranolol though acting similarly on systemic parameters have different effects on renal hemodynamics in the conscious dog.

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“…While some relaxation was observed with this compound, it was not concentration-dependent , and the concentration required to observe this action was much greater than that produced by SKF 82526. The isolated perfused rat kidney has been used to study the renal vascular DA1 receptors in that dopamine and dopamine receptor agonists are shown to cause dilatation in this preparation by activating the DAI receptors located on renal blood vessels (Woodman, Rechtman & Lang, 1980;Schmidt & Imbs, 1980;Schmidt, Imbs, Giesen & Schwartz, 1982). The failure of LY 171555 to cause renal vasodilation in our study provides the first direct evidence that this compound does not activate the renal vascular DA1 receptors.…”

Section: Discussionmentioning

confidence: 62%

EVALUATION OF THE EFFECTS OF SKF 82526 AND LY 171555 ON PRESYNAPTIC (DA₂) AND POSTSYNAPTIC (DA₁) DOPAMINE RECEPTORS IN RAT KIDNEY

Lokhandwala

Steenberg

1984

Journal of Autonomic Pharmacology

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Effects of dopamine receptor agonists, SKF 82526 and LY 171555 on presynaptic (DA2) and postsynaptic (DA1) dopamine receptors were studied in the isolated perfused rat kidney. SKF 82526 failed to alter [3H]NA release elicited during periarterial nerve stimulation in the kidney whereas LY 171555 caused a concentration-dependent inhibition of the stimulus-induced release of [3H]NA. This inhibitory action of LY 171555 could be antagonized by sulpiride but not by SCH 23390. SKF 82526 caused concentration-dependent renal vasodilation which could be antagonized by SCH 23390. LY 171555 did not produce significant changes in renal perfusion pressure over a wide range of concentrations. These results show that SKF 82526 and LY 171555 are selective agonists at DA1 and DA2 receptors respectively. These agents represent an important class of compounds that would be useful for pharmacological characterization of peripheral dopamine receptors.

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Vasodilator effects of dopaminomimetics in the perfused rat kidney

Cited by 20 publications

References 20 publications

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Renal Hemodynamic Effects of Tertatolol Compared with Those of Propranolol in the Conscious Dog

EVALUATION OF THE EFFECTS OF SKF 82526 AND LY 171555 ON PRESYNAPTIC (DA₂) AND POSTSYNAPTIC (DA₁) DOPAMINE RECEPTORS IN RAT KIDNEY

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Vasodilator effects of dopaminomimetics in the perfused rat kidney

Cited by 20 publications

References 20 publications

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Renal Hemodynamic Effects of Tertatolol Compared with Those of Propranolol in the Conscious Dog

EVALUATION OF THE EFFECTS OF SKF 82526 AND LY 171555 ON PRESYNAPTIC (DA2) AND POSTSYNAPTIC (DA1) DOPAMINE RECEPTORS IN RAT KIDNEY

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EVALUATION OF THE EFFECTS OF SKF 82526 AND LY 171555 ON PRESYNAPTIC (DA₂) AND POSTSYNAPTIC (DA₁) DOPAMINE RECEPTORS IN RAT KIDNEY