Vasodilator therapy for right ventricular failure.

Sakaguchi, Kazushige; Tanaka, Nobuyuki; Sawada, Masateru; Araki, Yoshihiko; Fujita, Kazushige

doi:10.1253/jcj.48.357

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…Other vasodilators, including molsidomine, had no beneficial effect on hemodynamics or oxygen Nitroprusside does not produce sustained hemodyn'amic benefits. The effects of the prostaglandin, alprostadil, included a reduction in PAP and PVR, resulting in an increase in CO and oxygen 208 Similar effects were seen with the oral administration of a PGE, analog, OP-1 206.209 Epoprostenol produced immediate hemodynamic benefit in some, but not all, 210 Studies of extended treatment with prostaglandins are necessary to evaluate if hemodynamic effects are sustained and to determine the clinical benefits of the hemodynamic effects.…”

Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 94%

Pharmacologic Treatment of Primary and Secondary Pulmonary Hypertension

Brown

1991

Pharmacotherapy

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A variety of diseases are associated with elevation of pressure within the pulmonary circulation. Pulmonary hypertension is considered a contributor to the morbidity and mortality associated with these conditions. An understanding of the pathophysiology and consequences of pulmonary hypertension is required when considering pharmacologic treatment. Information regarding the potential benefits and toxicities of the drug therapy for primary and secondary hypertension is necessary when considering the use of specific agents for an individual patient.

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Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 94%

Pharmacologic Treatment of Primary and Secondary Pulmonary Hypertension

Brown

1991

Pharmacotherapy

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Prostaglandin deficiency

Moran¹,

Nicholson²

1990

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Healthy cells from virtually all tissues synthesize a variety of prostaglandins, autacoids which can significantly alter cellular functions. An absolute or relative deficiency of prostaglandins has now been demonstrated in many diseases or clinical conditions. These include 'natural' disorders such as peptic ulcer disease and diabetes mellitus. These also include 'acquired' or iatrogenic conditions such as cyclosporine nephrotoxicity and the gastropathy induced by nonsteroidal anti-inflammatory drugs. We believe that the diversity of the disorders associated with prostaglandin deficiency may be wider and of greater pathogenetic importance than is currently recognized. We propose: 1) that prostaglandin deficiency will be demonstrated in many abnormalities which are now described as of uncertain etiology; and 2) that adverse effects from many commonly prescribed drugs may also be related to an unrecognized and unfavorable alteration in prostaglandin synthesis, disposal, or activity.

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Prostaglandin E1 for patients who have both heart and lung failure after cardiotomy

Mayumi

Tokunaga

1993

The Journal of Thoracic and Cardiovascular Surgery

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Vasodilator therapy for right ventricular failure.

Cited by 8 publications

References 14 publications

Pharmacologic Treatment of Primary and Secondary Pulmonary Hypertension

Pharmacologic Treatment of Primary and Secondary Pulmonary Hypertension

Prostaglandin deficiency

Prostaglandin E1 for patients who have both heart and lung failure after cardiotomy

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