Vasodilatory Effect of Hydroxyethyl Methacrylate and Triethylene Glycol Dimethacrylate in Rat Aorta through Calcium Antagonistic Action

Guven, Gunseli; Seyrek, Melik; Vural, Ismail Mert; Çehrelį, Zafer C.; Yıldız, Oğuzhan

doi:10.1016/j.joen.2010.11.038

Cited by 6 publications

(1 citation statement)

References 18 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another set of experiments, to investigate the Ca 2+ -channel antagonistic of taurine, concentration-response curves to CaCl 2 (10 µM to 10 mM) were obtained in the absence and presence of taurine (20, 40, 80 mM) as described previously [ 11 18 19 ]. In this protocol, following the equilibration, RA rings were first challenged with 45 mM KCl to test tissue viability, and then the rings were washed three times at 15-min intervals with Ca 2+ -free Krebs solution containing 1 mM ethylenediaminetetraacetic acid (EDTA, disodium salt).…”

Section: Methodsmentioning

confidence: 99%

Taurine relaxes human radial artery through potassium channel opening action

Ulusoy

Kaya

Karabacak

et al. 2017

Korean J Physiol Pharmacol

Self Cite

View full text Add to dashboard Cite

The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM)-induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K+ channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 µM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride-induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine-induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl-induced contractions in RA, and suggest that large conductance Ca2+-activated K+ channels may be involved in taurine-induced relaxation of RA.

show abstract

Section: Methodsmentioning

confidence: 99%

Taurine relaxes human radial artery through potassium channel opening action

Ulusoy

Kaya

Karabacak

et al. 2017

Korean J Physiol Pharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

Propofol Relaxes Isolated Rat Aorta through BKCa Activation

Ulusoy

Doğan

Çam

et al. 2019

Annals of Vascular Surgery

View full text Add to dashboard Cite

Poly(propylene glycol) and urethane dimethacrylates improve conversion of dental composites and reveal complexity of cytocompatibility testing

et al. 2016

View full text Add to dashboard Cite

The use of UDMA and PPGDMA results in composites with excellent conversion, depth of cure and mechanical properties, without increasing shrinkage. Composites containing UDMA appear to be slightly more cytocompatible than those containing Bis-GMA. These monomers may therefore improve the material properties of dental restorations, particularly bulk fill materials. The effect of diluent monomer on cytocompatibility requires further investigation.

show abstract

Vasodilatory Effect of Hydroxyethyl Methacrylate and Triethylene Glycol Dimethacrylate in Rat Aorta through Calcium Antagonistic Action

Cited by 6 publications

References 18 publications

Taurine relaxes human radial artery through potassium channel opening action

Taurine relaxes human radial artery through potassium channel opening action

Propofol Relaxes Isolated Rat Aorta through BKCa Activation

Poly(propylene glycol) and urethane dimethacrylates improve conversion of dental composites and reveal complexity of cytocompatibility testing

Contact Info

Product

Resources

About