Vasomotion in Retinal Arterioles Is Modified by Exercise and Flicker Stimulation

Petersen, Line; Aalkjær, Christian; Bek, Toke

doi:10.1167/iovs.63.13.7

Cited by 3 publications

(1 citation statement)

References 33 publications

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“… 27 Such regional differences is supported by previous findings that spontaneous diameter oscillations and ischemic conditioning in the retina in healthy persons may differ among the peripheral and macular vessels. 28 – 30 The background for these differences, as well as the higher oxygen saturation in the macular than in the peripheral venules at rest 11 is unknown, but may be related to the shorter arterio-venous distance through the microcirculation in macular than in the peripheral circulation. 25 , 31 The observations are also in accordance with previous findings that diameter regulation is affected differently in arterioles supplying the retinal periphery and the macular area in patients with diabetic retinopathy, 32 but these studies were not supplemented with measurements of retinal blood flow.…”

Section: Discussionmentioning

confidence: 99%

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Drachmann,

Jeppesen,

Bek

2023

Invest. Ophthalmol. Vis. Sci.

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Purpose A recent study has shown that an increase in the arterial blood pressure of approximately 10 mm Hg in healthy persons can increase the oxygen saturation in venules from the retinal periphery but not from the macular area. The purpose of the present study was to investigate whether a higher increase in blood pressure has further effects on oxygen saturations and whether this is accompanied with changes in retinal blood flow. Methods In 30 healthy persons, oxygen saturation, diameter, and blood flow were measured in arterioles to and venules from the retinal periphery and the macular area. The experiments were performed before and during an experimental increase in arterial blood pressure of (mean ± SD) 18.3 ± 6.2 mm Hg. Results A higher number of venules than arterioles branching from the temporal vascular arcades to the macular area was balanced by a smaller diameter of the venules. Isometric exercise induced significant contraction of both peripheral and macular arterioles ( P < 0.01 for both comparisons) and significant increase in oxygen saturation in both peripheral and macular venules ( P < 0.001 for both comparisons). This was accompanied with a significant increase in the blood flow in the peripheral arterioles and venules ( P = 0.4 for both comparisons), but not in their macular counterparts ( P > 0.06 for both comparisons). Conclusions Increased systemic blood pressure leading to arterial contraction and increased venous oxygen saturation in the retina in normal persons can increase peripheral blood flow without significant effects on macular blood flow. This may contribute to explaining regional differences in the response pattern of retinal vascular disease.

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Section: Discussionmentioning

confidence: 99%

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Drachmann,

Jeppesen,

Bek

2023

Invest. Ophthalmol. Vis. Sci.

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Measuring flicker induced vasodilation at a high spatial and temporal resolution in the human retina

Senée,

Krafft,

Loukili

et al. 2024

Preprint

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Neurovascular coupling (NVC) is a crucial process in which blood flow is dynamically adjusted to meet the metabolic demands of active neurons. In this study, we introduce an innovative method for in-vivo imaging of retinal blood vessel dilation in response to visible light stimulation, offering insights into the functional regulation of retinal blood flow. Using high-resolution, high-speed phase contrast imaging, we continuously monitored retinal vessel dynamics in eight healthy subjects, capturing precise temporal and spatial changes in vessel size under both stimulated and baseline conditions. We have measured a significant vessel dilation of 5.2% +/- 1.6% (4.4 um +/- 1.3 um) during flicker-stimulation compared to a dilation of 2.5% +/- 1% (2.1 um +/- 0.9 um) without stimulation. The flexibility of our method also allowed for the exploration of various acquisition and stimulation settings, broadening possibilities for investigating neurovascular coupling in the retina. This work not only enhances our understanding of neurovascular coupling but also has the potential to identify new biomarkers for vision-impairing conditions and neurodegenerative diseases.

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Systemic Hypoxia and Interventions on Nitric Oxide Metabolism Affect Retinal Vasomotion in Healthy Subjects

Petersen,

Bek

2024

Invest. Ophthalmol. Vis. Sci.

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Vasomotion in Retinal Arterioles Is Modified by Exercise and Flicker Stimulation

Cited by 3 publications

References 33 publications

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Measuring flicker induced vasodilation at a high spatial and temporal resolution in the human retina

Systemic Hypoxia and Interventions on Nitric Oxide Metabolism Affect Retinal Vasomotion in Healthy Subjects

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