Vasomotor and depression symptoms may be associated with different sleep disturbance patterns in postmenopausal women

Vousoura, Eleni; Spyropoulou, Anastasia; Koundi, K.; Tzavara, Chara; Verdeli, Helen; Paparrigopoulos, Thomas; Augoulea, Areti; Lambrinoudaki, Ιrene; Zervas, Iannis M.

doi:10.1097/gme.0000000000000442

Cited by 33 publications

(32 citation statements)

References 31 publications

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“…Menopausal transition has been documented as an important hallmark for increased risk for sleep disturbances [5][6][7]. Furthermore, concurrent vasomotor symptoms add to the risk [9][10][11]24]. Thus, the existence of vasomotor symptoms might differentiate the distinct menopausal phenotypes, and hence identify those at risk for developing sleep disturbances.…”

Section: Discussionmentioning

confidence: 99%

Predictors of sleep disturbance in menopausal transition

et al. 2016

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a b s t r a c tObjective: This follow-up study aimed to evaluate risk factors for menopausal sleep disturbances already identifiable before menopause. Methods: At baseline, all 81 women were premenopausal. At year-five follow-up, 27 of the women were premenopausal, 40 postmenopausal, and 14 postmenopausal and using hormone therapy. We used the Basic Nordic Sleep Questionnaire to study sleep; additional questionnaires evaluated risk factors for sleep impairment.Results: Sleep quality differed only marginally between the groups. The following baseline variables were associated with impaired sleep quality at follow-up: depressive symptoms increased the risk of nocturnal awakenings (OR 1.16 (95%CI 1.02-1.32), p = 0.025), morning tiredness (OR 1.22 (95%CI 1.06-1.40), p = 0.007), daytime tiredness (OR 1.24 (95%CI 1.06-1.44), p = 0.007) and propensity to fall asleep during work or leisure time (OR 1.18 (95%CI 1.01-1.37), p = 0.036). Personal crises increased the risk of longer sleep latency (OR 5.46 (95%CI 1.13-26.32), p = 0.035) and of propensity to fall asleep when not active ), p = 0.014). Use of medications affecting the CNS increased the risk of worse general sleep quality (OR 11.44 (95% CI 1.07-121.79), p = 0.044). Perceived impaired general health (OR 2.87 (95%CI 1.04-7.94), p = 0.043) and frequent night sweats ), p = 0.003) increased the risk of difficulty falling asleep. Conclusions: Various premenopausal health-related factors seem to predict poor sleep in menopausal transition. Menopause itself appears to have only minor effects. Thus, it is essential to identify highrisk women to allow timely interventions that may prevent the development of sleep disturbances at menopause.

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Section: Discussionmentioning

confidence: 99%

Predictors of sleep disturbance in menopausal transition

et al. 2016

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“…10 Other causes may be psychological factors due to depression, emotional problems, or physical disturbances. [14][15][16][17][18][19] In fact, we observed a large number of patients with arthropathy that may limit their physical activity and worsen their quality of life. Moreover, our data showed that not all patients performed regular physical activity.…”

Section: Discussionmentioning

confidence: 99%

“…14 Regardless of the mechanism, we found a high number of patients with depression, which decreases the quality of life. [14][15][16][17][18] Fonseca et al 11 observed that $ 68% of the patients were overweight or obese during the climacterium. According to Lynch et al, 20 the excess weight may affect the overall health and the quality of life of women.…”

Section: Discussionmentioning

confidence: 99%

Brazilian Women's Health after 65 Years of Age

Fonseca

Bagnoli

Massabki

et al. 2017

Rev Bras Ginecol Obstet

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Keywords► aging ► menopause ► vasomotor symptoms ► body mass index ► sexual intercourse AbstractPurpose The aim of this study was to evaluate the health aspects of Brazilian women older than 65 years of age. Design This was a retrospective study that included 1,001 Brazilian women cared for in the gynecological geriatric outpatient office of our institution. We report a crosssectional analysis of female adults aged over 65 years, including data on demographics, clinical symptoms such as vasomotor symptoms, associated morbidities, physical examination and sexual intercourse. We used the chi-squared test to assess the data. Results The age of the patients on their first clinic visit ranged from 65 to 98 years, with a mean age of 68.56 AE 4.47 years; their mean age at the time of natural menopause was 48.76 AE 5.07 years. The most frequent clinical symptoms reported during the analyzed period were hot flashes (n ¼ 188), followed by arthropathy, asthenia, and dry vagina. The most frequent associated morbidities after 65 years of age were systemic arterial hypertension, gastrointestinal disturbance, diabetes mellitus, and depression, among others. The assessment of the body mass index (BMI) found decreases in BMI with increased age. At the time of the visit, 78 patients reported sexual intercourse. The majority of women reporting sexual intercourse (89.75%, n ¼ 70) were between 65 and 69 years of age, 8.97% (n ¼ 7) were between 70 and 74 years of age, and only 1.28% (n ¼ 1) of those were aged older than 75 years. Conclusions Our findings suggested that vasomotor symptoms can persist after 65 years of age. There was a significant decrease in sexual intercourse with increased age. The cardiovascular disturbances in our study are health concerns in these women. ResumoObjetivo Avaliar os aspectos de saúde das mulheres brasileiras após os 65 anos de idade. Métodos O estudo foi retrospectivo, e incluiu 1.001 mulheres brasileiras atendidas no ambulatório de ginecologia geriátrica de nossa instituição. Foi feita uma análise transversal de mulheres com idade acima de 65 anos, incluindo dados demográficos, sintomas clínicos (sintomas vasomotores), morbidades associadas, bem como

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“…The results of L. Kolesnikova et al (2017) have shown that perimenopausal women have more frequency of the difficulty falling asleep and postmenopausal ones have more the number of nocturnal awakenings [32]. Various works were devoted to the role of vasomotor symptoms in menopausal women in the pathogenesis of insomnia [24,46]. The presence of vasomotor symptoms in postmenopause makes the risk of night awakenings 1.85 times higher [46].…”

Section: Menopause As a Risk Factor Of Sleep Disordersmentioning

confidence: 99%

Insomnia and Circadian Rhythms of Melatonin in Menopausal Women

Semenova

Мадаева

Колесникова

2018

Acta biomedica scientifica

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The aim of the review is to analyze literature data about sleep homeostasis and the role of the one of circadian system key elements – melatonin – in the regulation of the sleep-wake cycle in women in menopause. It was shown that the prevalence and structure of sleep disorders depends on the menopausal phase. It was revealed that the melatonin content in the body, determined in various biological media (blood, saliva, urine), depends on age, sex, race, and chronotype. It was shown that morning melatonin can be used as a biological marker for determining the chronotype. Most studies indicated a decrease in melatonin level with aging. Moreover, women have lower melatonin level than men. In case of insomnia, lower melatonin level was found, although the results of the studies are ambiguous. The shift in the peak of hormone secretion in the early morning hours was described in menopausal women. Also, the dependence of melatonin circadian rhythm on the menopausal phase was revealed, which determines different approaches to insomnia therapy. We revealed the association of melatonin secretion circadian rhythms with Clock 3111T/C gene polymorphism in Caucasian patients with insomnia, which allows considering 3111T allele as risky in the formation of melatonin circadian rhythm disturbances in these patients.

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Vasomotor and depression symptoms may be associated with different sleep disturbance patterns in postmenopausal women

Cited by 33 publications

References 31 publications

Predictors of sleep disturbance in menopausal transition

Predictors of sleep disturbance in menopausal transition

Brazilian Women's Health after 65 Years of Age

Insomnia and Circadian Rhythms of Melatonin in Menopausal Women

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