Vasomotor dysfunction after cardiac surgery

Ruel, Marc; Khan, Tanveer A.; Voisine, Pierre; Bianchi, Cesario; Sellke, Frank W.

doi:10.1016/j.ejcts.2004.07.040

Cited by 89 publications

(120 citation statements)

References 145 publications

(180 reference statements)

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“…Dysfunction of the coronary microcirculation due to diabetes and CP/CPB may result in detrimental effects in myocardial perfusion and function. 2,18,20,21 In conclusion, CP/CPB was associated with alterations in myocardial expression and activation of MAPKs as well as vasomotor dysfunction of coronary arterioles in patients with CABG. Uncontrolled diabetes or diabetes combined with CP/ CPB further altered expression and activation of MAPKs, such as p38-MAPK, ERK1/2, JNK, and MKP-1.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12][13][14] Recent studies in our laboratory demonstrated that PKC-alpha and PKC-beta are upregulated and activated in the human diabetic (type 2) myocardium in the setting of CP/CPB. [15][16][17][18][19][20][21] Whether diabetes, particularly if combining with CP/CPB and cardiac surgery, further affects MAPKs signaling in the human myocardium has not been investigated.…”

mentioning

confidence: 99%

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Altered Expression and Activation of Mitogen-Activated Protein Kinases in Diabetic Heart During Cardioplegic Arrest and Cardiopulmonary Bypass

Feng

Liu

Dobrilovic

et al. 2013

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Altered Expression and Activation of Mitogen-Activated Protein Kinases in Diabetic Heart During Cardioplegic Arrest and Cardiopulmonary Bypass

Feng

Liu

Dobrilovic

et al. 2013

Journal of Surgical Research

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“…Surgical procedures such as cardiopulmonary bypass and organ transplantation provoke ischemia/reperfusion (IR) injury leading to an intense systemic inflammatory response and multiple organs failure that have been associated with high mortality rate [1][2][3]. The genesis of IR-induced deleterious effects has been linked to a massive reactive oxygen species (ROS) production by vascular endothelium and leukocytes [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Physical Training on the Cardio-Inflammatory Disorder Induced by Lung Ischemia/Reperfusion in Rats

et al. 2010

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Our laboratory demonstrated that training program attenuated the inflammatory responses in lung ischemia/reperfusion (IR). Considering the importance of the inflammatory responses on the cardiovascular system, we evaluate the effect of physical training on the vascular responsiveness and its underlying mechanism after lung IR. Male Wistar rats were submitted to run training and lung IR. Concentration-response curves for relaxing and contracting agents were obtained. Protein expressions of SOD-1 and p47(phox), plasma nitritre/nitrate (NO (x) (-) ) and interleukin 6 (IL-6) were evaluated. A decreased in the potency for acetylcholine and phenylephrine associated with an upregulation of the p47(phox) expression were found after Lung IR as well as an increase in IL-6 and NO (x) (-) levels. Run training attenuated the vascular dysfunction that was accompanied by reduction of the p47(phox) protein expression and IL-6 levels. Our findings show the beneficial effect of training on the vascular function that was associated with reduction in inflammatory response in lung IR.

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“…Interestingly, Ruel et al demonstrated that altered release of NO after cardiac surgery with CPB may lead to reduced peripheral and pulmonary resistance, and abnormal vascular permeability. Furthermore, these abnormalities may lead to organ dysfunction, such as organ edema, impaired regulation of myocardial perfusion and can contribute to myocardial and endothelial dysfunction [28]. Thus, this observed vasomotor dysfunction might be induced by the eNOS G894T polymorphism and/or CPB leading to an increased susceptibility to cleavage of the eNOS protein of the T genotypes.…”

Section: Discussionmentioning

confidence: 99%

The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery

Bireta¹,

Hinz²,

Lipke³

et al. 2014

Thorac cardiovasc Surg

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Background: The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB). In this study, we analyzed the influence of this gene polymorphism on early clinical outcome in patients who underwent cardiac surgery with CPB. Also, we performed a 5-year follow-up, assessing the impact of this polymorphism on long-term mortality. Method: 500 patients who underwent cardiac surgery with CPB between 2006 and 2007 were included in this prospective single centre study. Genotyping for the eNOS gene polymorphism was performed by polymerase chain reaction amplification. Results: Genotype distribution of 894G/T was: GG 50.2%; GT 42.2%; TT 7.8%. Cardiovascular risk factors were equally distributed between the different genotypes of the eNOS 894G/T polymorphism. No significant difference among the groups was shown regarding Euroscore, SAPS II and APACHE II. Perioperative characteristics were also not affected by the genotypes, except for the consumption of norepinephrine (p = 0.03) and amiodarone (p = 0.01) which was higher in the GT allele carrier. The early postoperative course was quite uniform across the genotypes, except for mean intensive care unit length of stay which was significantly prolonged in GT carriers (p = 0.001). The five-year follow-up was 100% complete and showed no significant differences regarding mortality between the groups.

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Vasomotor dysfunction after cardiac surgery

Cited by 89 publications

References 145 publications

Altered Expression and Activation of Mitogen-Activated Protein Kinases in Diabetic Heart During Cardioplegic Arrest and Cardiopulmonary Bypass

Altered Expression and Activation of Mitogen-Activated Protein Kinases in Diabetic Heart During Cardioplegic Arrest and Cardiopulmonary Bypass

Beneficial Effects of Physical Training on the Cardio-Inflammatory Disorder Induced by Lung Ischemia/Reperfusion in Rats

The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery

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