2008
DOI: 10.1016/j.fertnstert.2007.08.020
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Vasomotor symptoms in infertile premenopausal women: a hitherto unappreciated risk for low bone mineral density

Abstract: We demonstrate, in a premenopausal population of infertile women, evidence of morbid accompaniments to VMS, including sleep disturbances and evidence of low BMD. Our data further suggest a state of enhanced bone turnover in association with VMS, specifically in those experiencing NS. Declining ovarian reserve may be the common pathophysiological mechanism underlying VMS and low BMD in the symptomatic population and merits further investigation.

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Cited by 16 publications
(12 citation statements)
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“…Neither previous study compared the VMS-BMD association among women in different menopausal stages. Additional support for a VMS-BMD association in middle-aged women comes from a study of young infertile women showing that women with VMS had lower BMD and higher bone turnover than women without VMS 18.…”
Section: Discussionmentioning
confidence: 99%
“…Neither previous study compared the VMS-BMD association among women in different menopausal stages. Additional support for a VMS-BMD association in middle-aged women comes from a study of young infertile women showing that women with VMS had lower BMD and higher bone turnover than women without VMS 18.…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, patients with POF caused by chemotherapy present with rapid bone mineral loss (44). The cyclical relationship is exhibited in the exacerbation of vasomotor symptoms such as hot flashes and night sweats related to infertility by low BMD (45). Because estrogen helps protect against the destruction of osteoblasts, the decrease of estrogen due to infertility has potential to cause significant bone health issues for survivors.…”
Section: Physiological Effects Of Infertilitymentioning
confidence: 99%
“…Infertile women with vasomotor symptoms also had lower bone mineral density, after adjusting for age, body mass index (BMI), smoking and menstrual cycle regularity, and a higher prevalence of DOR. 113 The common denominator leading to vasomotor symptoms and bone loss is thought to be lower estradiol. However, increasing evidence suggests the elevated FSH with DOR, and/or the menopausal transition, may have a direct impact to increase osteoclastic bone resorption.…”
Section: Premenopausal Risk and Bone Lossmentioning
confidence: 99%