“…Given the high incidence of vasoplegic syndrome (up to 40%) and its association with decreased survival in multiple settings, including transplantation and cardiac surgery, there is active research into the pathophysiology of this syndrome. 23 The Clinical Challenges section of this issue presents 2 reports. The first one by Mocavero and colleagues, is a thought-provoking description of the management of a patient with severe functional mitral regurgitation with a MitraClip.…”