Vasopressin &amp; Oxytocin in Control of the Cardiovascular System: An Updated Review

Japundžić‐Žigon, Nina; Lozić, Maja; Šarenac, Olivera; Murphy, David

doi:10.2174/1570159x17666190717150501

Cited by 42 publications

(45 citation statements)

References 264 publications

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“…Going beyond individual genes, a ten-gene synteny window surrounding the vasotocin receptor 2C gene ( VTR2C ; also known as AVPR2 ), which is involved in blood pressure homeostasis and brain function 41 , 42 , was split into 34 contigs on four scaffolds, one of which contained a false haplotype duplication of ARHGAP4 in the previous platypus assembly 43 (Fig. 3i ).…”

Section: Improvements To Read Alignment and Annotationmentioning

confidence: 99%

Towards complete and error-free genome assemblies of all vertebrate species

Rhie

McCarthy

Fédrigo

et al. 2021

Nature

1,720

671

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High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are available for only a few non-microbial species1–4. To address this issue, the international Genome 10K (G10K) consortium5,6 has worked over a five-year period to evaluate and develop cost-effective methods for assembling highly accurate and nearly complete reference genomes. Here we present lessons learned from generating assemblies for 16 species that represent six major vertebrate lineages. We confirm that long-read sequencing technologies are essential for maximizing genome quality, and that unresolved complex repeats and haplotype heterozygosity are major sources of assembly error when not handled correctly. Our assemblies correct substantial errors, add missing sequence in some of the best historical reference genomes, and reveal biological discoveries. These include the identification of many false gene duplications, increases in gene sizes, chromosome rearrangements that are specific to lineages, a repeated independent chromosome breakpoint in bat genomes, and a canonical GC-rich pattern in protein-coding genes and their regulatory regions. Adopting these lessons, we have embarked on the Vertebrate Genomes Project (VGP), an international effort to generate high-quality, complete reference genomes for all of the roughly 70,000 extant vertebrate species and to help to enable a new era of discovery across the life sciences.

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Section: Improvements To Read Alignment and Annotationmentioning

confidence: 99%

Towards complete and error-free genome assemblies of all vertebrate species

Rhie

McCarthy

Fédrigo

et al. 2021

Nature

1,720

671

View full text Add to dashboard Cite

show abstract

“…Each of these genes is now present on one long contig, with no gaps and no false gene-region gains or losses in the VGP assemblies, validated in reliable blocks with support from two or more sequencing platforms ( Supplementary Table 21). Going beyond individual genes to gene synteny, a 10-gene window surrounding the vasotocin receptor 2C (VTR2C; aka AVPR2), a gene involved in blood pressure homeostasis and brain function 66,67 , was split into 34 contigs on four scaffolds, one containing a false haplotype duplication of ARHGAP4, in the prior Sanger-based platypus assembly (Fig. 5g).…”

Section: Improvements To Mapping and Annotationmentioning

confidence: 99%

Towards complete and error-free genome assemblies of all vertebrate species

Rhie

McCarthy

Fédrigo

et al. 2020

Preprint

250

464

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High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are only available for a few non-microbial species 1-4 . To address this issue, the international Genome 10K (G10K) consortium 5,6 has worked over a five-year period to evaluate and develop cost-effective methods for assembling the most accurate and complete reference genomes to date. Here we summarize these developments, introduce a set of quality standards, and present lessons learned from sequencing and assembling 16 species representing major vertebrate lineages (mammals, birds, reptiles, amphibians, teleost fishes and cartilaginous fishes). We confirm that long-read sequencing technologies are essential for maximizing genome quality and that unresolved complex repeats and haplotype heterozygosity are major sources of error in assemblies. Our new assemblies identify and correct substantial errors in some of the best historical reference genomes. Adopting these lessons, we have embarked on the Vertebrate Genomes Project (VGP), an effort to generate high-quality, complete reference genomes for all ~70,000 extant vertebrate species and help enable a new era of discovery across the life sciences.

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“…Oxytocin given in very high doses, change the mean level of arterial blood pressure in an opposing manner, however, under basal physiological conditions, oxytocin does not contribute to blood pressure maintenance [ 36 ]. The hypotensive action of oxytocin, demonstrated in animal models, is believed to be mediated by the direct effect on oxytocin receptors in the heart and the indirect effect of the release of atrial natriuretic peptide, brain natriuretic peptide, and nitric oxide in the cardiovascular tissues [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Dose of Oxytocin for Uterine Atony during Caesarean Delivery: A Systematic Review

Baliulienė

Vitartaitė

Rimaitis

2021

IJERPH

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Objective—to overview, compare and generalize results of randomized clinical trials analyzing different oxytocin doses to prevent postpartum hemorrhage, initiate and maintain uterine contraction after Caesarean delivery. Methods—‘PubMed’, ‘EMBASE’, ‘CENTRAL’, and ‘CINAHL’ electronic databases were searched for clinical trials analyzing the effectiveness of different dose of oxytocin given intravenously during surgery for uterine contraction and to reduce postpartum hemorrhage. A systematic review of relevant literature sources was performed. Results—our search revealed 813 literature sources. A total of 15 randomized clinical trials, comparing different doses of oxytocin bolus and infusion used after caesarean delivery have met the selection criteria. Conclusion—oxytocin bolus 0.5–3 UI is considered an effective prophylactic dose. Recommended effective prophylactic oxytocin infusion dose is 7.72 IU/h, but it is unanswered whether we really need a prophylactic infusion of oxytocin if we choose effective bolus dose size and rate. Adverse hemodynamic effects were observed when a 5 UI oxytocin bolus was used. However, topics such as bolus dose size, infusion dose size and requirement as well as bolus injection rate, still remain unanswered. The doses that are recommended in the guidelines of peripartum hemorrhage prophylaxis are not confirmed by randomized controlled double-blind trials and more research should cover this topic.

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Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review

Cited by 42 publications

References 264 publications

Towards complete and error-free genome assemblies of all vertebrate species

Towards complete and error-free genome assemblies of all vertebrate species

Towards complete and error-free genome assemblies of all vertebrate species

Prophylactic Dose of Oxytocin for Uterine Atony during Caesarean Delivery: A Systematic Review

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